Abstract
Molluscum contagiosum virus (MCV) is a poxvirus that causes localized papules in healthy persons. We evaluated a woman with severe immunodeficiency and disseminated MCV. During treatment with CMX-001, an antiviral with activity against other poxviruses, MCV DNA was detected in 20% of plasma samples. When the patient was not receiving CMX-001, MCV DNA was detected in 50% of samples. We also noted improvement in warts on her fingers during CMX-001 therapy. Although MCV is caused by direct inoculation of virus into skin in healthy persons, in a severely immunocompromised person MCV DNA was present in blood and may spread by viremia.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Adult
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Antiviral Agents / therapeutic use*
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Compassionate Use Trials
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Cytosine / analogs & derivatives*
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Cytosine / therapeutic use
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DNA, Viral / blood*
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Female
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Humans
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Immunologic Deficiency Syndromes / complications
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Molluscum Contagiosum / blood*
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Molluscum Contagiosum / complications
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Molluscum Contagiosum / drug therapy*
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Molluscum contagiosum virus*
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Organophosphonates / therapeutic use*
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Real-Time Polymerase Chain Reaction
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Young Adult
Substances
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Antiviral Agents
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DNA, Viral
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Organophosphonates
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brincidofovir
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Cytosine