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Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.
Kohchi Y, Hattori K, Oikawa N, Mizuguchi E, Isshiki Y, Aso K, Yoshinari K, Shirai H, Miwa M, Inagaki Y, Ura M, Ogawa K, Okabe H, Ishitsuka H, Shimma N. Kohchi Y, et al. Among authors: oikawa n. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2241-5. doi: 10.1016/j.bmcl.2007.01.066. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17306533
Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.
Hattori K, Kohchi Y, Oikawa N, Suda H, Ura M, Ishikawa T, Miwa M, Endoh M, Eda H, Tanimura H, Kawashima A, Horii I, Ishitsuka H, Shimma N. Hattori K, et al. Among authors: oikawa n. Bioorg Med Chem Lett. 2003 Mar 10;13(5):867-72. doi: 10.1016/s0960-894x(02)01082-x. Bioorg Med Chem Lett. 2003. PMID: 12617910
9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors.
Kinoshita K, Kobayashi T, Asoh K, Furuichi N, Ito T, Kawada H, Hara S, Ohwada J, Hattori K, Miyagi T, Hong WS, Park MJ, Takanashi K, Tsukaguchi T, Sakamoto H, Tsukuda T, Oikawa N. Kinoshita K, et al. Among authors: oikawa n. J Med Chem. 2011 Sep 22;54(18):6286-94. doi: 10.1021/jm200652u. Epub 2011 Aug 25. J Med Chem. 2011. PMID: 21823617
Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor.
Ito T, Kinoshita K, Tomizawa M, Shinohara S, Nishii H, Matsushita M, Hattori K, Kohchi Y, Kohchi M, Hayase T, Watanabe F, Hasegawa K, Tanaka H, Kuramoto S, Takanashi K, Oikawa N. Ito T, et al. Among authors: oikawa n. J Med Chem. 2022 Sep 22;65(18):12427-12444. doi: 10.1021/acs.jmedchem.2c01099. Epub 2022 Sep 6. J Med Chem. 2022. PMID: 36066182
Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors.
Kinoshita K, Ono Y, Emura T, Asoh K, Furuichi N, Ito T, Kawada H, Tanaka S, Morikami K, Tsukaguchi T, Sakamoto H, Tsukuda T, Oikawa N. Kinoshita K, et al. Among authors: oikawa n. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3788-93. doi: 10.1016/j.bmcl.2011.04.020. Epub 2011 Apr 22. Bioorg Med Chem Lett. 2011. PMID: 21561771
109 results