HGNC Approved Gene Symbol: KIF27
Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,834,099-83,921,432 (from NCBI)
By database searching using Drosophila Cos2 as probe, Katoh and Katoh (2004) identified KIF27. The deduced 1,401-amino acid protein contains N-terminal kinesin motor and Cubitus interruptus (see GLI3; 165240)-binding domains and a C-terminal Smoothened (SMOH; 601500)-binding domain, all in common with the Drosophila Cos2 domain structure. Katoh and Katoh (2004) reported that KIF27 shares 43.6% amino acid identity with KIF7 (611254) and 61.6% identity with KIF7 over the kinesin motor domain. KIF27 and KIF7 also share an additional region of high homology, which the authors called the KIF7-KIF27 homologous (KIF727H) domain. EST database analysis showed KIF27 mRNA expression in testis, pancreatic islet, germ cell tumors, and Jurkat T cells.
Sweetser et al. (2005) determined that the KIF27 gene contains 17 exons.
Wilson et al. (2009) demonstrated that mouse Fu (607652) is essential for construction of the central pair apparatus of motile, 9+2 cilia, and offers a new model of human primary ciliary dyskinesia (see 244400). They found that mouse Fu physically interacts with Kif27, a mammalian Cos2 ortholog, and linked Fu to known structural components of the central pair apparatus, providing evidence for the first regulatory component involved in central pair construction. Wilson et al. (2009) also demonstrated that zebrafish Fu is required both for hedgehog (see 600725) signaling and cilia biogenesis in Kupffer vesicle. Mouse Fu rescued both hedgehog-dependent and -independent defects in zebrafish. Wilson et al. (2009) concluded that their results delineated a new pathway for central pair apparatus assembly, identified common regulators of hedgehog signaling and motile ciliogenesis, and provided insights into the evolution of the hedgehog cascade.
By genomic sequence analysis, Katoh and Katoh (2004) mapped the KIF27 gene to chromosome 9q22.1. Sweetser et al. (2005) mapped the KIF27 gene to chromosome 9q21.32 by genomic sequence analysis.
Katoh, Y., Katoh, M. KIF27 is one of orthologs for Drosophila Costal-2. Int. J. Oncol. 25: 1875-1880, 2004. [PubMed: 15547729]
Katoh, Y., Katoh, M. Characterization of KIF7 gene in silico. Int. J. Oncol. 25: 1881-1886, 2004. [PubMed: 15547730]
Sweetser, D. A., Peniket, A. J., Haaland, C., Blomberg, A. A., Zhang, Y., Zaidi, S. T., Dayyani, F., Zhao, Z., Heerema, N. A., Boultwood, J., Dewald, G. W., Paietta, E., Slovak, M. L., Willman, C. L., Wainscoat, J. S., Bernstein, I. D., Daly, S. B. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. Genes Chromosomes Cancer 44: 279-291, 2005. [PubMed: 16015647] [Full Text: https://doi.org/10.1002/gcc.20236]
Wilson, C. W., Nguyen, C. T., Chen, M.-H., Yang, J.-H., Gacayan, R., Huang, J., Chen, J.-N., Chuang, P.-T. Fused has evolved divergent roles in vertebrate hedgehog signalling and motile ciliogenesis. Nature 459: 98-102, 2009. [PubMed: 19305393] [Full Text: https://doi.org/10.1038/nature07883]