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Temporal-Specific Sex and Injury-Dependent Changes on Neurogranin-Associated Synaptic Signaling After Controlled Cortical Impact in Rats
Extensive effort has been made to study the role of synaptic deficits in cognitive impairment after traumatic brain injury (TBI). Neurogranin (Ng) is...
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The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders
Individuals with neurodevelopmental disorders experience persistent sleep deficits, and there is increasing evidence that sleep dysregulation is an...
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Small, correlated changes in synaptic connectivity may facilitate rapid motor learning
Animals rapidly adapt their movements to external perturbations, a process paralleled by changes in neural activity in the motor cortex. Experimental...
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Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease
The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography (PET) and plasma analysis in...
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Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
Over the last five decades, a large body of evidence has accrued for structural and metabolic brain alterations in schizophrenia. Here we provide an...
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Intra-hippocampal cis-P tau microinjection induces long-term changes in behavior and synaptic plasticity in mice
BackgroundAlzheimer's disease is accompanied by an abnormal high accumulation of cis-P tau. However, the long-term changes in behavior following tau...
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Changes in cognitive function, synaptic structure and protein expression after long-term exposure to 2.856 and 9.375 GHz microwaves
Health hazards from long-term exposure to microwaves, especially the potential for changes in cognitive function, are attracting increasing...
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Synaptic Scaling and Homeostasis
Synaptic scaling is a hypothesis that is accepted by many neuroscientists. Its main premise is that both excitatory and inhibitory synaptic weights... -
Synaptic and mitochondrial mechanisms behind alcohol-induced imbalance of excitatory/inhibitory synaptic activity and associated cognitive and behavioral abnormalities
Alcohol consumption during pregnancy can significantly impact the brain development of the fetus, leading to long-term cognitive and behavioral...
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Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles
Neuronal communication relies on the release of neurotransmitters from various populations of synaptic vesicles. Despite displaying vastly different...
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Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density
ObjectiveDespite being one of the most prevalent neurological diseases, the pathophysiology of essential tremor (ET) is not fully understood....
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Synaptic Tagging and Metaplasticity as Mediators of Neuronal Consciousness
Forming memories for highly arousing, novel, or salient events engages synaptic mechanisms that allow the association of temporally remote events and... -
Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes
Muskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane receptor trafficking. However, its influence on intrinsic brain...
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Synaptic ribbon dynamics after noise exposure in the hearing cochlea
Moderate noise exposure induces cochlear synaptopathy, the loss of afferent ribbon synapses between cochlear hair cells and spiral ganglion neurons,...
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New perspective on sustained antidepressant effect: focus on neurexins regulating synaptic plasticity
Depression is highly prevalent globally, however, currently available medications face challenges such as low response rates and short duration of...
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Lifelong changes of neurotransmitter receptor expression and debilitation of hippocampal synaptic plasticity following early postnatal blindness
In the weeks immediately after onset of sensory loss, extensive reorganization of both the cortex and hippocampus occurs. Two fundamental...
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Compartmentalization of Synaptic Tagging and Capture
Testing of the synaptic tagging and capture (STC) hypothesis has produced remarkable work on the understanding of how a single neuron undergoes... -
Synaptic PET Imaging in Neurodegeneration
Synaptic vesicle glycoprotein 2A (SV2A) is an integral glycoprotein in synaptic vesicle membranes and has been investigated as a potential positron... -
Activity-Dependent Protein Transport as a Synaptic Tag
The “synaptic tagging and capture” hypothesis proposes that a hypothetical, cell biological mark is activated in the synapses undergoing early-phase... -
LTP Revisited: Reconsidering the Explanatory Power of Synaptic Efficacy
Changes in synaptic strength are described as a unifying hypothesis for memory formation and storage, leading philosophers to consider the ‘synaptic...