Search
Search Results
-
Differentiating Prodromal Dementia with Lewy Bodies from Prodromal Alzheimer’s Disease: A Pragmatic Review for Clinicians
This pragmatic review synthesises the current understanding of prodromal dementia with Lewy bodies (pDLB) and prodromal Alzheimer’s disease (pAD),...
-
Diagnostic accuracy of research criteria for prodromal frontotemporal dementia
BackgroundThe Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia...
-
A look back at the prodromal findings in Parkinson’s disease
BackgroundParkinson's disorder is a neurodegenerative illness that displays motor and non-motor manifestations. There is no definite cause of...
-
Exploration of neuroanatomical characteristics to differentiate prodromal Alzheimer’s disease from cognitively unimpaired amyloid-positive individuals
Differentiating clinical stages based solely on positive findings from amyloid PET is challenging. We aimed to investigate the neuroanatomical...
-
Symptoms and age of prodromal Alzheimer’s disease in Down syndrome: a systematic review and meta-analysis
The diagnostic criteria for adult-onset Alzheimer’s disease (AD) in patients with Down syndrome (DS) have not been standardised. This study...
-
From the prodromal stage of multiple sclerosis to disease prevention
A prodrome is an early set of signs or symptoms that indicate the onset of a disease before more typical symptoms develop. Prodromal stages are well...
-
Prodromal multiple sclerosis: considerations and future utility
A multiple sclerosis (MS) prodrome has recently been described and is characterised by increased rates of healthcare utilisation and an excess...
-
Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia
BackgroundIn Hereditary Spastic Paraplegia (HSP) type 4 (SPG4) a length-dependent axonal degeneration in the cortico-spinal tract leads to...
-
Externally validated deep learning model to identify prodromal Parkinson’s disease from electrocardiogram
Little is known about electrocardiogram (ECG) markers of Parkinson’s disease (PD) during the prodromal stage. The aim of the study was to build a...
-
The clinical phenotype of psychiatric-onset prodromal dementia with Lewy bodies: a scoping review
BackgroundRecent consensus research criteria have identified a ‘psychiatric onset’ form of prodromal dementia with Lewy bodies (DLB) characterised by...
-
Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?
To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD...
-
Atypical prediction error learning is associated with prodromal symptoms in individuals at clinical high risk for psychosis
Reductions in the auditory mismatch negativity (MMN) have been well-demonstrated in schizophrenia rendering it a promising biomarker for...
-
Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort
BackgroundIsolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies...
-
Is later-life depression a risk factor for Alzheimer’s disease or a prodromal symptom: a study using post-mortem human brain tissue?
BackgroundDepression and dementia are both common diseases. Although new cases of depression are more common in younger adults, there is a second...
-
Gender disparities in the mediating role of symptom knowledge level in reducing acute coronary syndrome (ACS) decision delay: Findings from a community-based study in China
BackgroundImplementing training programs to educate patients on the prodromal symptoms of acute coronary syndrome (ACS) may assist patients in...
-
Prodromal Parkinson's disease: hype or hope for disease-modification trials?
The ultimate goal in Parkinson's disease (PD) research remains the identification of treatments that are capable of slowing or even halting the...
-
Prodromal frontotemporal dementia: clinical features and predictors of progression
BackgroundThe prodromal phase of frontotemporal dementia (FTD) is still not well characterized, and conversion rates to dementia and predictors of...
-
Oculomotor abnormalities indicate early executive dysfunction in prodromal X-linked dystonia-parkinsonism (XDP)
BackgroundX-Linked dystonia-parkinsonism (XDP) is a movement disorder characterized by the presence of both dystonia and parkinsonism with one or the...
-
Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson’s disease
Trehalose has been recently revealed as an attractive candidate to prevent and modify Parkinson’s disease (PD) progression by regulating autophagy;...