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Overcoming Bacteriophage Resistance in Phage Therapy
Antibiotic resistance among pathogenic bacteria is one of the most severe global challenges. It is predicted that over ten million lives will be lost... -
Phage predation accelerates the spread of plasmid-encoded antibiotic resistance
Phage predation is generally assumed to reduce microbial proliferation while not contributing to the spread of antibiotic resistance. However, this...
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Bacteriophage genome engineering for phage therapy to combat bacterial antimicrobial resistance as an alternative to antibiotics
Bacteriophages (phages) are viruses that mainly infect bacteria and are ubiquitously distributed in nature, especially to their host. Phage...
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Phage Transduction of Staphylococcus aureus
Bacteriophage transduction is the major mechanism of horizontal gene transfer (HGT) among many bacteria. In Staphylococcus aureus, the phage-mediated... -
Structures and activation mechanism of the Gabija anti-phage system
Prokaryotes have evolved intricate innate immune systems against phage infection
1 –7 . Gabija is a highly widespread prokaryotic defence system that... -
Salmonella enteritidis acquires phage resistance through a point mutation in rfbD but loses some of its environmental adaptability
Phage therapy holds promise as an alternative to antibiotics for combating multidrug-resistant bacteria. However, host bacteria can quickly produce...
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The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibiotics
Toxic bacterial modules such as toxin–antitoxin systems hold antimicrobial potential, though successful applications are rare. Here we show that in Vib...
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Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion
Defence-associated sirtuins (DSRs) comprise a family of proteins that defend bacteria from phage infection via an unknown mechanism. These proteins...
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Structural and functional characterization of cyclic pyrimidine-regulated anti-phage system
3’,5’-cyclic uridine monophosphate (cUMP) and 3’,5’-cyclic cytidine monophosphate (cCMP) have been established as bacterial second messengers in the...
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Dominance of phage particles carrying antibiotic resistance genes in the viromes of retail food sources
The growth of antibiotic resistance has stimulated interest in understanding the mechanisms by which antibiotic resistance genes (ARG) are mobilized....
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Characterization and genome-informatic analysis of a novel lytic Pseudomonas mendocina phage vB_PmeS_STP12 suitable for phage therapy or biocontrol
BackgroundA novel lytic bacteriophage (phage) was isolated with Pseudomonas mendocina strain STP12 ( P. mendocina ) from the untreated site of Sewage...
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Capsules and their traits shape phage susceptibility and plasmid conjugation efficiency
Bacterial evolution is affected by mobile genetic elements like phages and conjugative plasmids, offering new adaptive traits while incurring fitness...
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Structural basis of Gabija anti-phage defence and viral immune evasion
Bacteria encode hundreds of diverse defence systems that protect them from viral infection and inhibit phage propagation
1 –5 . Gabija is one of the... -
Antibacterial effects of single phage and phage cocktail against multidrug-resistant Klebsiella pneumoniae isolated from diabetic foot ulcer
Diabetic foot ulcer (DFU) is associated with long-term hospitalization and amputation. Antibiotic resistance has made the infection eradication more...
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Phage Therapy for Respiratory Infections: Opportunities and Challenges
We are entering the post-antibiotic era. Antimicrobial resistance (AMR) is a critical problem in chronic lung infections resulting in progressive...
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Two novel phages, Klebsiella phage GADU21 and Escherichia phage GADU22, from the urine samples of patients with urinary tract infection
Phages are found in a wide variety of places where bacteria exist including body fluids. The aim of the present study was to isolate phages from the...
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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance
Acquired resistance to cetuximab in colorectal cancers is partially mediated by the acquisition of mutations located in the cetuximab epitope in the...
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Genome-driven elucidation of phage-host interplay and impact of phage resistance evolution on bacterial fitness
When considering the interactions between bacteriophages and their host, the issue of phage-resistance emergence is a key element in understanding...
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Antagonistic interactions between phage and host factors control arbitrium lysis–lysogeny decision
Phages can use a small-molecule communication arbitrium system to coordinate lysis–lysogeny decisions, but the underlying mechanism remains unknown....
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Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo
Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease including sepsis. Carbapenem-resistant P. aeruginosa is recognised...