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Overcoming Bacteriophage Resistance in Phage Therapy
Antibiotic resistance among pathogenic bacteria is one of the most severe global challenges. It is predicted that over ten million lives will be lost... -
Phage-layer interferometry: a companion diagnostic for phage therapy and a bacterial testing platform
The continuing and rapid emergence of antibiotic resistance (AMR) calls for innovations in antimicrobial therapies. A promising, ‘re-emerging’...
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A Review of Phage Therapy for Bone and Joint Infections
There is a strong rationale for using phages in patients with bone and joint infections (BJIs). Indeed, specific phages can infect and replicate in... -
Phage Therapy for Respiratory Infections: Opportunities and Challenges
We are entering the post-antibiotic era. Antimicrobial resistance (AMR) is a critical problem in chronic lung infections resulting in progressive...
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Propagation, Purification, and Characterization of Bacteriophages for Phage Therapy
Phage therapy is an alternative approach to combat bacterial infections. In this approach, bacteriophages are used as antimicrobial agents due to... -
Oral phage therapy with microencapsulated phage A221 against Escherichia coli infections in weaned piglets
BackgroundEscherichia coli (E. coli) is a common pathogen that often causes diarrhea in piglets. Since bacteria are becoming more and more resistant...
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Characterization and genome-informatic analysis of a novel lytic Pseudomonas mendocina phage vB_PmeS_STP12 suitable for phage therapy or biocontrol
BackgroundA novel lytic bacteriophage (phage) was isolated with Pseudomonas mendocina strain STP12 ( P. mendocina ) from the untreated site of Sewage...
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Perspectives on phage therapy for health management in aquaculture
Though biosecurity and best management practices (BMPs), vaccines, immunostimulants, probiotics and prebiotics are often used for health management...
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Phage Display as a Medium for Target Therapy Based Drug Discovery, Review and Update
Phage libraries are now amongst the most prominent approaches for the identification of high-affinity antibodies/peptides from billions of displayed...
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Bacteriophage DNA induces an interrupted immune response during phage therapy in a chicken model
One of the hopes for overcoming the antibiotic resistance crisis is the use of bacteriophages to combat bacterial infections, the so-called phage...
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Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University
Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the...
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Bacteriophage genome engineering for phage therapy to combat bacterial antimicrobial resistance as an alternative to antibiotics
Bacteriophages (phages) are viruses that mainly infect bacteria and are ubiquitously distributed in nature, especially to their host. Phage...
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Controlling the bacterial load of Salmonella Typhi in an experimental mouse model by a lytic Salmonella phage STWB21: a phage therapy approach
BackgroundSalmonella enterica serotype Typhi is one of the major pathogens causing typhoid fever and a public health burden worldwide. Recently, the...
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Bacteriophage protein Dap1 regulates evasion of antiphage immunity and Pseudomonas aeruginosa virulence impacting phage therapy in mice
Bacteriophages have evolved diverse strategies to overcome host defence mechanisms and to redirect host metabolism to ensure successful propagation....
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Phage therapy as a glimmer of hope in the fight against the recurrence or emergence of surgical site bacterial infections
PurposeOver the last decade, surgery rates have risen alarmingly, and surgical-site infections are expanding these concerns. In spite of advances in...
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Phage Therapy for Nontuberculous Mycobacteria: Challenges and Opportunities
Non-tuberculous mycobacterium (NTM) infections are often clinically challenging, with lengthy antibiotic regimens that fail to resolve the infections...
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Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions
Acne vulgaris is a common neutrophil-driven inflammatory skin disorder in which Cutibacterium acnes ( C. acnes ) is known to play a key role. For...
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Phage Therapy: Genomics to Applications and Future Prospects
Bacteriophages are unique organisms with diverse genomic orientation and enriched with beneficial characteristics. Phage therapy was initially...