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Membrane transformations of fusion and budding
Membrane fusion and budding mediate fundamental processes like intracellular trafficking, exocytosis, and endocytosis. Fusion is thought to open a...
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Mechanisms of SNARE proteins in membrane fusion
Soluble N -ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic proteins that mediate...
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Navigating the mechanistic pathways of membrane fusion: the lipid perspective
Membrane fusion is an essential process for the survival of eukaryotes and entry of the enveloped viruses. Fusion machines (proteins) and membrane...
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Control of artificial membrane fusion in physiological ionic solutions beyond the limits of electroformation
Membrane fusion, merging two lipid bilayers, is crucial for fabricating artificial membrane structures. Over the past 40 years, in contrast to...
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The Art of Viral Membrane Fusion and Penetration
As obligate pathogens, viruses have developed diverse mechanisms to deliver their genome across host cell membranes to sites of virus replication.... -
A supramolecular system mimicking the infection process of an enveloped virus through membrane fusion
Membrane fusion is an essential step for the entry of enveloped viruses, such as human immunodeficiency virus and influenza virus, into the host...
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Lipid and Lipidation in Membrane Fusion
Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion...
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Dissecting the mechanism of atlastin-mediated homotypic membrane fusion at the single-molecule level
Homotypic membrane fusion of the endoplasmic reticulum (ER) is mediated by dynamin-like GTPase atlastin (ATL). This fundamental process relies on...
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Identification of small molecules capable of enhancing viral membrane fusion
Several approaches have been developed to analyze the entry of highly pathogenic viruses. In this study, we report the implementation of a...
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C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy
The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in...
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StayGold variants for molecular fusion and membrane-targeting applications
Although StayGold is a bright and highly photostable fluorescent protein, its propensity for obligate dimer formation may hinder applications in...
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Relevance of the Entry by Fusion at the Cytoplasmic Membrane vs. Fusion After Endocytosis in the HIV and SARS-Cov-2 Infections
HIV-1 and SARS-Cov-2 fuse at the cell surface or at endosomal compartments for entry into target cells; entry at the cell surface associates to... -
Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration
Synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that regulate exocytosis in neuronal and neuroendocrine cells. Upon binding...
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Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery
Chikungunya virus (CHIKV) is a human pathogen that delivers its genome to the host cell cytoplasm through endocytic low pH-activated membrane fusion...
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Membrane fusion, potential threats, and natural antiviral drugs of pseudorabies virus
Pseudorabies virus (PrV) can infect several animals and causes severe economic losses in the swine industry. Recently, human encephalitis or...
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Mechanism of Membrane Fusion: Interplay of Lipid and Peptide
Membrane fusion is an essential process for the survival of eukaryotes and the entry of enveloped viruses into host cells. A proper understanding of...
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Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion
BackgroundViral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing...
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Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration
To infect, enveloped viruses employ spike protein, spearheaded by its amphipathic fusion peptide (FP), that upon activation extends out from the...
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Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci
Casparian strips (CS) are aligned bands of lignin-impregnated cell walls, building an extracellular diffusion barrier in roots. Their structure...
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Membrane attachment and fusion of HIV-1, influenza A, and SARS-CoV-2: resolving the mechanisms with biophysical methods
Attachment to and fusion with cell membranes are two major steps in the replication cycle of many human viruses. We focus on these steps for three...