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Pervasive environmental chemicals impair oligodendrocyte development
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as their development extends...
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Stalled oligodendrocyte differentiation in IDH-mutant gliomas
BackgroundRoughly 50% of adult gliomas harbor isocitrate dehydrogenase ( IDH ) mutations. According to the 2021 WHO classification guideline, these...
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Deciphering Oligodendrocyte Lineages in the Human Fetal Central Nervous System Using Single-Cell RNA Sequencing
Oligodendrocytes form myelin sheaths and wrap axons of neurons to facilitate various crucial neurological functions. Oligodendrocyte progenitor cells...
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Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection
Zika virus (ZikV) infection during pregnancy can cause congenital Zika syndrome (CZS) and neurodevelopmental delay in infants, of which the...
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ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function
Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome (ANDS), a rare genetic disease characterized by autism spectrum...
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Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension
Myelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS....
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The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells
The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes to efflux unesterified cholesterol, and its deficiency...
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Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration
Failed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in...
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TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids
Three Prime Repair Exonuclease 1 ( TREX1 ) gene mutations have been associated with Aicardi-Goutières Syndrome (AGS) – a rare, severe pediatric...
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Isolation and Culture of Mouse Primary Microglia and Oligodendrocyte Precursor Cells
Microglia and oligodendrocyte precursor cells (OPCs) are critical glia subsets in the central nervous system (CNS) and are actively engaged in a body... -
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
BackgroundOligodendrocytes have robust regenerative ability and are key players in remyelination during physiological and pathophysiological states....
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Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation
Myelination is a process tightly regulated by a variety of neurotrophic factors. Here, we show—by analyzing two transgenic mouse lines, one...
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Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum
Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic and GABAergic axons and can be dynamically regulated by...
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Myelination-independent functions of oligodendrocyte precursor cells in health and disease
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found throughout the CNS, constituting approximately 5% of all...
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Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice
Myelin degeneration occurs in neurodegenerative diseases and aging. In these conditions, resident oligodendrocyte progenitor cells (OPCs)...
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Recombinant Erythropoietin Induces Oligodendrocyte Progenitor Cell Proliferation After Traumatic Brain Injury and Delayed Hypoxemia
Traumatic brain injury (TBI) can result in axonal loss and demyelination, leading to persistent damage in the white matter. Demyelinated axons are...
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Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon
BackgroundE-proteins encoded by Tcf3 , Tcf4 , and Tcf12 are class I basic helix-loop-helix (bHLH) transcription factors (TFs) that are thought to be...
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In Vivo Viral Gene Delivery to Manipulate Functional Properties of AMPA Receptors in Oligodendrocyte Lineage Cells
Delivery or deletion of genes of interest in the nervous system of animals in vivo is a complex and difficult task. While genetic manipulations can... -
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the...
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Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination
The metabolic needs of the premature/premyelinating oligodendrocytes (pre-OLs) and mature oligodendrocytes (OLs) are distinct. The metabolic control...