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A prognostic neural epigenetic signature in high-grade glioma
Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited. We present an epigenetically...
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Serum lipids concentration on prognosis of high-grade glioma
ObjectiveTo investigate the effect of serum lipids concentration on the prognosis of high-grade glioma patients undergoing postoperative radiotherapy.
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Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma
Recurrent, clonal somatic mutations in histone H3 are molecular hallmarks that distinguish the genetic mechanisms underlying pediatric and adult...
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Efficacy and indications of gamma knife radiosurgery for recurrent low-and high-grade glioma
PurposeTo investigate the indications and efficacy of gamma knife radiosurgery (GKRS) as a salvage treatment for recurrent low-and high-grade glioma.
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Radiomic white matter parameters of functional integrity of the corticospinal tract in high-grade glioma
Tractography has become a widely available tool for the planning of neurosurgical operations as well as for neuroscientific research. The absence of...
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Three-Dimensional Representation and Visualization of High-Grade and Low-Grade Glioma by Nakagami Imaging
Three-dimensional (3D) visualization of the brain tumors reconstructed from the two-dimensional (2D) magnetic resonance imaging (MRI) sequences plays... -
High-grade glioma in infants and very young children: characteristics, treatment, and outcomes
PurposeHigh-grade gliomas in infants and very young children (less than 3 to 5 years old) pose significant challenges due to the limited scientific...
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Clinical and molecular determinants of bleeding-related adverse outcomes in high-grade glioma
PurposeCancer is an independent risk factor for the development of venous thromboembolism (VTE). However, patients with high-grade glioma (HGG)...
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Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients
PurposeThe changes in serum amino acid profiles are evaluated in different types of cancers and screening tests were developed for estimating the...
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Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor...
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Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial
Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that...
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Evaluation of chemotherapy-induced nausea and vomiting in pediatric patients with high-grade glioma treated with lomustine—a case series
PurposeAlthough lomustine has been used as a chemotherapeutic agent for decades, no recommendation on appropriate chemotherapy-induced nausea and...
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Palliative care referral across the disease trajectory in high-grade glioma
PurposeAdults with high-grade glioma (HGG), WHO grade III or IV, have substantial palliative care needs. Our aim was to determine occurrence, timing,...
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Significance of O6-methyl guanine methyltransferase promoter methylation in high grade glioma patients: optimal cutoff point, CpG locus, and genetic assay
PurposeTo evaluate O6-methyl guanine methyltransferase ( MGMT ) promoter methylation status in high grade glioma patients and to identify the best...
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First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound
Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with microbubbles to enrich circulating brain disease-specific biomarkers...
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Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor characterized by a specific DNA...
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Protoporphyrin IX in serum of high-grade glioma patients: A novel target for disease monitoring via liquid biopsy
High-grade gliomas (HGG) carry a dismal prognosis. Diagnosis comprises MRI followed by histopathological evaluation of tissue; no blood biomarker is...
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High-Grade Gliomas
Up to 85% of all newly diagnosed instances of malignant primary brain tumors are high-grade gliomas (adult-type diffuse WHO grade 3 and 4 gliomas),... -
Application of PET imaging delta radiomics for predicting progression-free survival in rare high-grade glioma
This study assesses the feasibility of using a sample-efficient model to investigate radiomics changes over time for predicting progression-free...
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Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis
PurposeResection of high-grade gliomas has been considerably improved by 5-aminolevulinic acid (5-ALA). However, not all neurobiological properties...