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How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble...
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Histogenesis of intracranial germ cell tumors: primordial germ cell vs. embryonic stem cell
IntroductionIntracranial germ cell tumor (iGCT) is a rare disorder and often occurs during childhood and adolescence. iGCTs are frequently localized...
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Male germ cell proliferation and apoptosis in sexually immature meagre Argyrosomus regius (Asso, 1801) treated with recombinant follicle stimulating hormone
The meagre Argyrosomus regius (Asso, 1801) is a marine fish species that has an increasing aquaculture production in Europe. Lowering the age at...
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The matrisome landscape controlling in vivo germ cell fates
The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers...
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Is losartan a promising agent for the treatment of type 1 diabetes-induced testicular germ cell apoptosis in rats?
BackgroundDiabetes mellitus (DM) is common metabolic disease that poses a major risk to public health and fertility. Previous studies indicate that...
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Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy
Inheritance of stable and euploid genomes is a prerequisite for species maintenance. The DNA damage response in germ cells controls the integrity of...
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Cell Cycle Regulation in Mammalian Germ Cells
Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of... -
Primordial germ cell DNA demethylation and development require DNA translesion synthesis
Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. The DDR is required...
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Overexpression of SerpinB9 in non-seminomatous germ cell tumors
Serpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis...
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Long-term consumption of fermented pork fat-based diets differing in calorie, fat content, and fatty acid levels mediates oxidative stress, inflammation, redox imbalance, germ cell apoptosis, disruption of steroidogenesis, and testicular dysfunction in Wistar rats
There is a dearth of experimental evidence available as to whether the consumption of fermented pork fat (FPF) food has any harmful effects on...
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Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rats: a comparative study
BackgroundTesticular torsion is a pathological condition which needs emergency surgical intervention. However, after surgical reperfusion, oxidative...
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The neonatal southern white rhinoceros ovary contains oogonia in germ cell nests
The northern white rhinoceros is functionally extinct with only two females left. Establishing methods to culture ovarian tissues, follicles, and...
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CDKN2AIP is critical for spermiogenesis and germ cell development
BackgroundAs a member of RNA-binding protein, CDKN2AIP has been shown to play a critical role in stem cell pluripotency and somatic differentiation....
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Epigenetic markers in the embryonal germ cell development and spermatogenesis
Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis....
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Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours
BackgroundType II testicular germ cell tumours (TGCT) are the most prevalent tumours in young men. Patients suffering from cisplatin-resistant TGCTs...
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Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade
Epithelial ovarian cancer (EOC) is one of the most common malignant gynecological tumors with rapid growth potential and poor prognosis, however, the...
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Defb19 regulates the migration of germ cell and is involved in male fertility
β-defensins are small antimicrobial peptides that play essential roles in male fertility. Although several members of the β-defensin family are...
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Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms
Bisphenol A (BPA) is a commonly used environmental toxicant, is easily exposed to the human body and causes testicular damage, sperm abnormalities,...
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Higher-order epistasis shapes natural variation in germ stem cell niche activity
To study how natural allelic variation explains quantitative developmental system variation, we characterized natural differences in germ stem cell...
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MAX controls meiotic entry in sexually undifferentiated germ cells
Meiosis is a specialized type of cell division that occurs physiologically only in germ cells. We previously demonstrated that MYC-associated factor...