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A typical human red blood cell has a disk diameter of approximately [[1 E-6 m|6.2–8.2 µm]]<ref>{{cite book|title=Clinical Hematology: Theory and Procedures|author=Mary Louise Turgeon|publisher=Lippincott Williams & Wilkins|year=2004|page=100|url=https://books.google.com/books?id=cHAjsUgegpQC&q=erythrocyte%20size&pg=PA100|isbn=9780781750073}}</ref> and a thickness at the thickest point of 2–2.5&nbsp;µm and a minimum thickness in the centre of 0.8–1&nbsp;µm, being much smaller than most other [[List of distinct cell types in the adult human body|human cells]]. These cells have an average volume of about [[Femto-|90 fL]]<ref>{{cite journal | pmid = 3565597 | volume=252 | issue=4 Pt 2 | title=Statistical and graphical evaluation of erythrocyte volume distributions |date=April 1987 | journal=Am. J. Physiol. | pages=H857–66 | authors=McLaren CE, Brittenham GM, Hasselblad V| doi=10.1152/ajpheart.1987.252.4.H857 | citeseerx=10.1.1.1000.348 }}</ref> with a surface area of about 136 μm<sup>2</sup>, and can swell up to a sphere shape containing 150 fL, without membrane distension.
 
Adult humans have roughly 20–30&nbsp;trillion red blood cells at any given time, constituting approximately 70% of all cells by number.<ref>{{Cite journal|last1=Bianconi|first1=Eva|last2=Piovesan|first2=Allison|last3=Facchin|first3=Federica|last4=Beraudi|first4=Alina|last5=Casadei|first5=Raffaella|last6=Frabetti|first6=Flavia|last7=Vitale|first7=Lorenza|last8=Pelleri|first8=Maria Chiara|last9=Tassani|first9=Simone|date=1 November 2013|title=An estimation of the number of cells in the human body|journal=Annals of Human Biology|volume=40|issue=6|pages=463–71|doi=10.3109/03014460.2013.807878|pmid=23829164|hdl=11585/152451 |s2cid=16247166|issn=0301-4460}}</ref> Women have about 4–5&nbsp;million red blood cells per microliter (cubic millimeter) of blood and men about 5–6&nbsp;million; [[Effects of high altitude on humans#Acclimatization to altitude|people living at high altitudes]] with low oxygen tension will have more. Red blood cells are thus much more common than the other blood particles: there are about 4,000–11,000 [[white blood cells]] and about 150,000–400,000 [[platelet]]s per microliter.
 
Human red blood cells take on average 60 seconds to complete one cycle of circulation.<ref name="Blom20032" /><ref name=pierige/><ref>{{Cite book | last1 = Hillman | first1 = Robert S. | last2 = Ault | first2 = Kenneth A. | last3 = Rinder | first3 = Henry M. | year = 2005 | title = Hematology in Clinical Practice: A Guide to Diagnosis and Management | edition = 4 | publisher = McGraw-Hill Professional | page = 1 | isbn = 978-0-07-144035-6 }}</ref>