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There is insufficient evidence to determine that [[omega-3 fatty acid]] has any effect on depression.<ref>{{cite journal | vauthors = Appleton KM, Voyias PD, Sallis HM, Dawson S, Ness AR, Churchill R, Perry R | title = Omega-3 fatty acids for depression in adults | journal = The Cochrane Database of Systematic Reviews | volume = 2021 | issue = 11 | pages = CD004692 | date = November 2021 | pmid = 34817851 | pmc = 8612309 | doi = 10.1002/14651858.cd004692.pub5 | publisher = Wiley }}</ref> A 2016 review found that if trials with formulations containing mostly [[eicosapentaenoic acid]] (EPA) are separated from trials using formulations containing [[docosahexaenoic acid]] (DHA), it appeared that EPA may have an effect while DHA may not, but there was insufficient evidence to be sure.<ref>{{cite journal | vauthors = Hallahan B, Ryan T, Hibbeln JR, Murray IT, Glynn S, Ramsden CE, SanGiovanni JP, Davis JM | display-authors = 6 | title = Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression | journal = The British Journal of Psychiatry | volume = 209 | issue = 3 | pages = 192–201 | date = September 2016 | pmid = 27103682 | pmc = 9406129 | doi = 10.1192/bjp.bp.114.160242 | doi-access = free }}</ref>
A 2020 meta-analysis showed that a high dose of omega-3 polyunsaturated fatty acid (>
====Dopamine receptor agonist====
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