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Levetiracetam: Difference between revisions

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===Generalized epilepsy===
Levetiracetam is effective for treatment of generalized tonic-clonic epilepsy.<ref>{{cite journal | vauthorsname ="Cochrane_2022" Nevitt SJ, Sudell M, Weston J, Tudur Smith C, Marson AG | title = Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data | journal = The Cochrane Database of Systematic Reviews | volume = 2017 | issue = 12 | pages = CD011412 | date = December 2017 | pmid = 29243813 | pmc = 6486134 | doi = 10.1002/14651858.CD011412.pub3 }}</ref>{{Update inline|reason=Updated version https://www.ncbi.nlm.nih.gov/pubmed/35363878|date = July 2022}} It has been approved in the United States as add-on treatment for [[Seizure types#Generalized seizures|myoclonic]], and [[Seizure types#Generalized seizures|tonic-clonic]] seizures.<ref name="Keppra tablet FDA label" /> Levetiracetam has been approved in the European Union as a [[monotherapy]] treatment for epilepsy in the case of partial seizures or as an [[Combination therapy|adjunctive therapy]] for partial, myoclonic, and tonic-clonic seizures.<ref>{{cite book |title=BNF 59 |year=2010 |publisher=BMA & RPSGB}}</ref>
 
Levetiracetam is sometimes used off label to treat [[status epilepticus]].<ref>{{cite journal | vauthors = Brophy GM, Bell R, Claassen J, Alldredge B, Bleck TP, Glauser T, Laroche SM, Riviello JJ, Shutter L, Sperling MR, Treiman DM, Vespa PM | display-authors = 6 | title = Guidelines for the evaluation and management of status epilepticus | journal = Neurocritical Care | volume = 17 | issue = 1 | pages = 3–23 | date = August 2012 | pmid = 22528274 | doi = 10.1007/s12028-012-9695-z | s2cid = 4675838 | collaboration = Neurocritical Care Society Status Epilepticus Guideline Writing Committee }}</ref><ref>{{cite journal | vauthors = Meierkord H, Boon P, Engelsen B, Göcke K, Shorvon S, Tinuper P, Holtkamp M | title = EFNS guideline on the management of status epilepticus in adults | journal = European Journal of Neurology | volume = 17 | issue = 3 | pages = 348–355 | date = March 2010 | pmid = 20050893 | doi = 10.1111/j.1468-1331.2009.02917.x | s2cid = 1032139 | doi-access = free }}</ref>
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