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m =Metabolic disorders= |
m =Non-alcoholic Steato Hepatitis= |
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In severe cases of [[alpha 1-antitrypsin deficiency]] (A1AD), the acculumated [[protein]] causes in the [[endoplasmic reticulum]] causes liver cell damage and [[inflammation]]. This is technically not an autoimmune disease.
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Non-alcoholic Steato Hepatitis (NASH) is a type of hepatits which looks like alcoholic hepatitis on liver biopsy but is in a patient who does not have alcoholic liver disease as the cause. Liver biopsies in such patients have the appearance of alcoholic liver disease, with fat droplets, inflammatory cells, and Mallory's hyalin. The most common cause of this condition is obesity or the [[Metabolic syndrome]]. NASH is becoming recognized as the most important cause of liver disease second only to Hepatitis C in numbers os patients going on to [[cirrhosis]]. Diagnosis depends on history, blood tests, and a liver biopsy. It can be difficult to distinguish NASH from Alcoholic Hepatitis when the patient has a history of alcohol consumption. Some times in such cases a trial off alcohol, follow up blood tests, and a repeat liver biopsy are needed.
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