David Dane: Difference between revisions

| birth_date = {{Birth date|df=y|1923|3|25}}

| death_date = {{Death date and age|df=y|1998|4|9|1923|3|25}}

| workplaces = [[Queen's University Belfast]]<br>[[Middlesex Hospital Medical School]]

| fields = [[Pathology]]<br>[[Virology]]

During the later part of his professional career he and his [[Virology|Department of Virology]] at the [[Middlesex Hospital Medical School]] wherewere renowned for diagnostic precision irrespective of whether this involved dated technology, for example [[immunodiffusion|immunodiffusion (ID)]] or [[complement fixation tests|complement fixation tests (CFT)]], or state-of-the-art technology including [[radioimmunoassay|radioimmunoassay (RIA)]] and [[electron microscopy|electron microscopy (EM)]]. Whatever investigations were carried out were expected to be precise, accurate, reproducible and of clinical relevance.

David Maurice Surrey Dane was the son of William Surrey Dane (1892–1978), C.B.E., M.C., vice-chairman and managerial consultant of [[Odhams Press]] and chairman/ president of several hospital boards, including [[Great Ormond Street Hospital]] (1957–67), chairman of the [[Daily Herald (UK newspaper)|Daily Herald]] newspaper (1949–60), and a member of the General Advisory Council of the [[BBC]] (1956–62),<ref>Debrett's Peerage, Baronetage, Knightage and Companionage, 1973, Kelly's Directories, p. 2582</ref><ref>Who was Who entry, published online 2007 URL= http://oxfordindex.oup.com/view/10.1093/ww/9780199540884.013.U153703 {{Webarchive|url=https://web.archive.org/web/20180914165852/http://oxfordindex.oup.com/view/10.1093/ww/9780199540884.013.U153703 |date=14 September 2018 }} Date accessed= 14 Sep. 2018</ref> and his wife Dorothy Mary, daughter of Rev. William Alexander Armstrong, M.A. (Cantab.), vicar of West Dean, near Chichester; her brother was the artist [[John Armstrong (artist)|John Armstrong]].<ref>John Armstrong: The Paintings, Andrew Lambirth, Philip Wilson Publishing, 2009, p. 13</ref>

Dane attended [[Charterhouse School|Charterhouse School, Surrey]]. He was admitted to [[Clare College, Cambridge]], however, he volunteered instead to join the Army.<ref name="karger">Barbara, John A.J. (1998). David Surrey Dane. Retrieved from https://www.karger.com/Article/PDF/30982</ref> In 1941, heafter enlistedenlisting as a [[private (rank)|private]], Dane was selected for officer training. He joined the [[Parachute Regiment (United Kingdom)|Parachute Regiment]] in 1943, and then the newly formed [[Special Air Service|Special Air Service (SAS)]].<ref>"Second Supplement to The London Gazette - War Office, 16th October, 1942" (1942). Retrieved from: https://www.thegazette.co.uk/London/issue/35746/supplement/4486</ref> In July 1944, he was parachuted into [[France]] as part of [[Operation Bulbasket]].<ref>McCue, Paul (2009). SAS Operation Bulbasket: Behind the Lines in Occupied France. Barnsley, S. Yorks, UK: Pen and Sword Books Ltd. p. 232. {{ISBN|978-1-84884-193-2}}.</ref>

He returned to the UK to read [[Natural Sciences (Cambridge)|Natural Sciences]] at [[Clare College, Cambridge]] and later undertook his clinical medical training at [[St Thomas' Hospital]], London.<ref name="munks">>{{cite web|title=David Maurice Surrey Dane|url=http://munksroll.rcplondon.ac.uk/Biography/Details/4976|website=[[Royal College of Physicians]]|access-date=12 September 2016}}</ref>

Dane joined the [[Institute of Medical and Veterinary Science]], [[Adelaide]], in 1951 supported by a grant from [[NHS|National Health]] and the [[Medical Research Council (United Kingdom)|Medical Research Council]].<ref name="munks" /> He was instrumental in an extensive investigation of an undiagnosed outbreak of [[meningitis|acute meningitis]] and isolated a potential cause. It was inevitable that as a [[virologist|field virologist]] he would also become involved in the [[zoonosis|avian/human zoonosis]] of [[psittacosis]] work led by John Miles, Headhead of the Medical Research Division in the early 1950s.<ref>{{cite journal | last1 = Miles | first1 = J. A. R. | year = 1954 | title = Benign lymphocytic meningitis | journal = Medical Journal of Australia | volume = 1 | issue = 18| pages = 659–64 | doi = 10.5694/j.1326-5377.1954.tb85712.x | pmid = 13164668 | s2cid = 42301490 }}</ref> Dane continued to work to improve diagnostic methods and published on avian and human psittacosis.<ref>Dane, D. S., Miles, J. A. R., & Stoker, M. G. P. (1953). A disease of Manx Shearwaters: further observations in the field. The Journal of Animal Acology, 123-133.</ref>

On returning to the UK, in 1955, Dane was appointed [[lecturer]] in [[microbiology]] at [[Queen’sQueen's University Belfast]],<ref name="munks" /> where he worked with [[George Frederick Dick|Professor George Dick]] on the recently developed [[Attenuated vaccine|attenuate]] and [[Inactivated vaccine|killed]] [[poliovirus vaccines]].<ref>{{cite journal | last1 = Dick | first1 = GWA | last2 = Dane | first2 = DS | year = 1959 | title = Live Poliomyelitis Vaccine | journal = British Medical Journal | volume = 1 | issue = 5125| pages = 853–854 | doi = 10.1136/bmj.1.5125.853 | s2cid = 41758522 }}</ref> Through their research they established that the early live [[polio vaccines]] developed by [[Hilary Koprowski]] were unsafe because they could return to [[virulence]] when excreted by people given the vaccine.<ref>{{cite journal | last1 = Dane | first1 = DS | last2 = Dick | first2 = GWA | last3 = Briggs | first3 = M | last4 = Nelson | first4 = R | year = 1958 | title = Vaccination Against Poliomyelitis with Live Virus Vaccines | journal = British Medical Journal | volume = 2 | issue = 5106| pages = 1187–1188 | doi = 10.1136/bmj.2.5106.1187 | pmid = 13584893 | pmc = 2027199 }}</ref> Professor Dick’s team also initiated studies of combined [[diphtheria]]/[[pertussis]]/[[tetanus]] vaccines.<ref>{{cite journal | last1 = Haire | first1 = M | last2 = Dane | first2 = DS | last3 = Dick | first3 = G | last4 = Briggs | first4 = EM | last5 = Connor | first5 = TJ | year = 1966 | title = Further studies with a diphtheria-tetanus-poliomyelitis vaccine | journal = The Journal of Hygiene | volume = 64 | issue = 4| pages = 485–488 | doi = 10.1017/s0022172400040791 | pmid = 5224766 | pmc = 2134759 }}</ref>

In 1966, Dane left [[Belfast]] to become the head of the Virology Department, Bland Sutton School of Pathology at the [[Middlesex Hospital Medical School]], [[London]]. At that time this was one of the very few medical schools to have an [[electron microscope]], donated by [[Polio]] charities in recognition of his work in this field. Very much in character, he developed productive collaborations with senior colleagues within the medical school and hospital. Together with Dr Duncan Catterall, head of the [[sexually transmitted disease]] clinic in James Pringle House at [[Middlesex Hospital]], Dane quickly demonstrated the usefulness of the [[electron microscope]] for the rapid [[diagnosis]] of [[HIV|herpes simplex virus infection (HIV)]].<ref>{{cite journal | last1 = Fulford | first1 = K. W. M. | last2 = Dane | first2 = D. S. | last3 = Catterall | first3 = R. D. | last4 = Woof | first4 = R. | last5 = Denning | first5 = J. V. | year = 1973 | title = Australia antigen and antibody among patients attending a clinic for sexually transmitted diseases | journal = The Lancet | volume = 301 | issue = 7818| pages = 1470–1473 | doi = 10.1016/s0140-6736(73)91810-2 | pmid = 4123139 }}</ref> Close collaborations with two senior colleagues in the [[haematology]] field, [[James Wallace Stewart|James Wallace "Jimmie" Stewart]], Professor of Haematology at the [[Middlesex Hospital Medical School|Middlesex Hospital Medical School (MHMS)]], and Tom Cleghorn, Directordirector of the North London Blood Transfusion Centre (NLBTC) at [[Edgware]] led to ground-breaking work in the emerging field of [[transfusion transmitted infection]] and particularly that of post-transfusion hepatitis.<ref>Doniach, D., Del Prete, S., Dane, D. S., & Walsh, J. H. (1972). "Viral hepatitis related antigens in 'autoimmune' hepatic disorders", ''Canadian Medical Association Journal'', 106 (Spec Issue), 513.</ref>

In 1955, Dane married Veronica (née Tester), widow of Maj. Iain Herford Hope (1918–1951);<ref>{{cite news |newspaper=The Advertiser (Adelaide) |date=4 August 1951 |page=3 |title=Military funeral for R.A. Officer |url= https://trove.nla.gov.au/newspaper/article/45726903 |access-date=14 September 2018 }}</ref> she had two children, Kerin and Alex. They had met in Australia. Together they had three children: [[Roland Dane|Roland]], Penelope and Thomas. Dane died in April 1998.

[[Category:Academics of Queen’sQueen's University Belfast]]