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Amiodarone is sometimes responsible for [[epididymitis]]. Amiodarone accumulates in the head of the organ and can cause unilateral or bilateral inflammation. It tends to resolve if amiodarone is stopped.<ref>{{cite journal | vauthors = Thomas A, Woodard C, Rovner ES, Wein AJ | title = Urologic complications of neurologic medications | journal = The Urologic Clinics of North America | volume = 30 | issue = 1 | pages = 123–131 | date = February 2003 | pmid = 12580564 | doi = 10.1016/S0094-0143(02)00111-8 }}</ref>
Some cases of [[gynecomastia]] have been reported in men on amiodarone.<ref name="Gynecomastia: Its features, and when and how to treat it">[http://www.ccjm.org/content/71/6/511.full.pdf] {{Webarchive|url=https://web.archive.org/web/20090709184316/http://www.ccjm.org/content/71/6/511.full.pdf |date=9 July 2009 }} Gynecomastia: Its features, and when and how to treat it</ref>
ThereA isTaiwanese aretrospective possiblecohort associationstudy between amiodarone andfound an increased risk of cancerdigestive, especiallyliver, head and neck and liver cancers amongst male patients exposed to Amiodarone versus female patients in males,the withsame astudy [[Dose–responseand relationship|dose-dependent]]the effect.general population<ref name=":0">{{cite journal | vauthors = Su VY, Hu YW, Chou KT, Ou SM, Lee YC, Lin EY, Chen TJ, Tzeng CH, Liu CJ |date=May title2013 |title= Amiodarone and the risk of cancer: a nationwide population-based study | journal = Cancer | volume = 119 | issue = 9 | pages = 1699–1705 | date = May 2013 | pmid = 23568847 | doi = 10.1002/cncr.27881 |pmid=23568847 |s2cid = 24144312 | doi-access = free }}</ref>. This study also identified that the Standardized Incidence Ratio (SIR) of cancer occurrence increased significantly in males aged 20-59 and >80 years old who were exposed to a higher dose of Amiodarone in comparison to those exposed to a lower dose. This suggests that there is a dose-effect relationship<ref name=":0" />. These results should be interpreted with caution due to limitations of the study design and care should be taken prior to altering current clinical and prescribing practices. Amiodarone and its effect on cancer is still a topic that requires more robust research.
== Drug-drug interactions ==
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