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Prevention is by [[safe sex]] to prevent syphilis in the mother, and early screening and treatment of syphilis in pregnancy.<ref name=CDCfact/> Treatment is with [[penicillin]] by injection; [[benzylpenicillin]] [[intravenous injection|into vein]], or [[procaine benzylpenicillin]] or [[Benzathine benzylpenicillin|benzathine penicillin G]] [[intramuscular injection|into muscle]].<ref name=Ferri2022>{{cite book |last1=Ferri |first1=Fred F. |title=Ferri's Clinical Advisor 2022 |date=2022 |publisher=Elsevier |location=Philadelphia |isbn=978-0-323-75571-9 |pages=1452-1454 |chapter-url=https://books.google.com/books?id=VW4yEAAAQBAJ&pg=PA1454 |language=en |chapter=Syphilis}}</ref><ref name=CDCRx/> During times of penicillin unavailability, [[ceftriaxone]] may be an alternative.<ref name=CDCRx/> Where there is [[side effects of penicillin|penicillin allergy]], antimicrobial desensitisation may be considered.<ref name=CDCRx/><ref name=Chastain2019>{{cite journal |last1=Chastain |first1=DB |last2=Hutzley |first2=VJ |last3=Parekh |first3=J |last4=Alegro |first4=JVG |title=Antimicrobial Desensitization: A Review of Published Protocols. |journal=Pharmacy (Basel, Switzerland) |date=9 August 2019 |volume=7 |issue=3 |doi=10.3390/pharmacy7030112 |pmid=31405062 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789802/}}</ref>
In 2016, there were around 473 cases of congenital syphilis per 100,000 live births and 204,000 deaths from the disease worldwide.<ref name=WHO2021>{{cite book |title=Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021 |date=2021 |publisher=World Health Organization
==Signs and symptoms==
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