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Congenital syphilis: Difference between revisions

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penicillin allergy
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Prevention is by [[safe sex]] to prevent syphilis in the mother, and early screening and treatment of syphilis in pregnancy.<ref name=CDCfact/> Treatment is with [[penicillin]] by injection; [[benzylpenicillin]] [[intravenous injection|into vein]], or [[procaine benzylpenicillin]] or [[Benzathine benzylpenicillin|benzathine penicillin G]] [[intramuscular injection|into muscle]].<ref name=Ferri2022>{{cite book |last1=Ferri |first1=Fred F. |title=Ferri's Clinical Advisor 2022 |date=2022 |publisher=Elsevier |location=Philadelphia |isbn=978-0-323-75571-9 |pages=1452-1454 |chapter-url=https://books.google.com/books?id=VW4yEAAAQBAJ&pg=PA1454 |language=en |chapter=Syphilis}}</ref><ref name=CDCRx/> During times of penicillin unavailability, [[ceftriaxone]] may be an alternative.<ref name=CDCRx/> Where there is [[side effects of penicillin|penicillin allergy]], antimicrobial desensitisation may be considered.<ref name=CDCRx/><ref name=Chastain2019>{{cite journal |last1=Chastain |first1=DB |last2=Hutzley |first2=VJ |last3=Parekh |first3=J |last4=Alegro |first4=JVG |title=Antimicrobial Desensitization: A Review of Published Protocols. |journal=Pharmacy (Basel, Switzerland) |date=9 August 2019 |volume=7 |issue=3 |doi=10.3390/pharmacy7030112 |pmid=31405062 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789802/}}</ref>
 
In 2016, there were around 473 cases of congenital syphilis per 100,000 live births and 204,000 deaths from the disease worldwide.<ref name=WHO2021>{{cite book |title=Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021 |date=2021 |publisher=World Health Organization; |location=Geneva |isbn=978-92-4-003098-5 |url=https://apps.who.int/iris/bitstream/handle/10665/342808/9789240030985-eng.pdf |language=en |access-date=2023-05-08 }}</ref> Of the 660,000 cases reported in 2016, 143,000 resulted in deaths of unborn babies, 61,000 deaths of newborn babies, 41,000 low birth weights or preterm births, and 109,000 [[infant|young children]] diagnosed with congenital syphilis.<ref name=WHO>{{cite web |title=Congenital syphilis - Mother-to-child transmission of syphilis |url=https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/stis/prevention/mother-to-child-transmission-of-syphilis |website=www.who.int |accessdate=9 May 2023 |language=en }}</ref>
 
==Signs and symptoms==