* [[July 2]] – [[Eighty Years' War]] (Dutch War of Independence) – [[Battle of Nieuwpoort]]: The [[Dutch Republic]] gains a tactical victory over the [[Spanish Empire]].<ref>{{cite web|url=http://www.historyorb.com/events/date/1600 |title=Historical Events for Year 1600 | OnThisDay.com |website=Historyorb.com |access-date=2018-04-05}}</ref>
* [[August 5]] – The brothers [[Alexander Ruthven]] and [[John Ruthven, 3rd Earl of Gowrie]], are killed during a failed attempt to kidnap or murder [[James VI and I|King James VI of Scotland]] at their home.
* Autumn
** [[Persian embassy to Europe (1599–1602)|A Persian embassy]] arrives in [[Prague]] and meets with [[Rudolf II, Holy Roman Emperor]].
* [[October 6]] – Première of [[Jacopo Peri]]'s ''[[Euridice (Peri)|Euridice]]'', the earliest known fully surviving work of modern opera, produced by [[Emilio de' Cavalieri]] for the wedding of [[Henry IV of France]] and [[Maria de' Medici]] in [[Florence]].<ref>{{cite book|author=John Glenn Paton|title=Italian Arias of the Baroque and Classical Eras: High|url=https://books.google.com/books?id=dDy-RgkSf8UC&pg=PA10|year=1994|publisher=Alfred Music Publishing|isbn=978-0-7390-2191-0|pages=10|language=en}}</ref>
* [[October 20]] – [[Persian embassy to Europe (1599–1602)|Persian diplomats]], led by Husayn 'Ali Beg of Persia, and Englishman [[Anthony Shirley]] (who serves as translator) arrive in [[Prague]] to meet with [[Rudolf II, Holy Roman Emperor]]. <ref name=Sherley>("Dispatch of 23rd October, 1600: On the 20th the two ambassadors from Persia made their entry here; one is an Englishman called, as I understand, he is the principal Ambassador, and the other is a Persian called Assan Halevech; there are about twenty or twenty-five persons with them...") contemporary account, quoted in ''Sir Anthony Sherley and His Persian Adventure'', ed by Edward D. Ross (RoutledgeCurzon, 2005) p. 23-24 </ref>
* [[October 21]] – [[Battle of Sekigahara]]: inThe Japan:Shogan [[Tokugawa Ieyasu]] gains nominal control over the whole countryJapan.
* [[November 7]] — [[Rudolf II, Holy Roman Emperor|Emperor Rudolf II]] grants an audience in [[Prague]] to Persian diplomats Husayn 'Ali Beg and Anthony Shirley, and present the offer of Persia's King [[Abbas the Great]] to supply weapons to the Empire in their fight against the Ottomans. <ref name=Sherley/> <ref>("Dispatch of November 8th, 1600: "Yesterday these Ambassadors from the King of Persia had had an audience. The Englishman spoke in Spanish, and the substance of that King's offer to His Imperial Majesty was that he would arm against the Turk...")</ref>
* [[November 15]] — [[Thessaly rebellion (1600)|Thessaly rebellion]]: Greek farmers in Thessaly, incited by Bishop [[Dionysios Skylosophos]], begin an uprising against the [[Ottoman Empire]], with violence in an area bounded by [[Trikala]] and [[Karditsa]] and the surrounding mountains, but the rebellion is suppressed by the Ottomans in a few days <ref>[https://web.archive.org/web/20180907115517/https://www.tanea.gr/2000/08/17/grece/dionysios-o-filosofos-mitropolitis-larisis/ "Dionysios the Philosopher, Metropolitan of Larissa"], by Georgios Ploumidis, in ''[[Ta Nea]] (Athens)'', August 17, 2000, archived by Archive.org
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