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'{{Short description|British microbiologist}} {{Infobox scientist | name = Lesley Hoyles | birth_date = {{Birth year and age|1974}} | workplaces = University College Cork <br> Imperial College London <br> [[Nottingham Trent University]] | alma_mater = [[University College Cork]] <br> [[Imperial College London]] <br> [[University of Reading]] | thesis_title = In vitro examination of the effect of orlistat on the ability of the faecal microbiota to utilize dietary lipids. | thesis_url = http://www.worldcat.org/oclc/757100740 | thesis_year = 2009 }} '''Lesley Hoyles''' (born 1974) is a British microbiologist who is a professor at [[Nottingham Trent University]]. She combines ''in vivo'' and ''in vitro'' microbiology and bioinformatics research to better understand how gut microbiota influence health and disease. == Early life and education == Hoyles was born in [[Swansea]].<ref name=":3">{{Cite journal|last=Hoyles|first=Lesley|date=2019-07-01|title=Spotlight on… Lesley Hoyles|url=https://academic.oup.com/femsle/article/doi/10.1093/femsle/fnz156/5550821|journal=FEMS Microbiology Letters|language=en|volume=366|issue=13|pages=fnz156|doi=10.1093/femsle/fnz156|issn=1574-6968}}</ref> She was an undergraduate student in chemistry and food science at the [[University of Reading]].<ref name=":3" /> She switched her specialism to biochemistry after a year.<ref name=":3" /> After graduating, she trained as a taxonomist in the Institute of Food Research, where she studied Gram-positive anaerobes which had isolated form clinical sources.<ref name=":0">{{Cite web|title=Lesley Hoyles|url=https://www.ntu.ac.uk/staff-profiles/science-technology/lesley-hoyles|access-date=2022-02-15|website=www.ntu.ac.uk|language=en}}</ref> Hoyles remained at the University of Reading for postgraduate research, working in the laboratory of [[Glenn Gibson]] as a [[GlaxoSmithKline]] researcher.<ref>{{Cite book|last=Hoyles|first=Lesley|url=https://www.worldcat.org/title/in-vitro-examination-of-the-effect-of-orlistat-on-the-ability-of-the-faecal-microbiota-to-utilize-dietary-lipids/oclc/757100740|title=In vitro examination of the effect of orlistat on the ability of the faecal microbiota to utilize dietary lipids.|last2=University of Reading|date=2009|publisher=University of Reading|language=English|oclc=757100740}}</ref> Her early worked considered ''[[Actinobaculum]]'' and the role of anti-obesity therapy on human gut microbiota.<ref name=":0" /> During her research, she became aware of the gut microbiome. She was appointed a research fellow as part of the Government of Ireland Postdoctoral Fellowship in Science, Engineering and Technology scheme, and joined [[Douwe van Sinderen]] at the [[University College Cork]].<ref name=":0" /> This position inspired to develop advanced characterisation protocols to better understand bacteriophages. She was awarded a [[Medical Research Council (United Kingdom)|Medical Research Council]] scholarship to undertake a master's degree in bioinformatics at [[Imperial College London]].<ref name=":0" /><ref name=":1">{{Cite web|title=Home - Professor Lesley Hoyles|url=https://www.imperial.ac.uk/people/lesley.hoyles11|access-date=2022-02-15|website=www.imperial.ac.uk}}</ref> == Research and career == Hoyles' early research considered the isolation and characterisation of anaerobic ''[[Actinobaculum]]''. After completing her master's degree at [[Imperial College London]], she worked on translational systems biology as a postdoctoral research associate<ref name=":1" /> and started to investigate host–microbiome interactions.<ref name=":1"/> In 2014, Hoyles was appointed a lecturer at the [[University of Westminster]].<ref name=":0" /> In 2018, she joined [[Nottingham Trent University]] as an associate professor in microbiology. She was promoted to full Professor in 2020.<ref name=":0" /> Hoyles is involved with microbiome research. Specifically, she combines ''in vivo'' and ''in vitro'' microbiology and bioinformatics approaches to uncover the role of gut microbiota in health. She has defined the contributions of the gut microbiome to various conditions, including [[non-alcoholic fatty liver disease]],<ref>{{Cite journal|last=Hoyles|first=Lesley|last2=Fernández-Real|first2=José-Manuel|last3=Federici|first3=Massimo|last4=Serino|first4=Matteo|last5=Abbott|first5=James|last6=Charpentier|first6=Julie|last7=Heymes|first7=Christophe|last8=Luque|first8=Jèssica Latorre|last9=Anthony|first9=Elodie|last10=Barton|first10=Richard H.|last11=Chilloux|first11=Julien|date=July 2018|title=Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women|url=https://www.nature.com/articles/s41591-018-0061-3|journal=Nature Medicine|language=en|volume=24|issue=7|pages=1070–1080|doi=10.1038/s41591-018-0061-3|issn=1546-170X}}</ref> the status of the [[blood–brain barrier]]<ref>{{Cite journal|last=Hoyles|first=Lesley|last2=Snelling|first2=Tom|last3=Umlai|first3=Umm-Kulthum|last4=Nicholson|first4=Jeremy K.|last5=Carding|first5=Simon R.|last6=Glen|first6=Robert C.|last7=McArthur|first7=Simon|date=2018-03-21|title=Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier|url=https://pubmed.ncbi.nlm.nih.gov/29562936/|journal=Microbiome|volume=6|issue=1|pages=55|doi=10.1186/s40168-018-0439-y|issn=2049-2618|pmc=5863458|pmid=29562936}}</ref> and metabolic retroconversion.<ref>{{Cite journal|last=Hoyles|first=Lesley|last2=Jiménez-Pranteda|first2=Maria L.|last3=Chilloux|first3=Julien|last4=Brial|first4=Francois|last5=Myridakis|first5=Antonis|last6=Aranias|first6=Thomas|last7=Magnan|first7=Christophe|last8=Gibson|first8=Glenn R.|last9=Sanderson|first9=Jeremy D.|last10=Nicholson|first10=Jeremy K.|last11=Gauguier|first11=Dominique|date=2018-04-20|title=Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909246/|journal=Microbiome|volume=6|pages=73|doi=10.1186/s40168-018-0461-0|issn=2049-2618|pmc=5909246|pmid=29678198}}</ref> Hoyles identified that [[Trimethylamine N-oxide]] (TMAO), a molecule found in fish and seafood, may play a role in improving cognitive function by strengthening the blood–brain barrier.<ref>{{Cite web|date=2021-12-07|title=Molecule in fish ‘plays role in protecting and improving cognitive function’|url=https://www.independent.co.uk/news/uk/queen-mary-university-of-london-nottingham-trent-university-b1971024.html|access-date=2022-02-15|website=The Independent|language=en}}</ref><ref>{{Cite web|title=Molecule found in seafood plays role in protecting and improving cognitive function, researchers find|url=https://www.qmul.ac.uk/media/news/2021/smd/molecule-found-in-seafood-plays-role-in-protecting-and-improving-cognitive-function-researchers-find.html|access-date=2022-02-15|website=Queen Mary University of London|language=en}}</ref> In an effort to restore cognitive function to older people, Hoyles evaluated the impact of fecal transplants on the microbiome, spatial learning and memory of mice.<ref name=":2">{{Cite web|title=Could a fecal transplant one day be the secret of eternal youth?|url=https://www.sciencedaily.com/releases/2020/10/201002091049.htm|access-date=2022-02-15|website=ScienceDaily|language=en}}</ref> She showed that young mice who had fecal transplants from older mice had impaired spatial learning, memory and altered levels of the proteins associated with synaptic plasticity.<ref name=":2" /> == Selected publications == * {{Cite Q|Q34141652}} * {{Cite Q|Q34481919}} * {{Cite Q|Q34654550}} == Personal life == Hoyles' nine month old brother passed away when she was eight years old, which left her with anxiety.<ref name=":3" /> She engaged in a [[Civil partnership in the United Kingdom|civil partnership]] with her wife in 2010.<ref name=":3" /><ref>{{Cite web|date=2017-08-17|title=An interview with Lesley Hoyles|url=https://lgbtstem.wordpress.com/2017/08/17/an-interview-with-lesley-hoyles/|access-date=2022-02-15|website=LGBTQ+ STEM|language=en}}</ref><ref>{{Cite web|title=Diverse Sources {{!}} Science, Health and Environment experts available on deadline|url=https://diversesources.org/sources/669/lesley-hoyles/|access-date=2022-02-15|website=diversesources.org|language=en}}</ref> == References == {{reflist}} {{Authority control}} {{DEFAULTSORT:Hoyles, Lesley}} [[Category:Living people]] [[Category:1974 births]] [[Category:Microbiologists]] [[Category:Alumni of University College Cork]] [[Category:Alumni of Imperial College London]] [[Category:Alumni of the University of Reading]] [[Category:People from Swansea]] [[Category:Academics of Nottingham Trent University]] [[Category:British women scientists]] [[Category:21st-century British scientists]]'