Thymolphthalein: Difference between revisions
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{{pH_indicator_template|indicator_name=Thymolphthalein |low_pH=<0 |high_pH=9.3|low_pH_color=red|high_pH_color=white|high_pH_text=black}} |
{{pH_indicator_template|indicator_name=Thymolphthalein |low_pH=<0 |high_pH=9.3|low_pH_color=red|high_pH_color=white|high_pH_text=black}} |
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Thymolphthalein is also known to have use as a [[laxative]] <ref>{{cite journal | last1 = Hubacher | first1 = MH | last2 = Doernberg | first2 = S | last3 = Horner | first3 = A | year = 1953 | title = Laxatives: chemical structure and potency of phthaleins and hydroxyanthraquinones |
Thymolphthalein is also known to have use as a [[laxative]] <ref>{{cite journal | last1 = Hubacher | first1 = MH | last2 = Doernberg | first2 = S | last3 = Horner | first3 = A | year = 1953 | title = Laxatives: chemical structure and potency of phthaleins and hydroxyanthraquinones | journal = J Am Pharm Assoc Am Pharm Assoc | volume = 42 | issue = 1| pages = 23–30 | pmid = 13034620 | doi = 10.1002/jps.3030420108 }}</ref> and for [[disappearing ink]].<ref>{{Cite web|url=http://www.chymist.com/Disappearing%20Ink.pdf|title=Disappearing Ink|last=Katz|first=David A.|date=1982|website=www.chymist.com|access-date=August 14, 2017}}</ref> |
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==Preparation== |
==Preparation== |
Revision as of 17:40, 11 December 2020
Names | |
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IUPAC name
3,3-bis(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-2-benzofuran-1-one
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.004.300 |
EC Number |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C28H30O4 | |
Molar mass | 430.544 g·mol−1 |
Appearance | White powder |
Melting point | 248 to 252 °C (478 to 486 °F; 521 to 525 K) (decomposes) |
Hazards | |
NFPA 704 (fire diamond) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Thymolphthalein is a phthalein dye used as an acid–base (pH) indicator. Its transition range is around pH 9.3–10.5. Below this pH, it is colorless; above, it is blue. The molar extinction coefficient for the blue thymolphthalein dianion is 38,000 M−1 cm−1 at 595 nm.[1]
Thymolphthalein (pH indicator) | ||
below pH 9.3 | above pH 10.5 | |
9.3 | ⇌ | 10.5 |
Thymolphthalein (pH indicator) | ||
below pH <0 | above pH 9.3 | |
<0 | ⇌ | 9.3 |
Thymolphthalein is also known to have use as a laxative [2] and for disappearing ink.[3]
Preparation
Thymolphthalein can be synthesized from thymol and phthalic anhydride
References
- ^ Hahn HH; Cheuk SF; Elfenbein S; Wood WB (April 1970). "Studies on the Pathogenesis of Fever: Xix. Localization of Pyrogen in Granulocytes". J. Exp. Med. 131 (4): 701–9. doi:10.1084/jem.131.4.701. PMC 2138774. PMID 5430784.
- ^ Hubacher, MH; Doernberg, S; Horner, A (1953). "Laxatives: chemical structure and potency of phthaleins and hydroxyanthraquinones". J Am Pharm Assoc Am Pharm Assoc. 42 (1): 23–30. doi:10.1002/jps.3030420108. PMID 13034620.
- ^ Katz, David A. (1982). "Disappearing Ink" (PDF). www.chymist.com. Retrieved August 14, 2017.