Thymolphthalein: Difference between revisions
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Revision as of 06:10, 30 October 2014
Names | |
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IUPAC name
3,3-bis(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-2-benzofuran-1-one
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.004.300 |
EC Number |
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C28H30O4 | |
Molar mass | 430.544 g·mol−1 |
Appearance | White powder |
Melting point | 248 - 252 °C (decomp.) |
Hazards | |
NFPA 704 (fire diamond) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Thymolphthalein is an acid-base (pH) indicator. Its transition range is around pH 9.3-10.5. Below this pH, it is colorless; above, it is blue. The molar extinction coefficient for the blue thymolphthalein dianion is 38000 M-1cm-1 at 595 nm.[1]
Thymolphthalein (pH indicator) | ||
below pH 9.3 | above pH 10.5 | |
9.3 | ⇌ | 10.5 |
Preparation
Thymolphthalein can be synthesized from thymol and phthalic anhydride by Friedel-Crafts alkylation:
References
- ^ Hahn HH, Cheuk SF, Elfenbein S, Wood WB (April 1970). "Studies on the Pathogenesis of Fever: Xix. Localization of Pyrogen in Granulocytes" (PDF). J. Exp. Med. 131 (4): 701–9. doi:10.1084/jem.131.4.701. PMC 2138774. PMID 5430784.
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