Tenascin-R

TNR
Identifiers
Aliases	TNR, TN-R, tenascin R, NEDSTO
External IDs	OMIM: 601995; MGI: 99516; HomoloGene: 124416; GeneCards: TNR; OMA:TNR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	175,743,616 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	159,759,299 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; entorhinal cortex; ; inferior ganglion of vagus nerve; ; medulla oblongata; ; subthalamic nucleus; ; superior vestibular nucleus; ; ventral tegmental area; ; postcentral gyrus; ; inferior olivary nucleus; ; pars reticulata;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; primary visual cortex; ; superior frontal gyrus; ; ciliary body; ; iris; ; facial motor nucleus; ; neural layer of retina; ; hippocampus proper; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cell surface; membrane raft; perineuronal net; collagen-containing extracellular matrix; extracellular matrix; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	negative regulation of neuron projection development; positive regulation of synaptic transmission, glutamatergic; extracellular matrix organization; axon guidance; synapse organization; positive regulation of transmission of nerve impulse; neuron cell-cell adhesion; negative regulation of cell-cell adhesion; telencephalon cell migration; negative regulation of axon extension; locomotory exploration behavior; long-term potentiation; neuromuscular process controlling balance; regulation of neurogenesis; negative regulation of axon extension involved in regeneration; negative regulation of synaptic transmission; modulation of chemical synaptic transmission; associative learning; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	7143
	21960
	ENSG00000116147
	ENSMUSG00000015829
	Q92752
	Q8BYI9
	NM_003285; NM_001328635
	NM_022312
	NP_001315564; NP_003276; NP_003276.3
	NP_071707
	Wikidata
View/Edit Human	View/Edit Mouse

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Tenascin-R is a protein that in humans is encoded by the TNR gene.^[5]^[6]^[7]

Function

Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes 4 genes in mammals: TNC (or hexabrachion), TNX (TNXB), TNW (also known as TNN) and TNR.^[8]^[9] The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116147 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015829 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carnemolla B, Leprini A, Borsi L, Querzé G, Urbini S, Zardi L (April 1996). "Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24". The Journal of Biological Chemistry. 271 (14): 8157–60. doi:10.1074/jbc.271.14.8157. PMID 8626505.
^ Leprini A, Gherzi R, Siri A, Querzé G, Viti F, Zardi L (December 1996). "The human tenascin-R gene". The Journal of Biological Chemistry. 271 (49): 31251–4. doi:10.1074/jbc.271.49.31251. PMID 8940128.
^ ^a ^b "Entrez Gene: TNR tenascin R (restrictin, janusin)".
^ Erickson HP (October 1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Current Opinion in Cell Biology. 5 (5): 869–76. doi:10.1016/0955-0674(93)90037-Q. PMID 7694605.
^ Hsia, Henry C.; Schwarzbauer, Jean E. (July 2005). "Meet the Tenascins: Multifunctional and Mysterious". Journal of Biological Chemistry. 280 (29): 26641–26644. doi:10.1074/jbc.R500005200. PMID 15932878.

Erickson HP (October 1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Current Opinion in Cell Biology. 5 (5): 869–76. doi:10.1016/0955-0674(93)90037-Q. PMID 7694605.
Xiao ZC, Taylor J, Montag D, Rougon G, Schachner M (April 1996). "Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11". The European Journal of Neuroscience. 8 (4): 766–82. doi:10.1111/j.1460-9568.1996.tb01262.x. PMID 9081628. S2CID 30389358.
Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (September 1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10116–21. Bibcode:1997PNAS...9410116A. doi:10.1073/pnas.94.19.10116. PMC 23322. PMID 9294172.
Xiao ZC, Hillenbrand R, Schachner M, Thermes S, Rougon G, Gomez S (September 1997). "Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R". Journal of Neuroscience Research. 49 (6): 698–709. doi:10.1002/(SICI)1097-4547(19970915)49:6<698::AID-JNR4>3.0.CO;2-2. PMID 9335257. S2CID 10209383.
Arrigo G, Gherzi R, Bonaglia MC, Leprini A, Zuffardi O, Zardi L (1997). "Assignment of the tenascin-R gene (Tnr) to mouse chromosome 4 band E2 by fluorescence in situ hybridization; refinement of the human TNR location to chromosome 1q24". Cytogenetics and Cell Genetics. 78 (2): 145–6. doi:10.1159/000134650. PMID 9371410.
Volkmer H, Zacharias U, Nörenberg U, Rathjen FG (August 1998). "Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells". The Journal of Cell Biology. 142 (4): 1083–93. doi:10.1083/jcb.142.4.1083. PMC 2132869. PMID 9722619.
Zamze S, Harvey DJ, Pesheva P, Mattu TS, Schachner M, Dwek RA, Wing DR (August 1999). "Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans". Glycobiology. 9 (8): 823–31. doi:10.1093/glycob/9.8.823. hdl:20.500.11850/422721. PMID 10406848.
Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (January 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (December 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Woodworth A, Pesheva P, Fiete D, Baenziger JU (March 2004). "Neuronal-specific synthesis and glycosylation of tenascin-R". The Journal of Biological Chemistry. 279 (11): 10413–21. doi:10.1074/jbc.M312466200. PMID 14681222.
Bukalo O, Schachner M, Dityatev A (May 2007). "Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R". The Journal of Neuroscience. 27 (22): 6019–28. doi:10.1523/JNEUROSCI.1022-07.2007. PMC 6672247. PMID 17537973.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116147 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015829 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8626505-5] Carnemolla B, Leprini A, Borsi L, Querzé G, Urbini S, Zardi L (April 1996). "Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24". The Journal of Biological Chemistry. 271 (14): 8157–60. doi:10.1074/jbc.271.14.8157. PMID 8626505.

[pmid8940128-6] Leprini A, Gherzi R, Siri A, Querzé G, Viti F, Zardi L (December 1996). "The human tenascin-R gene". The Journal of Biological Chemistry. 271 (49): 31251–4. doi:10.1074/jbc.271.49.31251. PMID 8940128.

[entrez-7] "Entrez Gene: TNR tenascin R (restrictin, janusin)".

[pmid7694605-8] Erickson HP (October 1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Current Opinion in Cell Biology. 5 (5): 869–76. doi:10.1016/0955-0674(93)90037-Q. PMID 7694605.

[9] Hsia, Henry C.; Schwarzbauer, Jean E. (July 2005). "Meet the Tenascins: Multifunctional and Mysterious". Journal of Biological Chemistry. 280 (29): 26641–26644. doi:10.1074/jbc.R500005200. PMID 15932878.

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Function

References

Further reading