TRAF1: Difference between revisions

'''TNF receptor-associated factor 1''' is a [[protein]] that in humans is encoded by the ''TRAF1'' [[gene]].<ref name="pmid8069916">{{cite journal | author = Rothe M, Wong SC, Henzel WJ, Goeddel DV | title = A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor | journal = Cell | volume = 78 | issue = 4 | pages = 681–92 |date=September 1994 | pmid = 8069916 | pmc = | doi =10.1016/0092-8674(94)90532-0 }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary

| section_title =

| summary_text = The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.<ref name="entrez">{{cite web | title = Entrez Gene: TRAF1 TNF receptor-associated factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7185| accessdate = }}</ref>

}}

==Interactions==

TRAF1 has been shown to [[Protein-protein interaction|interact]] with [[CD30]],<ref name=pmid8943059>{{cite journal |doi=10.1073/pnas.93.24.14053 |last=Ansieau |first=S |authorlink= |coauthors=Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J |date=November 1996 |title=Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=24 |pages=14053–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8943059 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=19493 }}{{Retracted paper}}</ref> [[CFLAR]],<ref name=pmid9208847>{{cite journal |doi=10.1016/S1074-7613(00)80450-1 |last=Shu |first=H B |authorlink= |author2=Halpin D R |author3=Goeddel D V |date=June 1997 |title=Casper is a FADD- and caspase-related inducer of apoptosis |journal=Immunity |volume=6 |issue=6 |pages=751–63 |publisher= |location = UNITED STATES| issn = 1074-7613| pmid = 9208847 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10837247>{{cite journal |doi=10.1016/S0960-9822(00)00512-1 |last=Kataoka |first=T |authorlink= |coauthors=Budd R C, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J |date=June 2000 |title=The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways |journal=Curr. Biol. |volume=10 |issue=11 |pages=640–8 |publisher= |location = ENGLAND| issn = 0960-9822| pmid = 10837247 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Baculoviral IAP repeat-containing protein 3]],<ref name=pmid9384571>{{cite journal |last=Roy |first=N |authorlink= |author2=Deveraux Q L |author3=Takahashi R |author4=Salvesen G S |author5=Reed J C |date=Dec 1997 |title=The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases |journal=EMBO J. |volume=16 |issue=23 |pages=6914–25 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9384571 |doi = 10.1093/emboj/16.23.6914 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1170295 }}</ref><ref name=pmid11907583>{{cite journal |last=Li |first=Xiaoming |authorlink= |author2=Yang Yili |author3=Ashwell Jonathan D |date=March 2002 |title=TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 |journal=[[Nature (journal)|Nature]] |volume=416 |issue=6878 |pages=345–7 |publisher= |location = England| issn = 0028-0836| pmid = 11907583 |doi = 10.1038/416345a | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BIRC2]],<ref name=pmid9384571/><ref name=pmid11907583/><ref name=pmid8943045>{{cite journal |doi=10.1073/pnas.93.24.13973 |last=Shu |first=H B |authorlink= |author2=Takeuchi M |author3=Goeddel D V |date=November 1996 |title=The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=24 |pages=13973–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8943045 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=19479 }}</ref> [[Caspase 8]],<ref name=pmid12887920>{{cite journal |doi=10.1016/S0092-8674(03)00521-X |last=Micheau |first=Olivier |authorlink= |author2=Tschopp Jürg |date=July 2003 |title=Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes |journal=Cell |volume=114 |issue=2 |pages=181–90 |publisher= |location = United States| issn = 0092-8674| pmid = 12887920 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11098060>{{cite journal |last=Leo |first=E |authorlink= |author2=Deveraux Q L |author3=Buchholtz C |author4=Welsh K |author5=Matsuzawa S |author6=Stennicke H R |author7=Salvesen G S |author8=Reed J C |date=March 2001 |title=TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis |journal=J. Biol. Chem. |volume=276 |issue=11 |pages=8087–93 |publisher= |location = United States| issn = 0021-9258| pmid = 11098060 |doi = 10.1074/jbc.M009450200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HIVEP3]],<ref name=pmid11804591>{{cite journal |doi=10.1016/S1097-2765(01)00434-8 |last=Oukka |first=Mohamed |authorlink= |author2=Kim Sean T |author3=Lugo Geancarlo |author4=Sun Jenny |author5=Wu Lai-Chu |author6=Glimcher Laurie H |date=January 2002 |title=A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2 |journal=Mol. Cell |volume=9 |issue=1 |pages=121–31 |publisher= |location = United States| issn = 1097-2765| pmid = 11804591 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TNFAIP3]],<ref name=pmid8692885>{{cite journal |doi=10.1073/pnas.93.13.6721 |last=Song |first=H Y |authorlink= |author2=Rothe M |author3=Goeddel D V |date=June 1996 |title=The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=13 |pages=6721–5 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8692885 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=39093 }}</ref><ref name=pmid9928991>{{cite journal |doi=10.1016/S0014-5793(98)01645-7 |last=Heyninck |first=K |authorlink= |author2=Beyaert R |date=January 1999 |title=The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6 |journal=FEBS Lett. |volume=442 |issue=2-3 |pages=147–50 |publisher= |location = NETHERLANDS| issn = 0014-5793| pmid = 9928991 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TRAF2]],<ref name=pmid14743216>{{cite journal |last=Bouwmeester |first=Tewis |authorlink= |coauthors=Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio |date=February 2004 |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue=2 |pages=97–105 |publisher= |location = England| issn = 1465-7392| pmid = 14743216 |doi = 10.1038/ncb1086 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid8702708>{{cite journal |doi=10.1074/jbc.271.33.19935 |last=Takeuchi |first=M |authorlink= |author2=Rothe M |author3=Goeddel D V |date=August 1996 |title=Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins |journal=J. Biol. Chem. |volume=271 |issue=33 |pages=19935–42 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8702708 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RANK]]<ref name=pmid9852070>{{cite journal |doi=10.1074/jbc.273.51.34120 |last=Galibert |first=L |authorlink= |author2=Tometsko M E |author3=Anderson D M |author4=Cosman D |author5=Dougall W C |date=Dec 1998 |title=The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily |journal=J. Biol. Chem. |volume=273 |issue=51 |pages=34120–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9852070 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10025951>{{cite journal |doi=10.1016/S0014-5793(98)01731-1 |last=Kim |first=H H |authorlink= |author2=Lee D E |author3=Shin J N |author4=Lee Y S |author5=Jeon Y M |author6=Chung C H |author7=Ni J |author8=Kwon B S |author9=Lee Z H |date=January 1999 |title=Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase |journal=FEBS Lett. |volume=443 |issue=3 |pages=297–302 |publisher= |location = NETHERLANDS| issn = 0014-5793| pmid = 10025951 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[TRAF interacting protein]].<ref name=pmid9104814>{{cite journal |doi=10.1084/jem.185.7.1275 |last=Lee |first=S Y |authorlink= |author2=Lee S Y |author3=Choi Y |date=April 1997 |title=TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation |journal=J. Exp. Med. |volume=185 |issue=7 |pages=1275–85 |publisher= |location = UNITED STATES| issn = 0022-1007| pmid = 9104814 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2196258 }}</ref>

==References==

==Further reading==

{{PBB_Further_reading

| citations =

*{{cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389–400 |year= 2001 |pmid= 11384837 |doi=10.1016/S0898-6568(01)00160-7 }}

*{{cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788 }}

*{{cite journal | author=Hu HM, O'Rourke K, Boguski MS, Dixit VM |title=A novel RING finger protein interacts with the cytoplasmic domain of CD40. |journal=J. Biol. Chem. |volume=269 |issue= 48 |pages= 30069–72 |year= 1994 |pmid= 7527023 |doi= }}

*{{cite journal | author=Mosialos G, Birkenbach M, Yalamanchili R, et al. |title=The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. |journal=Cell |volume=80 |issue= 3 |pages= 389–99 |year= 1995 |pmid= 7859281 |doi=10.1016/0092-8674(95)90489-1 }}

*{{cite journal | author=Hsu H, Shu HB, Pan MG, Goeddel DV |title=TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. |journal=Cell |volume=84 |issue= 2 |pages= 299–308 |year= 1996 |pmid= 8565075 |doi=10.1016/S0092-8674(00)80984-8 }}

*{{cite journal | author=Hsu H, Huang J, Shu HB, et al. |title=TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. |journal=Immunity |volume=4 |issue= 4 |pages= 387–96 |year= 1996 |pmid= 8612133 |doi=10.1016/S1074-7613(00)80252-6 }}

*{{cite journal | author=Lee SY, Park CG, Choi Y |title=T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. |journal=J. Exp. Med. |volume=183 |issue= 2 |pages= 669–74 |year= 1996 |pmid= 8627180 |doi=10.1084/jem.183.2.669 | pmc=2192463 }}

*{{cite journal | author=Gedrich RW, Gilfillan MC, Duckett CS, et al. |title=CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 12852–8 |year= 1996 |pmid= 8662842 |doi=10.1074/jbc.271.22.12852 }}

*{{cite journal | author=Song HY, Rothe M, Goeddel DV |title=The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6721–5 |year= 1996 |pmid= 8692885 |doi=10.1073/pnas.93.13.6721 | pmc=39093 }}

*{{cite journal | author=Takeuchi M, Rothe M, Goeddel DV |title=Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 19935–42 |year= 1996 |pmid= 8702708 |doi=10.1074/jbc.271.33.19935 }}

*{{cite journal | author=Rothe M, Xiong J, Shu HB, et al. |title=I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8241–6 |year= 1996 |pmid= 8710854 |doi=10.1073/pnas.93.16.8241 | pmc=38654 }}

*{{cite journal | author=Shu HB, Takeuchi M, Goeddel DV |title=The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13973–8 |year= 1997 |pmid= 8943045 |doi=10.1073/pnas.93.24.13973 | pmc=19479 }}

*{{cite journal | author=Ansieau S, Scheffrahn I, Mosialos G, et al. |title=Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 14053–8 |year= 1997 |pmid= 8943059 |doi=10.1073/pnas.93.24.14053 | pmc=19493 }}{{Retracted paper}}

*{{cite journal | author=Lee SY, Lee SY, Choi Y |title=TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. |journal=J. Exp. Med. |volume=185 |issue= 7 |pages= 1275–85 |year= 1997 |pmid= 9104814 |doi=10.1084/jem.185.7.1275 | pmc=2196258 }}

*{{cite journal | author=Marsters SA, Ayres TM, Skubatch M, et al. |title=Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14029–32 |year= 1997 |pmid= 9162022 |doi=10.1074/jbc.272.22.14029 }}

*{{cite journal | author=Boucher LM, Marengère LE, Lu Y, et al. |title=Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 592–600 |year= 1997 |pmid= 9168896 |doi= 10.1006/bbrc.1997.6509 }}

*{{cite journal | author=Shu HB, Halpin DR, Goeddel DV |title=Casper is an FADD- and caspase-related inducer of apoptosis. |journal=Immunity |volume=6 |issue= 6 |pages= 751–63 |year= 1997 |pmid= 9208847 |doi=10.1016/S1074-7613(00)80450-1 }}

*{{cite journal | author=Song HY, Régnier CH, Kirschning CJ, et al. |title=Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9792–6 |year= 1997 |pmid= 9275204 |doi=10.1073/pnas.94.18.9792 | pmc=23270 }}

*{{cite journal | author=Siemienski K, Peters N, Scheurich P, Wajant H |title=Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33-34. |journal=Gene |volume=195 |issue= 1 |pages= 35–9 |year= 1997 |pmid= 9300817 |doi=10.1016/S0378-1119(97)00147-9 }}

}}

<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->

{{PBB_Controls

| update_page = yes

| require_manual_inspection = no

| update_protein_box = yes

| update_summary = yes

| update_citations = yes

}}