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'''TBR5''' is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.<ref>{{Cite journal | last1 = Galardi | first1 = S.| last2 = Fatica | first2 = A.| last3 = Bachi | first3 = A.| last4 = Scaloni | first4 = A.| last5 = Presutti | first5 = C.| last6 = Bozzoni | first6 = I.| doi = 10.1128/MCB.22.19.6663-6668.2002 | title = Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro | journal = [[Molecular and Cellular Biology]]| volume = 22 | issue = 19 | pages = 6663–6668 | date=October 2002 | pmid = 12215523| pmc = 134041}}</ref><ref>{{Cite journal| last = Dunbar | first = DA |author2=Wormsley S |author3=Lowe TM |author4=Baserga SJ | year = 2000 | title = Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA | journal = J Biol Chem | volume = 275 | pages = 14767–14776 | pmid = 10747997 | doi = 10.1074/jbc.M001180200 | issue = 19}}</ref> |
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'''TBR5''' is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.<ref>{{Cite journal | last1 = Galardi | first1 = S.| last2 = Fatica | first2 = A.| last3 = Bachi | first3 = A.| last4 = Scaloni | first4 = A.| last5 = Presutti | first5 = C.| last6 = Bozzoni | first6 = I.| doi = 10.1128/MCB.22.19.6663-6668.2002 | title = Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro | journal = [[Molecular and Cellular Biology]]| volume = 22 | issue = 19 | pages = 6663–6668 | date=October 2002 | pmid = 12215523| pmc = 134041}}</ref><ref>{{Cite journal| last = Dunbar | first = DA |author2=Wormsley S |author3=Lowe TM |author4=Baserga SJ | year = 2000 | title = Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA | journal = J Biol Chem | volume = 275 | pages = 14767–14776 | pmid = 10747997 | doi = 10.1074/jbc.M001180200 | issue = 19}}</ref> |
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Together with [[Small nucleolar RNA TBR7|TBR7]] and [[Small nucleolar RNA TBR17|TBR17]] it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).<ref>{{Cite journal|last=Roberts|first=T. G.|last2=Sturm|first2=N. R.|last3=Yee|first3=B. K.|last4=Yu|first4=M. C.|last5=Hartshorne|first5=T.|last6=Agabian|first6=N.|last7=Campbell|first7=D. A.|date=August 1998|title=Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans|url=https://www.ncbi.nlm.nih.gov/pubmed/9671450|journal=Molecular and Cellular Biology|volume=18|issue=8|pages=4409–4417|issn=0270-7306|pmid=9671450|doi=10.1128/mcb.18.8.4409|pmc=109026}}</ref> The cluster genes are produced as polycistronic RNA.<ref>{{Cite journal|last=Dunbar|first=D. A.|last2=Chen|first2=A. A.|last3=Wormsley|first3=S.|last4=Baserga|first4=S. J.|date=2000-08-01|title=The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA|url=https://www.ncbi.nlm.nih.gov/pubmed/10908346|journal=Nucleic Acids Research|volume=28|issue=15|pages=2855–2861|issn=1362-4962|pmid=10908346|doi=10.1093/nar/28.15.2855|pmc=102681}}</ref> |
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Together with [[Small nucleolar RNA TBR7|TBR7]] and [[Small nucleolar RNA TBR17|TBR17]] it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).<ref>{{Cite journal|last=Roberts|first=T. G.|last2=Sturm|first2=N. R.|last3=Yee|first3=B. K.|last4=Yu|first4=M. C.|last5=Hartshorne|first5=T.|last6=Agabian|first6=N.|last7=Campbell|first7=D. A.|date=August 1998|title=Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans|journal=Molecular and Cellular Biology|volume=18|issue=8|pages=4409–4417|issn=0270-7306|pmid=9671450|doi=10.1128/mcb.18.8.4409|pmc=109026}}</ref> The cluster genes are produced as polycistronic RNA.<ref>{{Cite journal|last=Dunbar|first=D. A.|last2=Chen|first2=A. A.|last3=Wormsley|first3=S.|last4=Baserga|first4=S. J.|date=2000-08-01|title=The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA|journal=Nucleic Acids Research|volume=28|issue=15|pages=2855–2861|issn=1362-4962|pmid=10908346|doi=10.1093/nar/28.15.2855|pmc=102681}}</ref> |
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== See also == |
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== See also == |
Revision as of 15:16, 26 June 2018
TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]
Together with TBR7 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).[3] The cluster genes are produced as polycistronic RNA.[4]
See also
Small nucleolar RNA TBR2
References
- ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ^ Dunbar, DA; Wormsley S; Lowe TM; Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J Biol Chem. 275 (19): 14767–14776. doi:10.1074/jbc.M001180200. PMID 10747997.
{{cite journal}}
: CS1 maint: unflagged free DOI (link)
- ^ Roberts, T. G.; Sturm, N. R.; Yee, B. K.; Yu, M. C.; Hartshorne, T.; Agabian, N.; Campbell, D. A. (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–4417. doi:10.1128/mcb.18.8.4409. ISSN 0270-7306. PMC 109026. PMID 9671450.
- ^ Dunbar, D. A.; Chen, A. A.; Wormsley, S.; Baserga, S. J. (2000-08-01). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–2861. doi:10.1093/nar/28.15.2855. ISSN 1362-4962. PMC 102681. PMID 10908346.
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