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{{Technical|date=March 2010}} |
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{{Technical|date=March 2010}} |
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{{Infobox rfam |
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| Name = Small nucleolar RNA TBR5 |
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| image = RF00292.jpg |
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| width = |
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| caption = Predicted [[secondary structure]] and [[sequence conservation]] of snoTBR5 |
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| Symbol = snoTBR5 |
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| AltSymbols = |
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| Rfam = RF00292 |
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| miRBase = |
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| miRBase_family = |
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| RNA_type = [[Gene]]; [[Small nuclear RNA|snRNA]]; [[Small nucleolar RNA|snoRNA]]; CD-box |
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| Tax_domain = [[Eukaryota]] |
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| GO = {{GO|0006396}} {{GO|0005730}} |
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| SO = {{SO|0000593}} |
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In [[molecular biology]], '''TBR5''' is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.<ref>{{cite journal | vauthors = Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6663–8 | date = October 2002 | pmid = 12215523 | pmc = 134041 | doi = 10.1128/MCB.22.19.6663-6668.2002 }}</ref><ref>{{cite journal | vauthors = Dunbar DA, Wormsley S, Lowe TM, Baserga SJ | title = Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA | journal = The Journal of Biological Chemistry | volume = 275 | issue = 19 | pages = 14767–76 | date = May 2000 | pmid = 10747997 | doi = 10.1074/jbc.M001180200 | doi-access = free }}</ref> |
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{{Rfam_box|acc=RF00292| description=Small nucleolar RNA TBR5 |abbreviation=snoTBR5 |avg_length=84.40 |avg_identity=91.00 |type=Gene; snRNA; snoRNA; CD-box; |se=Moxon SJ, INFERNAL |ss=Predicted; PFOLD; Moxon SJ, Daub J |release=10.0}} |
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Together with [[Small nucleolar RNA TBR7|TBR7]] and [[Small nucleolar RNA TBR17|TBR17]] it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).<ref>{{cite journal | vauthors = Roberts TG, Sturm NR, Yee BK, Yu MC, Hartshorne T, Agabian N, Campbell DA | title = Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans | journal = Molecular and Cellular Biology | volume = 18 | issue = 8 | pages = 4409–17 | date = August 1998 | pmid = 9671450 | pmc = 109026 | doi = 10.1128/mcb.18.8.4409 }}</ref> The cluster genes are produced as polycistronic RNA.<ref>{{cite journal | vauthors = Dunbar DA, Chen AA, Wormsley S, Baserga SJ | title = The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA | journal = Nucleic Acids Research | volume = 28 | issue = 15 | pages = 2855–61 | date = August 2000 | pmid = 10908346 | pmc = 102681 | doi = 10.1093/nar/28.15.2855 }}</ref> |
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'''TBR5''' is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1,2]. |
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==References== |
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== See also == |
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[[Small nucleolar RNA TBR2]] |
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== References == |
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{{Reflist|1}} |
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{{Reflist|1}} |
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* [1] {{Cite journal| last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002 | issue = 19 | pmc = 134041}} |
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* [2] {{Cite journal| last = Dunbar | first = DA | coauthors = Wormsley S, Lowe TM, Baserga SJ | year = 2000 | title = Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA | journal = J Biol Chem | volume = 275 | pages = 14767–14776 | pmid = 10747997 | doi = 10.1074/jbc.M001180200 | issue = 19}} |
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==External links== |
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== External links == |
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* {{Rfam|id=RF00292|name=Small nucleolar RNA TBR5}} |
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* {{Rfam|id=RF00292|name=Small nucleolar RNA TBR5}} |
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{{Small nucleolar RNA}} |
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{{DEFAULTSORT:Small Nucleolar Rna Tbr5}} |
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{{DEFAULTSORT:Small Nucleolar Rna Tbr5}} |
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[[Category:Small nuclear RNA]] |
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[[Category:Small nuclear RNA]] |
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{{Molecular-cell-biology-stub}} |
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{{Molecular-cell-biology-stub}} |
In molecular biology, TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]
Together with TBR7 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).[3] The cluster genes are produced as polycistronic RNA.[4]
Small nucleolar RNA TBR2
- ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ^ Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (May 2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". The Journal of Biological Chemistry. 275 (19): 14767–76. doi:10.1074/jbc.M001180200. PMID 10747997.
- ^ Roberts TG, Sturm NR, Yee BK, Yu MC, Hartshorne T, Agabian N, Campbell DA (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–17. doi:10.1128/mcb.18.8.4409. PMC 109026. PMID 9671450.
- ^ Dunbar DA, Chen AA, Wormsley S, Baserga SJ (August 2000). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–61. doi:10.1093/nar/28.15.2855. PMC 102681. PMID 10908346.
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