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'''TBR5''' is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.<ref>{{Cite journal | last1 = Galardi | first1 = S.| last2 = Fatica | first2 = A.| last3 = Bachi | first3 = A.| last4 = Scaloni | first4 = A.| last5 = Presutti | first5 = C.| last6 = Bozzoni | first6 = I.| doi = 10.1128/MCB.22.19.6663-6668.2002 | title = Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro | journal = [[Molecular and Cellular Biology]]| volume = 22 | issue = 19 | pages = 6663–6668 | date=October 2002 | pmid = 12215523| pmc = 134041}}</ref><ref>{{Cite journal| last = Dunbar | first = DA |author2=Wormsley S |author3=Lowe TM |author4=Baserga SJ | year = 2000 | title = Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA | journal = J Biol Chem | volume = 275 | pages = 14767&ndash;14776 | pmid = 10747997 | doi = 10.1074/jbc.M001180200 | issue = 19}}</ref>
In [[molecular biology]], '''TBR5''' is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.<ref>{{cite journal | vauthors = Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6663–8 | date = October 2002 | pmid = 12215523 | pmc = 134041 | doi = 10.1128/MCB.22.19.6663-6668.2002 }}</ref><ref>{{cite journal | vauthors = Dunbar DA, Wormsley S, Lowe TM, Baserga SJ | title = Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA | journal = The Journal of Biological Chemistry | volume = 275 | issue = 19 | pages = 14767–76 | date = May 2000 | pmid = 10747997 | doi = 10.1074/jbc.M001180200 | doi-access = free }}</ref>


Together with [[Small nucleolar RNA TBR7|TBR7]] and [[Small nucleolar RNA TBR17|TBR17]] it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).<ref>{{Cite journal|last=Roberts|first=T. G.|last2=Sturm|first2=N. R.|last3=Yee|first3=B. K.|last4=Yu|first4=M. C.|last5=Hartshorne|first5=T.|last6=Agabian|first6=N.|last7=Campbell|first7=D. A.|date=August 1998|title=Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans|url=https://www.ncbi.nlm.nih.gov/pubmed/9671450|journal=Molecular and Cellular Biology|volume=18|issue=8|pages=4409–4417|issn=0270-7306|pmid=9671450}}</ref> The cluster genes are produced as polycistronic RNA.<ref>{{Cite journal|last=Dunbar|first=D. A.|last2=Chen|first2=A. A.|last3=Wormsley|first3=S.|last4=Baserga|first4=S. J.|date=2000-08-01|title=The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA|url=https://www.ncbi.nlm.nih.gov/pubmed/10908346|journal=Nucleic Acids Research|volume=28|issue=15|pages=2855–2861|issn=1362-4962|pmid=10908346}}</ref>
Together with [[Small nucleolar RNA TBR7|TBR7]] and [[Small nucleolar RNA TBR17|TBR17]] it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).<ref>{{cite journal | vauthors = Roberts TG, Sturm NR, Yee BK, Yu MC, Hartshorne T, Agabian N, Campbell DA | title = Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans | journal = Molecular and Cellular Biology | volume = 18 | issue = 8 | pages = 4409–17 | date = August 1998 | pmid = 9671450 | pmc = 109026 | doi = 10.1128/mcb.18.8.4409 }}</ref> The cluster genes are produced as polycistronic RNA.<ref>{{cite journal | vauthors = Dunbar DA, Chen AA, Wormsley S, Baserga SJ | title = The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA | journal = Nucleic Acids Research | volume = 28 | issue = 15 | pages = 2855–61 | date = August 2000 | pmid = 10908346 | pmc = 102681 | doi = 10.1093/nar/28.15.2855 }}</ref>

⚫
== See also ==


⚫
==== See also ====
[[Small nucleolar RNA TBR2]]
[[Small nucleolar RNA TBR2]]


==References==
== References ==
{{Reflist|1}}
{{Reflist|1}}


==External links==
== External links ==
* {{Rfam|id=RF00292|name=Small nucleolar RNA TBR5}}
* {{Rfam|id=RF00292|name=Small nucleolar RNA TBR5}}


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{{DEFAULTSORT:Small Nucleolar Rna Tbr5}}
{{DEFAULTSORT:Small Nucleolar Rna Tbr5}}
[[Category:Small nuclear RNA]]
[[Category:Small nuclear RNA]]



{{Molecular-cell-biology-stub}}
{{Molecular-cell-biology-stub}}

Latest revision as of 16:01, 27 October 2021

Small nucleolar RNA TBR5
Predicted secondary structure and sequence conservation of snoTBR5
Identifiers
SymbolsnoTBR5
RfamRF00292
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In molecular biology, TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

Together with TBR7 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).[3] The cluster genes are produced as polycistronic RNA.[4]

See also[edit]

Small nucleolar RNA TBR2

References[edit]

  1. ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ^ Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (May 2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". The Journal of Biological Chemistry. 275 (19): 14767–76. doi:10.1074/jbc.M001180200. PMID 10747997.
  3. ^ Roberts TG, Sturm NR, Yee BK, Yu MC, Hartshorne T, Agabian N, Campbell DA (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–17. doi:10.1128/mcb.18.8.4409. PMC 109026. PMID 9671450.
  4. ^ Dunbar DA, Chen AA, Wormsley S, Baserga SJ (August 2000). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–61. doi:10.1093/nar/28.15.2855. PMC 102681. PMID 10908346.

External links[edit]


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