www.fgks.org   »   [go: up one dir, main page]
Jump to content

Small nucleolar RNA SNORD62: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
{{cite doi}} to share citation
m use template for linking using AWB
Line 9: Line 9:
| miRBase =
| miRBase =
| miRBase_family =
| miRBase_family =
| RNA_type = [[Gene]]; [[Small_nuclear_RNA | snRNA]]; [[Small_nucleolar_RNA | snoRNA]]; CD-box
| RNA_type = [[Gene]]; [[Small nuclear RNA|snRNA]]; [[Small nucleolar RNA|snoRNA]]; CD-box
| Tax_domain = [[Eukaryota]]
| Tax_domain = [[Eukaryota]]
| GO = {{GO|0006396}} {{GO|0005730}}
| GO = {{GO|0006396}} {{GO|0005730}}
Line 27: Line 27:
'''snoRNA U62''' (also known as '''SNORD62''') is a [[non-coding RNA]] (ncRNA) molecule which functions in the modification of other [[small nuclear RNA]]s (snRNAs). This type of modifiying RNA is usually located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA) and also often referred to as a guide RNA.
'''snoRNA U62''' (also known as '''SNORD62''') is a [[non-coding RNA]] (ncRNA) molecule which functions in the modification of other [[small nuclear RNA]]s (snRNAs). This type of modifiying RNA is usually located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA) and also often referred to as a guide RNA.


snoRNA U62 belongs to the [[SnoRNA#C.2FD box|C/D box]] class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-[[methylation]] of substrate RNAs<ref>{{cite doi|10.1128/MCB.22.19.6663-6668.2002}}</ref>.
snoRNA U62 belongs to the [[SnoRNA#C.2FD box|C/D box]] class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-[[methylation]] of substrate RNAs.<ref>{{cite doi|10.1128/MCB.22.19.6663-6668.2002}}</ref>


In the human genome there are two identical copies of snoRNA U62 (called U62A and U62B) both of which are located within the [[introns]] of the same host gene which encodes a hypothetical protein (KIAA0515)<ref name="pmid8962077">{{cite journal | author = Tycowski KT, Smith CM, Shu MD, Steitz JA | title = A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 25 | pages = 14480–5 | year = 1996 | pmid = 8962077 | doi = 10.1073/pnas.93.25.14480 | pmc = 26158 }}</ref>. U62 is predicted to guide the 2'O-ribose methylation of 18S [[ribosomal RNA]] (rRNA) reside A590<ref name=pmid16381836>{{cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158&ndash;D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002 | issue = Database issue | pmc = 1347365}}</ref>.
In the human genome there are two identical copies of snoRNA U62 (called U62A and U62B) both of which are located within the [[introns]] of the same host gene which encodes a hypothetical protein (KIAA0515).<ref name="pmid8962077">{{cite journal | author = Tycowski KT, Smith CM, Shu MD, Steitz JA | title = A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 25 | pages = 14480–5 | year = 1996 | pmid = 8962077 | doi = 10.1073/pnas.93.25.14480 | pmc = 26158 }}</ref> U62 is predicted to guide the 2'O-ribose methylation of 18S [[ribosomal RNA]] (rRNA) reside A590.<ref name=pmid16381836>{{cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158&ndash;D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002 | issue = Database issue | pmc = 1347365}}</ref>


==References==
==References==
Line 36: Line 36:


==External links==
==External links==

* {{Rfam|id=RF00153|name=Small nucleolar RNA SNORD62}}
* {{Rfam|id=RF00153|name=Small nucleolar RNA SNORD62}}
* {{snoRNABase|id=U62|name=SNORD62}}
* [http://www-snorna.biotoul.fr/plus.php?id=U62 snoRNABase entry for SNORD62]


{{Small nucleolar RNA}}
{{Small nucleolar RNA}}

[[Category:Small nuclear RNA]]
[[Category:Small nuclear RNA]]


{{molecular-cell-biology-stub}}
{{molecular-cell-biology-stub}}

Revision as of 22:13, 27 July 2012

Small nucleolar RNA SNORD62
Predicted secondary structure and sequence conservation of SNORD62
Identifiers
SymbolSNORD62
Alt. SymbolsU62
RfamRF00153
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

snoRNA U62 (also known as SNORD62) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U62 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

In the human genome there are two identical copies of snoRNA U62 (called U62A and U62B) both of which are located within the introns of the same host gene which encodes a hypothetical protein (KIAA0515).[2] U62 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) reside A590.[3]

References

  1. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1128/MCB.22.19.6663-6668.2002, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1128/MCB.22.19.6663-6668.2002 instead.
  2. ^ Tycowski KT, Smith CM, Shu MD, Steitz JA (1996). "A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14480–5. doi:10.1073/pnas.93.25.14480. PMC 26158. PMID 8962077.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Lestrade, L (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34 (Database issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)



Stub icon

This molecular or cell biology article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Small_nucleolar_RNA_SNORD62&oldid=504501980"