Small nucleolar RNA SNORA40: Difference between revisions

In [[molecular biology]], the '''small nucleolar RNA ACA40''' belongs to the [[snoRNA|H/ACA family of snoRNAs]] and guides the [[pseudouridine|pseudouridylation]] of [[rRNA|28S rRNA]] subunit at position U4565. snoRNA ACA40 was discovered using large-scale [[Molecular cloning|cloning]] by Kiss et al. (2004)<ref name=pmid15199136>{{Cite journal | last1 = Kiss | first1 = Arnold M. | last2 = Jády | first2 = Beáta E. | last3 = Bertrand | first3 = Edouard | last4 = Kiss | first4 = Tamás | title = Human Box H/ACA Pseudouridylation Guide RNA Machinery | doi = 10.1128/MCB.24.13.5797-5807.2004 | journal = [[Molecular and Cellular Biology]] | volume = 24 | issue = 13 | pages = 5797–5807 | pmc = 480876 | year = 2004 | pmid = 15199136}}</ref> from a [[HeLa]] cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the [[Pseudouridine|pseudouridylation]] of residues [[rRNA|28S rRNA]] U4546 and [[rRNA|18S rRNA]] 1174.<ref name=pmid15199136/><ref name="pmid16373490">{{cite journal |vauthors=Schattner P, Barberan-Soler S, Lowe TM | title = A computational screen for mammalian pseudouridylation guide H/ACA RNAs | journal = RNA | volume = 12 | issue = 1 | pages = 15–25 | year = 2006 | pmid = 16373490 | doi = 10.1261/rna.2210406 | pmc = 1370881 }}</ref> The pseudouridylation of these residues was reported by Ofengand and Bakin (1997)<ref>{{cite journal | last = Ofengand | first = J |author2=Bakin A | year = 1997 | title = Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts | journal = J Mol Biol | volume = 266 | pages = 246&ndash;268 | pmid = 9047361 | doi = 10.1006/jmbi.1996.0737 | issue = 2}}</ref> and Maden (1990).<ref name="pmid2247610">{{cite journal | author = Maden BE | title = The numerous modified nucleotides in eukaryotic ribosomal RNA | journal = Prog. Nucleic Acid Res. Mol. Biol. | series = Progress in Nucleic Acid Research and Molecular Biology | volume = 39 | pages = 241–303 | year = 1990 | pmid = 2247610 | doi = 10.1016/S0079-6603(08)60629-7 | isbn = 9780125400398 }}</ref> [[Small nucleolar RNA SNORA1|ACA1]], [[Small nucleolar RNA SNORA1|ACA8]], [[Small nucleolar RNA SNORA18|ACA18]], [[Small nucleolar RNA SNORA25|ACA25]], [[Small nucleolar RNA SNORA32|ACA32]] and [[Small nucleolar RNA SNORA1|ACA40]] and the C/D box snoRNAs mgh28S-2409 and mgh28S-2411 share the same host gene (MGC5306).