CST6 (gene): Difference between revisions

'''Cystatin-M''' is a [[protein]] that in humans is encoded by the ''CST6'' [[gene]].<ref name="pmid9154125">{{cite journal | author = Stenman G, Astrom AK, Roijer E, Sotiropoulou G, Zhang M, Sager R | title = Assignment of a novel cysteine proteinase inhibitor (CST6) to 11q13 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 76 | issue = 1-2 | pages = 45–6 |date=Jun 1997 | pmid = 9154125 | pmc = | doi =10.1159/000134512 }}</ref><ref name="pmid9099741">{{cite journal | author = Ni J, Abrahamson M, Zhang M, Fernandez MA, Grubb A, Su J, Yu GL, Li Y, Parmelee D, Xing L, Coleman TA, Gentz S, Thotakura R, Nguyen N, Hesselberg M, Gentz R | title = Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins | journal = J Biol Chem | volume = 272 | issue = 16 | pages = 10853–8 |date=May 1997 | pmid = 9099741 | pmc = | doi =10.1074/jbc.272.16.10853 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CST6 cystatin E/M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1474| accessdate = }}</ref>

*{{cite journal | author=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution. |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5–12 |year= 1997 |pmid= 9007972 |doi=10.1002/pro.5560060102 | pmc=2143511 }}

*{{cite journal | author=Barka T, Asbell PA, van der Noen H, Prasad A |title=Cystatins in human tear fluid. |journal=Curr. Eye Res. |volume=10 |issue= 1 |pages= 25–34 |year= 1991 |pmid= 2029847 |doi=10.3109/02713689109007608 }}

*{{cite journal | author=Saitoh E, Isemura S, Sanada K |title=Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. | series=369 |journal=Biol. Chem. Hoppe-Seyler |volume=Suppl |issue= |pages= 191–7 |year= 1989 |pmid= 3202964 |doi= |display-authors=etal}}

*{{cite journal | author=Thiesse M, Millar SJ, Dickinson DP |title=The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20. |journal=DNA Cell Biol. |volume=13 |issue= 2 |pages= 97–116 |year= 1994 |pmid= 8179826 |doi=10.1089/dna.1994.13.97 }}

*{{cite journal | author=Sotiropoulou G, Anisowicz A, Sager R |title=Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 903–10 |year= 1997 |pmid= 8995380 |doi=10.1074/jbc.272.2.903 }}

*{{cite journal | author=Zeeuwen PL, Van Vlijmen-Willems IM, Jansen BJ |title=Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase. |journal=J. Invest. Dermatol. |volume=116 |issue= 5 |pages= 693–701 |year= 2001 |pmid= 11348457 |doi= 10.1046/j.1523-1747.2001.01309.x |display-authors=etal}}

*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}

*{{cite journal | author=Zeeuwen PL, Dale BA, de Jongh GJ |title=The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis. |journal=J. Invest. Dermatol. |volume=121 |issue= 1 |pages= 65–8 |year= 2003 |pmid= 12839564 |doi= 10.1046/j.1523-1747.2003.12312.x |display-authors=etal}}

*{{cite journal | author=Shridhar R, Zhang J, Song J |title=Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells. |journal=Oncogene |volume=23 |issue= 12 |pages= 2206–15 |year= 2004 |pmid= 14676833 |doi= 10.1038/sj.onc.1207340 |display-authors=etal}}

*{{cite journal | author=Zhang J, Shridhar R, Dai Q |title=Cystatin m: a novel candidate tumor suppressor gene for breast cancer. |journal=Cancer Res. |volume=64 |issue= 19 |pages= 6957–64 |year= 2004 |pmid= 15466187 |doi= 10.1158/0008-5472.CAN-04-0819 |display-authors=etal}}

*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}

*{{cite journal | author=Song J, Jie C, Polk P |title=The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin. |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 1 |pages= 175–82 |year= 2006 |pmid= 16356477 |doi= 10.1016/j.bbrc.2005.11.171 |display-authors=etal}}

*{{cite journal | author=Cheng T, Hitomi K, van Vlijmen-Willems IM |title=Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. |journal=J. Biol. Chem. |volume=281 |issue= 23 |pages= 15893–9 |year= 2006 |pmid= 16565075 |doi= 10.1074/jbc.M600694200 |display-authors=etal}}

*{{cite journal | author=Ai L, Kim WJ, Kim TY |title=Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression. |journal=Cancer Res. |volume=66 |issue= 16 |pages= 7899–909 |year= 2007 |pmid= 16912163 |doi= 10.1158/0008-5472.CAN-06-0576 |display-authors=etal}}

*{{cite journal | author=Rivenbark AG, Jones WD, Coleman WB |title=DNA methylation-dependent silencing of CST6 in human breast cancer cell lines. |journal=Lab. Invest. |volume=86 |issue= 12 |pages= 1233–42 |year= 2007 |pmid= 17043665 |doi= 10.1038/labinvest.3700485 }}

*{{cite journal | author=Schagdarsurengin U, Pfeifer GP, Dammann R |title=Frequent epigenetic inactivation of cystatin M in breast carcinoma. |journal=Oncogene |volume=26 |issue= 21 |pages= 3089–94 |year= 2007 |pmid= 17099723 |doi= 10.1038/sj.onc.1210107 }}

*{{cite journal | author=Rivenbark AG, Livasy CA, Boyd CE |title=Methylation-dependent silencing of CST6 in primary human breast tumors and metastatic lesions. |journal=Exp. Mol. Pathol. |volume=83 |issue= 2 |pages= 188–97 |year= 2007 |pmid= 17540367 |doi= 10.1016/j.yexmp.2007.03.008 | pmc=2693953 |display-authors=etal}}

{{gene-11-stub}}