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Long-term prognosis after treatment for T1 carcinoma of laterally spreading tumors: a multicenter retrospective study

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Long-term prognosis of T1 laterally spreading tumors (LSTs) after treatment have not been clarified. This study compared clinicopathological characteristics and long-term prognosis of T1 LSTs.

Methods

We retrospectively assessed 169 patients with 169 T1 LSTs between January 1992 and December 2008 by ten hospitals. Patients who did not meet the Japanese Society for Cancer of the Colon and Rectum (JSCCR) 2016 guidelines for the treatment of colorectal carcinoma (CRC) criteria were defined as non-endoscopically curable. The number of non-endoscopically curable patients with LST-granular/ nodular mixed (LST-G-M) was 61, that with LST-non-granular/ flat elevated (LST-NG-FE) was 23, and that with LST-non-granular/ pseudo depressed (LST-NG-PD) was 23. Clinicopathological variables and long-term prognosis were analyzed.

Results

For overall patients, tumor size, number of non-endoscopically curable cases, and rate of submucosal invasion depth ≥ 1000 μm for the LST-G-M group were significantly higher than those in the other groups. For non-endoscopically curable patients, the tumor size for those with LST-G-M was significantly larger than those in the other groups. The rate of submucosal invasion width ≥ 4000 μm and type B/C muscularis mucosae with LST-G-M was higher than that with LST-NG-FE. All recurrences occurred in non-endoscopically curable patients with LST-G-M. Five-year overall and disease-free survivals for non-endoscopically curable patients with LST-G-M were significantly shorter than those for patients with non-endoscopically curable LST-NG-FE and PD.

Conclusions

Our data supported adequacy of the JSCCR guidelines for the treatment of CRC criteria for endoscopically curable patients after T1 LSTs treatment. Patients with T1 LST-G-M should be followed up more carefully.

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Author information

Authors and Affiliations

  1. Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Ken Yamashita, Shiro Oka & Kazuaki Chayama

  2. Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan

    Shinji Tanaka

  3. Department of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan

    Shinji Nagata

  4. Department of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan

    Toshio Kuwai

  5. Department of Gastroenterology, JA Hiroshima General Hospital, Hiroshima, Japan

    Akira Furudoi

  6. Department of Internal Medicine, Hiroshima Memorial Hospital, Hiroshima, Japan

    Tadamasa Tamura

  7. Department of Internal Medicine, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan

    Masaki Kunihiro

  8. Department of Gastroenterology, Chugoku Rosai Hospital, Kure, Japan

    Hideharu Okanobu

  9. Department of Gastroenterology, JA Onomichi General Hospital, Onomichi, Japan

    Koichi Nakadoi

  10. Department of Gastroenterology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan

    Hiroyuki Kanao

  11. Department of Gastroenterology, Shobara Red Cross Hospital, Shobara, Japan

    Makoto Higashiyama

  12. Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan

    Koji Arihiro

  13. Department of Anatomical Pathology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan

    Kazuya Kuraoka

  14. Faculty of Health Sciences, Hiroshima Shudo University, Hiroshima, Japan

    Fumio Shimamoto

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  1. Ken Yamashita
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  2. Shiro Oka
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  3. Shinji Tanaka
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  4. Shinji Nagata
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  5. Toshio Kuwai
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  6. Akira Furudoi
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  7. Tadamasa Tamura
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  9. Hideharu Okanobu
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  10. Koichi Nakadoi
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  11. Hiroyuki Kanao
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  12. Makoto Higashiyama
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  13. Koji Arihiro
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  14. Kazuya Kuraoka
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  15. Fumio Shimamoto
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  16. Kazuaki Chayama
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Corresponding author

Correspondence to Shiro Oka.

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This study was performed in accordance with the ethical standards in the 1964 Declaration of Helsinki and its later amendments.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Yamashita, K., Oka, S., Tanaka, S. et al. Long-term prognosis after treatment for T1 carcinoma of laterally spreading tumors: a multicenter retrospective study. Int J Colorectal Dis 34, 481–490 (2019). https://doi.org/10.1007/s00384-018-3203-7

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  • DOI: https://doi.org/10.1007/s00384-018-3203-7

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