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The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Invited Review for the 90th Anniversary
Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies
Department of Pharmacology, Southern Illinois University School of Medicine">Leonard P Rybak,  Department of Pharmacology, Southern Illinois University School of Medicine">Debashree Mukherjea, Sarvesh Jajoo, Vickram Ramkumar
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Keywords: ototoxicity, cisplatin, cochlea, protection, mechanisms
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2009 Volume 219 Issue 3 Pages 177-186

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Abstract

Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity occur with the use of this agent. This review summarizes recent important clinical and experimental investigations of cisplatin ototoxicity. It also discusses the utility of protective agents employed in patients and in experimental animals. The future strategies for limiting cisplatin ototoxicity will need to avoid interference with the therapeutic effect of cisplatin in order to enhance the quality of life of patients receiving this important anti-tumor agent.

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© 2009 Tohoku University Medical Press
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.

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