Contents
Overview
CTD's chemical vocabulary is a modified subset of descriptors from the “Chemicals and Drugs” category and Supplementary Concept Records from the U.S. National Library of Medicine (NLM) Medical Subject Headings (MeSH®), a hierarchical vocabulary used to index articles for MEDLINE®/PubMed®.[1] In contrast to MeSH at NLM, CTD merged the descriptors and supplementary concepts into a single hierarchy.
The chemical vocabulary is structured as a polyhierarchic tree in which a term may appear as a node in more than one branch. A term may have different descendant terms in each branch in which it appears (although CTD combines all descendants from all branches to reflect how our data is curated, searched, and displayed).
Several branches of the original MeSH vocabulary were excluded from CTD's chemical vocabulary because they are not molecular reagents, environmental chemicals or clinical drugs (e.g., “Nucleic Acids, Nucleotides, and Nucleosides” and “Purines”). Other branches were excluded because they are simply broad chemical classes that do not contain more specific terms (e.g., “Solutions” and “Poisons”).
Top ↑ Basics
Names, Synonyms, CAS Registry Number, etc.
The name of the chemical. It may also have a CAS Type 1 Name, CAS Registry Number, and synonyms; some of the synonyms may have been captured by CTD scientists during literature-based curation, augmenting MeSH's synonym list.
CAS Registry Number is a Registered Trademark of the American Chemical Society.
Definition
A short definition of this chemical (from MeSH scope notes).
Structure
A drawing of the two-dimensional structure of the chemical. Drawings are integrated from ChemIDplus®, an NLM TOXNET® resource.
MeSH® ID
The unique identifier assigned to the chemical by MeSH, linked to the MeSH record for the chemical.
Curator Notes
Comments added by a CTD curator.
Curation Status
Some chemicals do not yet have curated gene interactions and/or disease associations. Click the button to request additional curation for this chemical.
Top Interacting Genes
Specific chemical–gene and protein interactions in vertebrates and invertebrates are being curated from the published literature. This chart provides a view of the ten genes with the most curated interactions for this chemical. The colored bars are linked to corresponding interactions within the interaction report for this chemical (see the Interactions tab).
External Links
Information about this chemical in other resources:
- ChEBI
- A dictionary of molecular entities focused on small chemical compounds.
- ChemIDplus®
- A resource providing access to structure and nomenclature information for the identification of chemical substances cited in NLM® databases.
- MeSH®
- The National Library of Medicine®'s hierarchical controlled vocabulary thesaurus. Components of this vocabulary are used for the CTD chemical and disease vocabularies.
- PubChem
- Provides information on the biological activities of small molecules.
Use Term in Query
Click the Use button to add this term to the Chemical field on the query form.
Top ↑ Hierarchies
Each chemical occurs in at least one location of the hierarchy; many occur in more than one. Each ancestor path of the hierarchy is presented separately, but descendants for all paths are aggregated in a single display to reflect how data in CTD is curated, searched, and displayed.
Nodes are indented to indicate their relative level in the tree. A node marked by the
symbol has descendants in at least one of the
hierarchical paths displayed on the current page. The same term may or may not have descendants, depending on each
particular path in which it appears. Click a term in the ancestor path to move up the tree, or click a descendant
node to move down.
If you arrived at this page from a query form, you may click the Use button to add this term to the Chemical field on the query form.
Top ↑ Footnotes
- [1]
- Lipscomb CE. Medical Subject Headings (MeSH). Bull Med Libr Assoc. 2000 Jul;88(3):265-6. PMID:10928714