Bridged Bicyclo Compounds, Heterocyclic - Diseases

These diseases are associated with Bridged Bicyclo Compounds, Heterocyclic or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

Disease categories [Show chart]

1–50 of 12,693 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Cocaine	Schizophrenia	M	53 genes AKT1 \| APOL2 \| AS3MT \| BDNF \| CAMK2B \| CASP4 \| CCL2 \| CNR1 \| COL3A1 \| CPLX1 \| DRD1 \| DRD2 \| DRD3 \| DRD4 \| FGFR1 \| GABRB2 \| GAD1 \| GAD2 \| GRIK2 \| GRIK5 \| GRIN2B \| GRIN2D \| GRM2 \| GRM3 \| GSK3A \| GSK3B \| HTR2A \| HTR6 \| IL1B \| IL2RA \| IL6 \| IL6R \| KCNB1 \| MAOB \| MET \| MIR137 \| ND4 \| NDUFV2 \| NOS1 \| NR3C1 \| OXTR \| PLCB1 \| PVALB \| RELN \| RGS9 \| SBNO1 \| SHANK3 \| SLC6A3 \| SLC6A4 \| SYN2 \| SYP \| TAC1 \| TNF	64.42	49
2.	Cocaine	Myocardial Ischemia	M	54 genes ADRB1 \| AGT \| AK1 \| ATP1A1 \| BHLHE40 \| BMAL1 \| CALR \| CCL2 \| CCL3 \| CCND1 \| CRP \| CTNNB1 \| CX3CL1 \| CXCL10 \| DNM1L \| DUSP1 \| EDN1 \| EGR2 \| EIF2AK3 \| FEV \| FGF2 \| GCLC \| GSTP1 \| GYG1 \| HSPA1A \| HSPA9 \| ICAM1 \| IL1A \| IL1B \| IL6 \| JAK2 \| JUNB \| KCNJ8 \| KLF4 \| MAPK14 \| NFKBIA \| NOS3 \| NPPA \| NR4A1 \| PEBP1 \| POMC \| PPP2CA \| PRKCE \| PTPRA \| RAB12 \| RYR2 \| SELP \| SOD2 \| TFRC \| TMPO \| TNF \| UGCG \| VCAM1 \| VEGFA	54.45	57
3.	Cocaine	Reperfusion Injury	M	43 genes ADORA2A \| ADORA2B \| AGT \| BCL2 \| CASP3 \| CASP8 \| CAT \| CCL2 \| CCL3 \| CDKN1A \| CHAT \| CXCL8 \| CYBB \| EDN1 \| EFNA5 \| EFNB2 \| EGR1 \| FGF2 \| FOS \| GJB1 \| GPT \| GPX1 \| HSPA1A \| HSPB1 \| ICAM1 \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| MAPK8 \| MIR148B \| MMP9 \| MPO \| NOS3 \| PARP1 \| PTEN \| RELA \| SOD1 \| SOD2 \| STAT3 \| TNF \| XDH	51.49	45
4.	Cocaine	Brain Ischemia	M	34 genes ACE \| BDNF \| CASP3 \| CASP9 \| CAT \| CCL2 \| CCL3 \| CHRM1 \| CXCL10 \| CYCS \| DYNLL1 \| EGR1 \| GPX1 \| HIF1A \| ICAM1 \| IL1A \| IL1B \| IL6 \| JUN \| MAP2K1 \| MAPK1 \| MAPK3 \| MMP9 \| MPO \| NFKB1 \| NFKBIA \| PARP1 \| RELA \| SOD1 \| SOD2 \| STAT3 \| TNF \| TNFRSF1A \| TNFRSF1B	41.65	28
5.	Scopolamine	Alzheimer Disease	M	14 genes ACHE \| APP \| ARC \| BAX \| BCL2 \| BDNF \| CASP3 \| CHRNB2 \| EIF2S1 \| HMOX1 \| IL1B \| MAPT \| PSEN2 \| TNF	33.84	52
6.	Cocaine	Myocardial Reperfusion Injury	M	27 genes ADRB1 \| AGT \| ATP1A1 \| BAX \| CASP3 \| CASP8 \| CASP9 \| CAT \| CCL2 \| COBLL1 \| CYBB \| EDN1 \| HIF1A \| ICAM1 \| MIR137 \| MIR186 \| MIR301B \| MIR337 \| MIR369 \| MIR376A \| MIR500 \| NOS3 \| PHLDA3 \| PTEN \| SELP \| TFRC \| VEGFA	28.99	18
7.	Cocaine	Heart Failure	M	48 genes ACE \| ADRB1 \| AGT \| APCS \| ATP1A3 \| BAMBI \| CAT \| CCL2 \| CCN2 \| CIDEA \| CRP \| CXCL8 \| CYBB \| EDN1 \| EDNRA \| EDNRB \| GRK2 \| GSK3B \| HIF1A \| HSPB1 \| IFNG \| IL1B \| IL6 \| INS \| ITGB1 \| MAP2K1 \| MAPK10 \| NFE2L2 \| NOS3 \| NPPA \| NR3C2 \| PDPK1 \| PEBP1 \| POMC \| PRL \| RAC1 \| ROCK2 \| SNCA \| SOD1 \| SOD2 \| SPHKAP \| STAT3 \| TNF \| TNFRSF1A \| TRP53 \| VEGFA \| VWF \| XDH	28.91	62
8.	Cocaine	Bipolar Disorder	M	31 genes ADCY2 \| BDNF \| BHLHE40 \| CACNA1D \| CD47 \| CPLX1 \| DRD1 \| DRD5 \| GAD1 \| GAD2 \| GRIK2 \| GRIN2A \| GSK3A \| GSK3B \| HDAC5 \| HTR2A \| INS \| NCAN \| NDUFV2 \| NR3C1 \| NTRK2 \| POMC \| PVALB \| RELN \| S100B \| SHANK2 \| SLC5A3 \| SLC6A4 \| TAC1 \| TACR1 \| TENM4	27.98	24
9.	Cocaine	Status Epilepticus	M	31 genes BDNF \| CASP3 \| CASP8 \| CAT \| CCL2 \| CCL3 \| CCR2 \| CNR1 \| CRH \| EIF2AK3 \| EIF2S1 \| FOS \| GAP43 \| GDNF \| GRIA2 \| GRM1 \| GRM5 \| HSPB1 \| JUN \| JUNB \| JUND \| LAMP2 \| NGF \| NOS1 \| NTRK2 \| PTK2B \| SRC \| SSTR1 \| SSTR2 \| TNF \| VEGFA	27.88	45
10.	Cocaine	Substance Withdrawal Syndrome	M	39 genes ADCY8 \| ADORA1 \| ADORA2A \| BDNF \| CCKBR \| CHRM5 \| CHRNA5 \| CHRNB2 \| CNR1 \| CREB1 \| CRH \| CRP \| DRD2 \| FOS \| GNAO1 \| GRIA1 \| GRIA2 \| GRIN2A \| HCRT \| HTR2C \| MAPK1 \| MAPK3 \| MMP9 \| NPTX2 \| NPY \| OPRD1 \| OPRK1 \| PER1 \| PER2 \| PER3 \| POMC \| PRL \| RHOA \| RUNX2 \| SLC6A4 \| SMAD1 \| SMAD5 \| SMURF1 \| TACR1	24.90	119
11.	Atropine	Myocardial Ischemia	M	13 genes CTNNB1 \| EDN1 \| EGR2 \| ICAM1 \| IL1B \| IL6 \| JUNB \| MAPK14 \| NPPA \| POMC \| SOCS3 \| TNF \| VCAM1	23.91	12
12.	Cocaine	Disease Models, Animal	M	41 genes AKT1 \| APP \| BSCL2 \| CACNA1D \| CALY \| CLDN11 \| CNR1 \| CNR2 \| CTNNB1 \| EIF3E \| FAS \| FOS \| GFAP \| GLI2 \| GRIN1 \| IFNG \| IL10 \| IL1B \| KL \| MAPK1 \| MAPK3 \| MAPK8 \| MECP2 \| MET \| MMP9 \| NFE2L2 \| PIM1 \| PRKCG \| RHOA \| ROCK2 \| RPSA \| S100B \| SATB1 \| SLC4A4 \| SNCA \| SOD1 \| STAT3 \| TGFBR1 \| TK1 \| TNF \| TRP53	23.28	50
13.	Scopolamine	Amnesia	M	11 genes APP \| AVP \| CSF2 \| HRH3 \| IL1A \| IL6 \| NGF \| PDYN \| PREP \| SIGMAR1 \| TAC1	23.16	180
14.	Cocaine	Pancreatic Neoplasms	M	27 genes ATM \| ATRX \| BCL2L1 \| CD44 \| CDH1 \| CFLAR \| CNR1 \| CNR2 \| CTNNB1 \| CXCL8 \| EGFR \| FOXP1 \| HIF1A \| KLF5 \| MMP9 \| NFKBIA \| NR4A1 \| NRP1 \| PTEN \| SOD2 \| SSTR1 \| SSTR2 \| STAT3 \| TNF \| TNFRSF10B \| TNFSF10 \| TRP53	22.91	29
15.	Cocaine	Cardiomyopathies	M	34 genes ADCYAP1 \| ADORA2A \| AGT \| AKT1 \| APP \| ATF3 \| CAT \| COX1 \| CYP2C9 \| EDN1 \| FAS \| GRK2 \| HSPD1 \| IL1A \| IL1B \| IL4 \| IL6 \| ITGB1 \| MAPK1 \| MAPK11 \| MAPK14 \| MAPK3 \| NDUFS2 \| NDUFV2 \| PARP1 \| POMC \| PRKCE \| SGCB \| SOD2 \| STAT3 \| TNF \| TNNI3 \| TRP53 \| YWHAH	22.88	43
16.	Cocaine	Acute Coronary Syndrome	M	15 genes CAPZB \| CKB \| CKM \| CRP \| GSN \| GSTP1 \| HSPD1 \| IL6 \| ITGB3 \| LDHB \| MMP9 \| PDIA3 \| SOD2 \| TNF \| TNNI3	21.84	19
17.	Cocaine	HIV Infections	M	23 genes BAG3 \| BAX \| CCL2 \| CCL3 \| CCR2 \| CCR5 \| CDKN1A \| CLIC1 \| EIF3B \| HSP90AA1 \| HSP90AB1 \| HSPA9 \| HSPB1 \| HSPD1 \| IFNG \| IL10 \| IL2 \| IL2RA \| KPNB1 \| NUP88 \| PPIB \| PSME4 \| SIGMAR1	21.83	7
18.	Cocaine	Hypertension	M	63 genes ACE \| ADRB1 \| AGT \| ATP1A1 \| BCL2 \| CAT \| CCL2 \| CCN2 \| COL1A1 \| COL3A1 \| CRP \| CYBA \| CYBB \| CYP1A1 \| DRD2 \| DUSP5 \| EDN1 \| EDNRA \| FNDC5 \| FOS \| GAD1 \| GAL \| GCLC \| GJA5 \| GNRH1 \| GPX1 \| GRK2 \| GSK3B \| GSTP1 \| GUCY1A1 \| HIF1A \| ICAM1 \| IKBKB \| IL1B \| IL6 \| INS \| JUN \| LHB \| MDH1 \| MMP9 \| MYH7 \| NCF1 \| NEDD4L \| NFE2L2 \| NOS3 \| NPPA \| NR3C1 \| POMC \| PPBP \| PRKCD \| PTEN \| REG3G \| RELA \| RGS2 \| SELP \| SLC6A2 \| SOD1 \| SOD2 \| TACR1 \| TH \| TNF \| VCAM1 \| VWF	21.52	269
19.	Cocaine	Myocardial Infarction	M	39 genes ACE \| ADORA1 \| AGT \| ATM \| ATP1A1 \| BAX \| BCL2 \| BCL2L1 \| CASP3 \| CAT \| CKB \| CKM \| CREB1 \| CREM \| DAB2IP \| DDIT3 \| GCLC \| GCLM \| GSK3B \| HSPA5 \| ICAM1 \| IL10 \| IL1B \| IL6 \| ITGB3 \| MFF \| MMP9 \| MYH7 \| NOS3 \| NPPA \| NR3C2 \| PHLDA3 \| PRKCE \| S100B \| SOD1 \| SOD2 \| TNF \| TNNI3 \| TRP53	21.44	172
20.	Cocaine	Heat Stroke	M	11 genes FOS \| IL10 \| IL1A \| IL1B \| IL6 \| JUN \| NFKB1 \| NFKB2 \| REL \| RELA \| TNF	20.78	3
21.	Atropine	Substance Withdrawal Syndrome	M	12 genes CHRM5 \| CHRNB2 \| CREB1 \| CRH \| FOS \| MAPK1 \| MAPK3 \| NOS2 \| OPRL1 \| PNOC \| POMC \| RHOA	19.76	17
22.	Cocaine	Autoimmune Diseases	M	16 genes COL1A1 \| CRYBB2 \| EGR1 \| FAS \| FCGR2B \| HSPA9 \| IFNG \| IL4 \| IL6 \| ITGB6 \| PECAM1 \| PF4 \| SOD2 \| STAT3 \| TGFB2 \| TNFRSF1A	19.41	14
23.	Scopolamine	Learning Disabilities	M	10 genes ACHE \| APP \| BCL2 \| HMOX1 \| HTR1A \| IL1B \| IL1RN \| MAPT \| SIGMAR1 \| SYP	18.42	67
24.	Cocaine	Cardiomyopathy, Dilated	M	17 genes ADRB1 \| ATM \| CTNNB1 \| EGFR \| FAS \| GPX1 \| HDAC6 \| ITGB1 \| MYH6 \| MYH7 \| NPPA \| NR3C2 \| RAC1 \| RAF1 \| SOD2 \| TMPO \| TNNI3	18.17	30
25.	Cocaine	Cardiomegaly	M	28 genes ADRA1B \| AGT \| AKT1 \| BAMBI \| CYP1A1 \| EDN1 \| FGF2 \| FNDC5 \| GLRX3 \| GRK2 \| GSK3B \| GSN \| HIF1A \| IL1B \| MIR384 \| NOS3 \| NPPA \| PLD2 \| PLPP3 \| POMC \| PRKCA \| PRKCB \| PRKCZ \| ROCK2 \| SOD2 \| SRC \| STAT3 \| TNF	17.15	64
26.	Cocaine	Brain Injuries	M	27 genes BDNF \| CCL2 \| CES1 \| CXCL10 \| FGF2 \| FOS \| GABRB3 \| GSK3B \| HSPA1A \| IL10 \| IL1A \| IL1B \| IL2 \| IL6 \| JUN \| MIR132 \| MMP9 \| MPO \| PARP1 \| PPP3CA \| S100B \| SOD2 \| TNF \| TNFRSF14 \| TNFRSF1A \| TNFSF10 \| VEGFA	17.02	22
27.	Cocaine	Neurodevelopmental Disorders	M	15 genes CTNNB1 \| DLG4 \| DNM1 \| EEF1A2 \| FOXP1 \| GABRB2 \| GABRB3 \| GNAO1 \| GRIN2B \| ITPR1 \| KMT2E \| MECP2 \| PTEN \| STXBP1 \| TCF4	16.64	3
28.	Atropine	Myocardial Infarction	M	11 genes BAX \| CASP3 \| CREB1 \| F2 \| ICAM1 \| IL1B \| IL6 \| NOS2 \| NPPA \| TGFB1 \| TNF	16.16	14
29.	Cocaine	Substance-Related Disorders	M	22 genes CHRNA5 \| CNR1 \| DNAH8 \| DRD2 \| FAM184B \| GRIA4 \| GRIK2 \| GRM5 \| GRM7 \| NME7 \| NPY \| OPRD1 \| OPRM1 \| PARVA \| PBX1 \| PLA2R1 \| PRKCE \| SLC6A4 \| SLK \| SYNE1 \| TENM2 \| TIAM2	15.07	22
30.	Cocaine	Nerve Degeneration	M	35 genes ADORA1 \| ADRA1B \| APP \| ATXN3 \| BAX \| BCL2 \| BDNF \| CASP3 \| CD4 \| CD44 \| CDH1 \| CDK5R1 \| CHRNB2 \| CNR1 \| CTNNB1 \| EIF2S1 \| FGF2 \| GRIN2D \| IFNG \| IGF2 \| KCNJ4 \| KCNJ6 \| MAPK1 \| MAPK3 \| NGF \| NOS1 \| SLC18A2 \| SLC1A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TH \| TNF \| XDH	14.96	56
31.	Cocaine	Atrial Fibrillation	M	25 genes ACE \| ATXN1 \| CDKN1A \| EDN1 \| EPHA3 \| GJA5 \| GNB4 \| HERC1 \| HTR4 \| IGF1R \| KCND3 \| MYH6 \| MYH7 \| NOS3 \| NR3C1 \| NUCKS1 \| PKP2 \| PSMB7 \| PTK2 \| SCN10A \| SORL1 \| SPATS2L \| SYNPO2L \| TUBA8 \| VWF	14.33	12
32.	Cocaine	Asthma	M	24 genes ADCY2 \| ADCYAP1R1 \| ALDH2 \| BCL2 \| CAT \| CCL2 \| EDN1 \| GSTP1 \| HTR2A \| ICAM1 \| IL10 \| IL1B \| IL4 \| IL6 \| IL6R \| KIF3A \| MMP9 \| NPY \| PARP1 \| PPP2CA \| PTEN \| SOD1 \| TNF \| VEGFA	14.16	37
33.	Scopolamine	Disease Models, Animal	M	10 genes APP \| CACNA1D \| FOS \| GFAP \| IFNG \| IL10 \| IL1B \| MAPT \| NFE2L2 \| TNF	14.08	17
34.	Cocaine	Abortion, Spontaneous	M	16 genes COL1A1 \| CXCL10 \| CYP1A1 \| FLRT3 \| IGF2 \| IL16 \| IL1B \| IL6 \| INHA \| ITGB6 \| JAK2 \| MAP2 \| PGF \| TFRC \| TGFBR1 \| TNFSF10	12.65	6
35.	Cocaine	Atherosclerosis	M	21 genes AGT \| CCL2 \| CCL3 \| CNR2 \| CRP \| CYBA \| HSPA1B \| ICAM1 \| IFNG \| IGF2 \| IL6 \| MPO \| NOS3 \| PARP1 \| SOD1 \| SOD2 \| STAT3 \| TNF \| TRIM28 \| VCAM1 \| VEGFA	12.61	24
36.	Cocaine	Subarachnoid Hemorrhage	M	10 genes ADORA1 \| CASP3 \| EDN1 \| EDNRB \| IL1B \| IL6 \| MMP9 \| NTN1 \| RELA \| TNF	12.18	25
37.	Crack Cocaine	Brain Ischemia	M	6 genes ACE \| HIF1A \| IL6 \| MAP2K1 \| MAPK3 \| SOD1	11.72	10
38.	epibatidine	Seizures	M	5 genes CHRNA3 \| CHRNA4 \| CHRNA5 \| CHRNA7 \| CHRNB4	11.29	9
39.	Cocaine	Developmental Disabilities	M	10 genes AS3MT \| CHRNA4 \| DRD2 \| KCNT1 \| MAPK3 \| MECP2 \| NTRK2 \| PTEN \| SHANK3 \| SLC4A4	11.18	19
40.	Cocaine	Kidney Failure, Chronic	M	14 genes ACE \| CAT \| CCL2 \| CRP \| CYBA \| CYBB \| IL6 \| MYH9 \| NCF1 \| NFKB1 \| NGF \| RELA \| SCARB1 \| TNF	10.94	12
41.	Cocaine	Ischemic Attack, Transient	M	8 genes ADORA1 \| BAD \| CASP9 \| CYCS \| ILK \| NDRG2 \| SOD1 \| SOD2	9.86	15
42.	Cocaine	Heart Valve Diseases	M	8 genes ADAMTS19 \| CASP3 \| CCL2 \| COL1A1 \| FGFR1 \| IL1B \| JAK2 \| LSP1	9.73	6
43.	Crack Cocaine	Heart Failure	M	8 genes ACE \| CXCL8 \| HIF1A \| IL6 \| MAP2K1 \| MAPK10 \| POMC \| SOD1	9.66	10
44.	Cocaine	Hypertension, Pulmonary	M	14 genes ACE \| BMPR2 \| BRD4 \| CCL2 \| CXCL8 \| EDN1 \| EDNRB \| FOXO1 \| HIF1A \| LOX \| NOS3 \| SLC6A4 \| SOD2 \| TNF	9.48	28
45.	2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	Cocaine-Related Disorders	M	2 genes SLC6A3 \| SLC6A4	9.41	5
46.	Scopolamine	Chemical and Drug Induced Liver Injury	M	15 genes ABCB1 \| AGT \| BAX \| CAT \| GSR \| HMOX1 \| HRH2 \| IFNG \| IL1A \| IL1B \| IL6 \| ITPR1 \| NFE2L2 \| PTGS2 \| TNF	8.99	28
47.	Cocaine	Pregnancy Complications, Cardiovascular	M	4 genes FAS \| IL6 \| PRL \| TNF	8.94	4
48.	Cocaine	Coronary Artery Disease	M	14 genes ACE \| APCS \| CCL2 \| CRP \| GUCY1A1 \| KL \| MAT2A \| MRAS \| NOS3 \| PECAM1 \| PLPP3 \| SLC5A3 \| TRIB1 \| VEGFA	8.68	33
49.	Cocaine	Inflammation	M	39 genes AGT \| AKT1 \| BDNF \| CCL2 \| CCL3 \| CHRNA4 \| CHRNB2 \| CRP \| CXCL8 \| CYP3A23-3A1 \| EDN1 \| EFNB1 \| EGR1 \| FGF2 \| FNDC5 \| GAL \| ICAM1 \| IFNG \| IKBKB \| IL10 \| IL1A \| IL1B \| IL4I1 \| IL6 \| JAK2 \| MBP \| MMP9 \| MPO \| NGF \| PARP1 \| SELENOS \| SOD1 \| STAT3 \| TAC1 \| TF \| TFRC \| TNF \| TNFRSF11B \| VEGFA	8.62	68
50.	Cocaine	Memory Disorders	M	26 genes APP \| BCL2 \| CALY \| CHRM1 \| CNR1 \| DRD2 \| GRPR \| HTR1A \| HTR2A \| HTR6 \| IGF2 \| IL1B \| INS \| KL \| NPY \| NQO2 \| PRL \| REL \| SIGMAR1 \| SLC17A6 \| SLC17A7 \| SLC6A3 \| SLC6A4 \| STAT3 \| SYP \| VEGFA	8.55	63

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