Illuminating how chemicals affect human health.
Comparative Toxicogenomics Database

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	Chemical	Phenotype	Co-Mentioned Terms	Interaction	Organisms	Anatomy	Inference Network	References
1.	1',2'-dihydrorotenone	apoptotic process		1',2'-dihydrorotenone results in increased apoptotic process	1: Homo sapiens	Plasma Cells	6 genes AKT1 | E2F1 | MAPK1 | MAPK3 | RB1 | TP53	1
2.	1',2'-dihydrorotenone	negative regulation of mitotic cell cycle		1',2'-dihydrorotenone results in increased negative regulation of mitotic cell cycle	1: Homo sapiens	Plasma Cells	2 genes RB1 | TP53	1
3.	1',2'-dihydrorotenone	cell population proliferation		1',2'-dihydrorotenone results in decreased cell population proliferation	1: Homo sapiens	Plasma Cells | Cell Line, Tumor	3 genes AKT1 | RB1 | TP53	1
4.	1',2'-dihydrorotenone	negative regulation of mitotic cell cycle		1',2'-dihydrorotenone results in increased negative regulation of mitotic cell cycle	1: Homo sapiens	Plasma Cells | Cell Line, Tumor	2 genes RB1 | TP53	1
5.	3'-hydroxydaidzein	cell population proliferation		3'-hydroxydaidzein affects cell population proliferation	1: Homo sapiens	Caco-2 Cells		1
6.	3'-hydroxydaidzein	cell population proliferation	Fulvestrant	Fulvestrant affects the reaction [3'-hydroxydaidzein affects cell population proliferation]	1: Homo sapiens	Caco-2 Cells		1
7.	5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one	angiogenesis		5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one results in decreased angiogenesis			4 genes CCL2 | CXCL8 | PTGS2 | VEGFA	1
8.	5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one	cell population proliferation		5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one results in decreased cell population proliferation	1: Homo sapiens	Human Umbilical Vein Endothelial Cells	2 genes AKT1 | VEGFA	1
9.	5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one	cell migration	FGF2	5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one inhibits the reaction [FGF2 protein results in increased cell migration]	1: Homo sapiens	Human Umbilical Vein Endothelial Cells	1 gene VEGFA	1
10.	5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one	cell population proliferation		5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one analog results in decreased cell population proliferation	1: Homo sapiens	Human Umbilical Vein Endothelial Cells	2 genes AKT1 | VEGFA	1
11.	5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one	cell population proliferation		5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one analog results in decreased cell population proliferation	1: Homo sapiens	Retina | Microvessels | Endothelial Cells	2 genes AKT1 | VEGFA	1
12.	5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one	angiogenesis		5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one analog results in decreased angiogenesis	1: Homo sapiens	Retina | Microvessels | Endothelial Cells	4 genes CCL2 | CXCL8 | PTGS2 | VEGFA	1
13.	6,8-diprenylgenistein	cAMP-dependent protein kinase activity		6,8-diprenylgenistein results in decreased cAMP-dependent protein kinase activity	1: Rattus norvegicus	Liver		1
14.	7,3'-dihydroxy-4'-methoxyisoflavone	cell population proliferation		7,3'-dihydroxy-4'-methoxyisoflavone results in decreased cell population proliferation	1: Homo sapiens	Hepatocytes | Cell Line, Tumor	5 genes EPO | ESR2 | PRDX1 | TGFB1 | VEGFA	1
15.	7,3'-dihydroxy-4'-methoxyisoflavone	lipid catabolic process	Dietary Fats | Malondialdehyde | Streptozocin	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[[Dietary Fats co-treated with Streptozocin] results in increased lipid catabolic process] which results in increased abundance of Malondialdehyde]	1: Rattus norvegicus	Kidney		1
16.	7,3'-dihydroxy-4'-methoxyisoflavone	extracellular matrix assembly	Dietary Fats | glomerular basement membrane development | Streptozocin	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[[Dietary Fats co-treated with Streptozocin] affects glomerular basement membrane development] which results in increased extracellular matrix assembly]	1: Rattus norvegicus	Kidney	1 gene TGFB1	1
17.	7,3'-dihydroxy-4'-methoxyisoflavone	glomerular basement membrane development	Dietary Fats | extracellular matrix assembly | Streptozocin	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[[Dietary Fats co-treated with Streptozocin] affects glomerular basement membrane development] which results in increased extracellular matrix assembly]	1: Rattus norvegicus	Kidney		1
18.	7,3'-dihydroxy-4'-methoxyisoflavone	collagen fibril organization	Dietary Fats | glomerular basement membrane development | Streptozocin	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[[Dietary Fats co-treated with Streptozocin] affects glomerular basement membrane development] which results in increased collagen fibril organization]	1: Rattus norvegicus	Kidney		1
19.	7,3'-dihydroxy-4'-methoxyisoflavone	glomerular basement membrane development	collagen fibril organization | Dietary Fats | Streptozocin	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[[Dietary Fats co-treated with Streptozocin] affects glomerular basement membrane development] which results in increased collagen fibril organization]	1: Rattus norvegicus	Kidney		1
20.	7,3'-dihydroxy-4'-methoxyisoflavone	lipid droplet formation	Dietary Fats | Streptozocin	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased lipid droplet formation]	1: Rattus norvegicus	Kidney Tubules, Proximal | Epithelial Cells		1
21.	7,3'-dihydroxy-4'-methoxyisoflavone	mitochondrion organization	Dietary Fats | Streptozocin	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased mitochondrion organization]	1: Rattus norvegicus	Kidney Tubules, Proximal | Epithelial Cells | Mitochondria	4 genes GSK3B | NRF1 | PPARGC1A | SIRT1	1
22.	7,3'-dihydroxy-4'-methoxyisoflavone	cellular metabolic process	triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased cellular metabolic process]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line		1
23.	7,3'-dihydroxy-4'-methoxyisoflavone	apoptotic process	triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased apoptotic process]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line	10 genes APP | CASP3 | EPO | HIF1A | IL1B | MAPK1 | MAPK3 | SIRT1 | TGFB1 | VEGFA	1
24.	7,3'-dihydroxy-4'-methoxyisoflavone	mitochondrial DNA replication	mitochondrion | triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide results in decreased mitochondrial DNA replication] which results in decreased mitochondrion]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria		1
25.	7,3'-dihydroxy-4'-methoxyisoflavone	mitochondrion	mitochondrial DNA replication | triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide results in decreased mitochondrial DNA replication] which results in decreased mitochondrion]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria	12 genes APP | ATP5F1A | ESR2 | GSK3B | MAPK1 | MAPK3 | MAPT | NDUFB8 | SDHB | SIRT1 | TFAM | UQCRC2	1
26.	7,3'-dihydroxy-4'-methoxyisoflavone	regulation of mitochondrial membrane potential	triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide affects regulation of mitochondrial membrane potential]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria		1
27.	7,3'-dihydroxy-4'-methoxyisoflavone	mitochondrial depolarization	triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased mitochondrial depolarization]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria		1
28.	7,3'-dihydroxy-4'-methoxyisoflavone	mitochondrial depolarization	regulation of mitochondrial membrane potential | triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide affects regulation of mitochondrial membrane potential] which results in increased mitochondrial depolarization]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria		1
29.	7,3'-dihydroxy-4'-methoxyisoflavone	regulation of mitochondrial membrane potential	mitochondrial depolarization | triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide affects regulation of mitochondrial membrane potential] which results in increased mitochondrial depolarization]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria		1
30.	7,3'-dihydroxy-4'-methoxyisoflavone	cellular respiration	triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased cellular respiration]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria	2 genes PPARGC1A | UQCRC2	1
31.	7,3'-dihydroxy-4'-methoxyisoflavone	cellular respiration	triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased cellular respiration]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line	2 genes PPARGC1A | UQCRC2	1
32.	7,3'-dihydroxy-4'-methoxyisoflavone	ATP metabolic process	Adenosine Triphosphate | triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide affects ATP metabolic process] which results in decreased abundance of Adenosine Triphosphate]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line	1 gene ATP5F1A	1
33.	7,3'-dihydroxy-4'-methoxyisoflavone	ATP metabolic process	Adenosine Triphosphate | NRF1 | triptolide	NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide affects ATP metabolic process] which results in decreased abundance of Adenosine Triphosphate]]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line	1 gene ATP5F1A	1
34.	7,3'-dihydroxy-4'-methoxyisoflavone	NAD metabolic process	NAD | triptolide	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide affects NAD metabolic process] which results in decreased abundance of NAD]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line		1
35.	7,3'-dihydroxy-4'-methoxyisoflavone	mitochondrial DNA replication	mitochondrion | SR18292 | triptolide	SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide results in decreased mitochondrial DNA replication] which results in decreased mitochondrion]]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria		1
36.	7,3'-dihydroxy-4'-methoxyisoflavone	mitochondrion	mitochondrial DNA replication | SR18292 | triptolide	SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide results in decreased mitochondrial DNA replication] which results in decreased mitochondrion]]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line | Mitochondria	12 genes APP | ATP5F1A | ESR2 | GSK3B | MAPK1 | MAPK3 | MAPT | NDUFB8 | SDHB | SIRT1 | TFAM | UQCRC2	1
37.	7,3'-dihydroxy-4'-methoxyisoflavone	ATP metabolic process	Adenosine Triphosphate | SR18292 | triptolide	SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[triptolide affects ATP metabolic process] which results in decreased abundance of Adenosine Triphosphate]]	1: Rattus norvegicus	Embryo, Mammalian | Heart | Myocytes, Cardiac | Cell Line	1 gene ATP5F1A	1
38.	7,3'-dihydroxy-4'-methoxyisoflavone	metabolic process	Glycation End Products, Advanced	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced affects metabolic process]	1: Rattus norvegicus	PC12 Cells		1
39.	7,3'-dihydroxy-4'-methoxyisoflavone	visual learning	Glycation End Products, Advanced	7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced affects visual learning]	1: Rattus norvegicus		2 genes APP | HIF1A	1
40.	7-difluoromethyl-5,4'-dimethoxygenistein	cellular metabolic process		7-difluoromethyl-5,4'-dimethoxygenistein results in decreased cellular metabolic process	1: Homo sapiens	HL-60 Cells		1
41.	auriculasin	cell population proliferation		auriculasin results in decreased cell population proliferation	1: Homo sapiens	Human Umbilical Vein Endothelial Cells	5 genes AKT1 | BAX | BCL2 | TP53 | VEGFA	1
42.	auriculasin	wound healing, spreading of cells	VEGFA	auriculasin inhibits the reaction [VEGFA protein results in increased wound healing, spreading of cells]	1: Homo sapiens	Human Umbilical Vein Endothelial Cells		1
43.	auriculasin	branching involved in blood vessel morphogenesis	VEGFA	auriculasin inhibits the reaction [VEGFA protein results in increased branching involved in blood vessel morphogenesis]	1: Homo sapiens	Human Umbilical Vein Endothelial Cells	2 genes KDR | VEGFA	1
44.	auriculasin	branching involved in blood vessel morphogenesis	VEGFA	auriculasin inhibits the reaction [VEGFA protein results in increased branching involved in blood vessel morphogenesis]	1: Rattus norvegicus	Aorta | Microvessels	2 genes KDR | VEGFA	1
45.	auriculasin	apoptotic process	TNFSF10	[auriculasin co-treated with TNFSF10 protein] results in increased apoptotic process		Prostate | Tumor Cells, Cultured	17 genes AIFM1 | AKT1 | BAX | BCL2 | BCL2L1 | CASP10 | CASP3 | CASP8 | CASP9 | DDIT3 | MAPK1 | MAPK3 | PARP1 | TNFRSF10B | TNFSF10 | TP53 | VEGFA	1
46.	auriculasin	cellular response to DNA damage stimulus		auriculasin results in increased cellular response to DNA damage stimulus	1: Homo sapiens	Prostate | Tumor Cells, Cultured	12 genes AKT1 | BAX | BCL2 | CASP3 | CASP9 | DDIT3 | ENDOG | MAPK1 | MAPK3 | MTOR | PARP1 | TP53	1
47.	auriculasin	cellular response to DNA damage stimulus	TNFSF10	[auriculasin co-treated with TNFSF10 protein] results in increased cellular response to DNA damage stimulus		Prostate | Tumor Cells, Cultured	12 genes AKT1 | BAX | BCL2 | CASP3 | CASP9 | DDIT3 | ENDOG | MAPK1 | MAPK3 | MTOR | PARP1 | TP53	1
48.	auriculasin	apoptotic process	benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane | TNFSF10	benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased apoptotic process]		Prostate | Tumor Cells, Cultured	17 genes AIFM1 | AKT1 | BAX | BCL2 | BCL2L1 | CASP10 | CASP3 | CASP8 | CASP9 | DDIT3 | MAPK1 | MAPK3 | PARP1 | TNFRSF10B | TNFSF10 | TP53 | VEGFA	1
49.	auriculasin	apoptotic process	N-phenylmaleimide | TNFSF10	N-phenylmaleimide inhibits the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased apoptotic process]		Prostate | Tumor Cells, Cultured	17 genes AIFM1 | AKT1 | BAX | BCL2 | BCL2L1 | CASP10 | CASP3 | CASP8 | CASP9 | DDIT3 | MAPK1 | MAPK3 | PARP1 | TNFRSF10B | TNFSF10 | TP53 | VEGFA	1
50.	auriculasin	release of cytochrome c from mitochondria		auriculasin results in increased release of cytochrome c from mitochondria		Prostate | Tumor Cells, Cultured	4 genes BAX | BCL2 | BCL2L1 | TP53	1

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