Heterocyclic Compounds, 4 or More Rings - Diseases

These diseases are associated with Heterocyclic Compounds, 4 or More Rings or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 47,542 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	zinc protoporphyrin	Reperfusion Injury	M	31 genes AGT \| BCL2 \| CASP3 \| CASP8 \| CAT \| CCL2 \| CDKN1A \| CXCL1 \| CXCL2 \| FOS \| GPX1 \| HMOX1 \| ICAM1 \| IL10 \| IL1B \| IL6 \| INPP5D \| IRAK3 \| JUN \| MMP9 \| MPO \| MYD88 \| NOS2 \| PPARG \| PTGS2 \| RELA \| SOD2 \| STAT3 \| TLR2 \| TLR4 \| TNF	100.96	43
2.	Rotenone	Disease Models, Animal	M	105 genes ABCB1B \| ABCB4 \| ABCC6 \| AHCY \| AIF1 \| AKT1 \| ALB \| ALDH18A1 \| ALDH5A1 \| ANP32A \| APEX1 \| APP \| ARG1 \| BDKRB2 \| BZW2 \| CAR2 \| CCT5 \| CDH2 \| CLDN11 \| CNR2 \| COL2A1 \| CTNNB1 \| DEK \| DHCR7 \| EIF2B1 \| EIF3E \| ENO1 \| ESR1 \| FAS \| FASN \| FBL \| FOS \| GAPDH \| GFAP \| GPI1 \| GRWD1 \| HBB \| HK1 \| HK2 \| HMGB2 \| HNRNPA1 \| IDH2 \| IFNG \| IL10 \| IL1B \| IMPDH2 \| IPO4 \| KNG1 \| KPNA2 \| LDHA \| LEPR \| LMNB1 \| MAPK1 \| MAPK3 \| MAPK8 \| MAPK9 \| MAPT \| MMP9 \| MYC \| NFE2L2 \| NOP56 \| NOP58 \| NPM1 \| NPM3 \| NPPB \| NR1H4 \| NUDT21 \| PABPC4 \| PCBD1 \| PRKN \| PSAT1 \| RFC4 \| RHOA \| RPL10A \| RPL13A \| RPL27A \| RRM2 \| RSAD2 \| S100A10 \| SATB1 \| SERPINE1 \| SHMT1 \| SLC29A1 \| SLC4A4 \| SNCA \| SNRPG \| SOD1 \| SRM \| STAT3 \| TBX20 \| TCF7L2 \| TFAM \| TG \| TIMP1 \| TK1 \| TNF \| TOMM40 \| TOP2A \| TRP53 \| TYMS \| UCK2 \| VCP \| VIM \| XRCC5 \| XRCC6	63.05	90
3.	Morphine	Status Epilepticus	M	27 genes ABCB1A \| AQP4 \| BDNF \| BECN1 \| CASP1 \| CASP3 \| CASP8 \| CAT \| CCL2 \| CCL3 \| CNR1 \| CRH \| EIF2AK3 \| FOS \| GRIA2 \| GRM1 \| GRM5 \| HMOX1 \| HSPB1 \| IL1RN \| JUN \| JUNB \| NOS1 \| NOS2 \| PTGS2 \| TNF \| VEGFA	46.64	31
4.	Hemin	Cell Transformation, Neoplastic	M	18 genes ARL6IP5 \| BCL2 \| CAT \| CDH1 \| FOS \| GCLC \| HIF1A \| IL6 \| JUN \| MAPK8 \| MYC \| NFE2L2 \| NOS2 \| POR \| PTEN \| RELA \| SOD2 \| TFRC	44.89	29
5.	Rifampin	Fatty Liver	M	31 genes ANGPTL4 \| APOB \| ATF4 \| CAT \| CCL2 \| CEBPB \| CYP1B1 \| CYP2E1 \| DDIT3 \| FOXA1 \| GPT \| GPX4 \| INS \| LDLR \| LEP \| MIR148B \| MIR197 \| MIR34A \| MTTP \| NFE2L2 \| NR0B2 \| NR1H3 \| NR1H4 \| NR1I2 \| PON1 \| PPARA \| SCD1 \| SERPINE1 \| SLC13A5 \| SLC2A2 \| TNF	44.03	36
6.	Morphine	Myocardial Ischemia	M	29 genes AGT \| CCL2 \| CCL3 \| CD38 \| CIRBP \| CRP \| CX3CL1 \| DUSP6 \| EGR2 \| EIF2AK3 \| EPHX2 \| FGF2 \| HMGCS2 \| HMOX1 \| HSPA1A \| ICAM1 \| IL1A \| IL1B \| IL6 \| JUNB \| MAPK14 \| NFKBIA \| NR4A1 \| POMC \| PPP3R1 \| SOD2 \| SULT1A1 \| TNF \| VEGFA	40.92	13
7.	diosbulbin B	Chemical and Drug Induced Liver Injury	M	26 genes ABCC2 \| CAT \| COL3A1 \| CYP8B1 \| ENO1 \| FASN \| GPT \| IL6 \| MIR122 \| MIR132 \| MIR192 \| MIR193A \| MIR194-1 \| MIR34A \| MIR378A \| MIR452 \| MIR5099 \| NR0B2 \| NR1H4 \| NR5A2 \| PPARA \| PYGL \| SOD1 \| SOD2 \| TNF \| VIM	40.04	35
8.	Rifampin	Cholestasis	M	27 genes ABCB11 \| ABCC2 \| ABCC3 \| CAT \| CYP1A2 \| CYP27A1 \| CYP2B10 \| CYP3A11 \| CYP4A14 \| CYP7A1 \| CYP8B1 \| EGR1 \| IL6 \| MIR143 \| NFE2L2 \| NOS2 \| NR1H3 \| NR1H4 \| PON1 \| SERPINE1 \| SLC23A2 \| SLC30A10 \| SLC51A \| SLC51B \| SLCO1A1 \| SLCO1A4 \| TNF	37.87	23
9.	Rotenone	Parkinson Disease	M	60 genes ABCB1 \| AIF1 \| ALDH2 \| ATP13A2 \| BAG5 \| BDNF \| CEACAM6 \| CNTNAP2 \| CP \| CYP2E1 \| DDC \| DDIT4 \| DNM1L \| DRD1 \| DRD2 \| EDN1 \| ENO2 \| FCER2 \| GBA1 \| GDNF \| GFAP \| GPX1 \| GSTA4 \| GSTM1 \| GSTP1 \| HFE \| HMOX1 \| HSPA1A \| HSPA9 \| IGF2 \| IGF2R \| IL6 \| KCNJ4 \| LRRK2 \| MAOA \| MAP2 \| MAP3K5 \| MAPT \| MTA1 \| NCAPG2 \| NECTIN2 \| NGF \| NQO1 \| PARK7 \| PINK1 \| PPARGC1A \| PRKN \| RPL14 \| RPL6 \| SLC18A2 \| SLC30A10 \| SLC38A2 \| SLC6A3 \| SNCA \| SOD1 \| SOD2 \| TALDO1 \| TH \| TNF \| TRPM2	37.42	108
10.	Naloxone	Myocardial Infarction	M	18 genes ACTA2 \| AGT \| BAX \| BCL2 \| CASP3 \| CAT \| GSK3B \| HSPA5 \| ICAM1 \| IL1B \| IL6 \| LGALS3 \| MMP9 \| NPPA \| PLAT \| REN \| SELL \| TNF	34.32	49
11.	Morphine	Disease Progression	M	22 genes ABCB1 \| APOE \| ARG2 \| BCL2 \| CAT \| CCR5 \| CTSB \| EHD1 \| FAS \| FGF2 \| HNRNPL \| IDH3B \| IL1A \| IL1B \| MIR21 \| MMP9 \| RELA \| SOD2 \| SUCLG1 \| TMEM63A \| TNF \| TP53	31.83	23
12.	Morphine	Drug-Related Side Effects and Adverse Reactions	M	33 genes ABCB1 \| ABCB1A \| ABCG2 \| ACHE \| ADORA1 \| ADORA2A \| ALB \| APOB \| ATIC \| BCHE \| CCL2 \| CES2 \| CXCL8 \| CYP1A2 \| CYP2D6 \| EPHX2 \| FGA \| HMOX1 \| HOMER1 \| HP \| IFNG \| IL10 \| IL1RN \| IL6 \| LCN2 \| NR3C1 \| PLG \| PTGS2 \| TLR2 \| TNF \| TTR \| UGT1A1 \| VEGFA	31.73	36
13.	Rotenone	Lewy Body Disease	M	17 genes AGER \| AIF1 \| BECN1 \| EDN1 \| ENO2 \| GBA1 \| GFAP \| IGF2 \| IGF2R \| MAP2 \| NGF \| NTRK1 \| NTRK2 \| PPARGC1A \| SNCA \| SOD2 \| TH	30.66	8
14.	zinc protoporphyrin	Chemical and Drug Induced Liver Injury	M	27 genes ADIPOQ \| AGT \| ALB \| BAX \| CAT \| CCL2 \| CXCL1 \| CXCL10 \| CYP1A1 \| CYP1A2 \| CYP2A5 \| CYP2E1 \| FLT1 \| HMGB1 \| HMOX1 \| IFNG \| IL12B \| IL18 \| IL1B \| IL6 \| IRAK1 \| MMP2 \| MMP9 \| NFE2L2 \| PTGS2 \| SOD2 \| TNF	30.50	40
15.	Rifampin	Drug-Related Side Effects and Adverse Reactions	M	30 genes ABCB1 \| ABCB1A \| ABCC1 \| ABCC2 \| ABCG2 \| ADORA2A \| APOB \| CCL2 \| CES2 \| CYP1A2 \| CYP2C8 \| CYP2C9 \| CYP2D6 \| CYP2E1 \| GSTA1 \| HMOX1 \| IFNG \| IGFBP1 \| IL10 \| IL6 \| NFE2L2 \| NR3C1 \| PPARA \| SLCO1B1 \| SLCO2A1 \| TLR1 \| TNF \| UGT1A1 \| VEGFA \| VKORC1	29.71	33
16.	Heme	Diabetes Mellitus, Experimental	M	12 genes ADRA1A \| ESRRA \| HMOX1 \| IFNG \| IL1B \| IL6 \| MPO \| NOS2 \| PCSK2 \| RELA \| TGFB1 \| TNF	29.68	15
17.	Hemin	Colorectal Neoplasms	M	14 genes AKT1 \| ALDH2 \| BAX \| BCL2 \| CDH1 \| CYP1A2 \| GSTM1 \| MMP1 \| MYC \| NQO1 \| SESN2 \| SOD2 \| TFRC \| TNF	29.48	15
18.	Bilirubin	Cholestasis, Extrahepatic	M	11 genes ALB \| COL3A1 \| IL1B \| IL6 \| MAPK1 \| MAPK3 \| MMP9 \| NFE2L2 \| NOS2 \| RELA \| TNF	28.71	2
19.	zinc protoporphyrin	Acute Lung Injury	M	11 genes CASP3 \| CAT \| CXCL2 \| FASLG \| ICAM1 \| IL1B \| IL6 \| NFE2L2 \| PPARG \| TGFB1 \| TNF	27.79	10
20.	chromium mesoporphyrin	Hypertension	M	9 genes ADIPOQ \| CXCL2 \| EDN1 \| HMOX1 \| ICAM1 \| IL6 \| JUN \| RELA \| TNF	27.51	27
21.	Hemin	Cardiomegaly	M	12 genes AKT1 \| CYP1A1 \| CYP2E1 \| HIF1A \| HMOX1 \| IL18 \| IL1B \| MT2A \| NOS3 \| SLC2A4 \| SOD2 \| TNF	26.44	16
22.	Protoporphyrins	Protoporphyria, Erythropoietic	M	3 genes AREG \| BTC \| EREG	26.07	2
23.	Morphine	Chemical and Drug Induced Liver Injury	M	51 genes ABCB1 \| ABCB1A \| AGT \| ALB \| ANXA6 \| APOA1 \| APOE \| BAX \| CAP1 \| CAT \| CCL2 \| COQ9 \| CRP \| CXCL1 \| CYP1A2 \| CYP2B6 \| CYP2C19 \| FGA \| HMOX1 \| HRH2 \| HSPA5 \| IFNG \| IL12B \| IL1A \| IL1B \| IL4 \| IL6 \| KRT8 \| LCN2 \| MIR107 \| MIR132 \| MIR150 \| MIR191 \| MIR21 \| MIR221 \| MIR23A \| MIR23B \| MIR320A \| MIR423 \| MMP9 \| PLAT \| PLG \| PRKCD \| PTGS2 \| SERPING1 \| SOD2 \| TNF \| TTR \| UGT1A9 \| VEGFA \| VIM	25.81	42
24.	Heme	Inflammation	M	16 genes ATP7B \| CCL2 \| CCL3 \| CSF2 \| CXCL2 \| HMOX1 \| IFNG \| IL1A \| IL1B \| IL6 \| MPO \| MYD88 \| NOS2 \| TGFB1 \| TLR4 \| TNF	25.21	49
25.	sanguinarine	Chemical and Drug Induced Liver Injury	M	18 genes AHR \| ARNT \| BAX \| BRD4 \| CAT \| CTNNB1 \| CYP1A1 \| CYP1A2 \| CYP1B1 \| CYP2E1 \| CYP3A23-3A1 \| GSR \| GSTP1 \| MMP2 \| MMP9 \| SOD1 \| TNF \| VIM	25.17	24
26.	Rifampin	Liver Neoplasms	M	23 genes AHR \| ATF3 \| CCND1 \| CDKN1A \| CDKN2B \| CXCL1 \| CYP2E1 \| GPX2 \| GSTM1 \| HGF \| HMOX1 \| JUN \| MIR29A \| NCOR1 \| NFE2L2 \| NR1H4 \| NR1I3 \| PPARA \| PPARG \| SERPINE1 \| TNF \| TNFSF10 \| UGDH	24.93	29
27.	Morphine	Acute Kidney Injury	M	28 genes ALB \| AVP \| BAX \| CCR5 \| CYP2C19 \| CYP2D6 \| EPHX2 \| GSK3B \| HMOX1 \| HP \| HSPA1A \| IL10 \| IL6 \| LCN2 \| MIR23A \| NFKB1 \| NOS2 \| PLG \| POMC \| TGFB1 \| TLR2 \| TLR4 \| TNF \| TP53 \| TTR \| UGT1A1 \| UGT1A9 \| VEGFA	23.40	30
28.	Rifampin	Acute Kidney Injury	M	26 genes BAX \| CYP2C19 \| CYP2C9 \| CYP2D6 \| CYP3A23-3A1 \| EDN1 \| GSTA1 \| GSTP1 \| HBEGF \| HMOX1 \| IGFBP1 \| IL10 \| IL6 \| INS \| MIR143 \| MIR192 \| MIR215 \| MPO \| NFE2L2 \| NOS2 \| OCLN \| PPARG \| TNF \| UGT1A1 \| UGT1A9 \| VEGFA	22.89	136
29.	Morphine	Bipolar Disorder	M	17 genes BDNF \| COMT \| DRD1 \| GAD1 \| GAD2 \| GRIN2A \| GSK3B \| HDAC5 \| NDUFV2 \| NR3C1 \| NTNG1 \| POMC \| PVALB \| RELN \| S100B \| TAC1 \| TACR1	22.65	18
30.	Morphine	Hypotension	M	27 genes ADORA1 \| ADORA2A \| AGT \| ALB \| AVP \| CAT \| CNR1 \| CRH \| DRD1 \| DRD2 \| GRIA1 \| GRIN2B \| HRH1 \| IFNG \| IL1A \| IL1B \| IL2 \| IL6 \| OXT \| PDYN \| PLAT \| PNOC \| POMC \| PRL \| TAC1 \| TNF \| VIP	21.96	66
31.	Apomorphine	Schizophrenia	M	9 genes AVP \| DRD1 \| DRD2 \| DRD3 \| HTR6 \| IL6 \| PVALB \| RGS9 \| TAC1	21.95	13
32.	Morphine	Epilepsy	M	16 genes ABCB1 \| AKT1 \| ALB \| BDNF \| FOS \| FOSB \| GFAP \| GRIN2A \| GRIN2B \| GRM1 \| NPY \| OPRD1 \| OPRM1 \| POMC \| SLC6A1 \| TGFB1	21.81	20
33.	Rotenone	Chemical and Drug Induced Liver Injury	M	189 genes AASS \| ABCB1 \| ABCB1A \| ABCB1B \| ABCC2 \| ACSL1 \| ACTB \| ADAM8 \| ADIPOQ \| ADORA2B \| AGT \| AIFM1 \| ALB \| ALDH1L2 \| ALDH9A1 \| ALDOB \| ANXA2 \| ANXA6 \| APOA1 \| APOE \| ARG1 \| ARNT \| ATG5 \| ATP6V1D \| BAX \| BDH1 \| BDKRB2 \| BLVRB \| BMAL1 \| C3 \| CA3 \| CADPS2 \| CANX \| CAR3 \| CAT \| CCDC80 \| CCL2 \| CCR2 \| CCT3 \| CCT5 \| CDC25B \| CDS1 \| CKB \| CLU \| COL14A1 \| COL3A1 \| CP \| CRP \| CTNNB1 \| CTSE \| CXCL1 \| CXCL10 \| CYP2C11 \| CYP2E1 \| CYP3A23-3A1 \| CYP8B1 \| DHFR \| DHRS7 \| DLAT \| DNAJB9 \| DNAJC12 \| ECHDC1 \| EIF4EBP2 \| ENO1 \| EPHX1 \| ERN1 \| FADS1 \| FADS2 \| FASN \| FGA \| FLT1 \| FTL1 \| GADD45A \| GCLC \| GCLM \| GDA \| GDI1 \| GGH \| GLUD1 \| GOT1 \| GPD1 \| GPT \| GSR \| GSTA1 \| GSTA4 \| GSTM1 \| GSTM2 \| GSTM3 \| GSTM4 \| GSTO1 \| GSTP1 \| GULO \| HADHA \| HAO2 \| HAVCR1 \| HBA-A1 \| HMOX1 \| HPRT1 \| HSPA5 \| IDO2 \| IFNG \| IGF1 \| IL11 \| IL12B \| IL18 \| IL1A \| IL1B \| IL4 \| IL6 \| IRAK1 \| ITPR1 \| JUND \| KNG1 \| KRT18 \| KRT8 \| LBP \| LCN2 \| LDLR \| LGALS3 \| LRAT \| MALAT1 \| MAP1LC3B \| MAP3K5 \| ME1 \| MED1 \| MIR122 \| MIR141 \| MIR210 \| MIR22 \| MIR34A \| MIR34C \| MIR410 \| MIR484 \| MIR505 \| MMP2 \| MMP9 \| MST1R \| NDUFS3 \| NFATC4 \| NFE2L2 \| NME2 \| NOTCH1 \| NOX4 \| NR0B2 \| NR1H4 \| NR1I3 \| NREP \| NTN1 \| OBP3 \| OGDH \| PARK7 \| PC \| PDK4 \| PEX11A \| PGM1 \| PNRC1 \| POLG \| PPARA \| PRKCD \| PTGS2 \| PYGL \| RGN \| RIPK3 \| S100A11 \| SEMA3A \| SESN2 \| SLC13A4 \| SLC22A8 \| SLPI \| SOD1 \| SOD2 \| SOD3 \| SORL1 \| SPP1 \| SULT1E1 \| TAGLN2 \| TALDO1 \| TCTN1 \| THBS1 \| TLR5 \| TNF \| TTR \| TUBA1A \| TUBB4B \| VEGFA \| VIM \| WASL \| XYLB \| ZDHHC23	21.25	112
34.	Morphine	Cholestasis	M	20 genes AGT \| BEX4 \| CAT \| CNR1 \| CXCL8 \| CYP1A2 \| CYP27A1 \| EGR1 \| FGA \| ICAM1 \| IL6 \| MAPK14 \| NOS2 \| PDYN \| POMC \| RELA \| SERPINE1 \| SLC23A2 \| TLR2 \| TNF	20.98	13
35.	stannous mesoporphyrin	Hypertension	M	7 genes ADIPOQ \| CCL2 \| FN1 \| HMOX1 \| NOS3 \| PTPN1 \| SOD2	20.96	17
36.	Bilirubin	Cholestasis	M	20 genes ABCB11 \| ABCC2 \| AGT \| BLVRA \| CAT \| CXCL2 \| CXCL8 \| CYP1A2 \| CYP7A1 \| EGR1 \| HSD3B7 \| IL6 \| NFE2L2 \| NOS2 \| RELA \| SERPINE1 \| SLC23A1 \| SLC23A2 \| TNF \| VIL1	19.43	17
37.	Heme	Diabetes Mellitus, Type 2	M	10 genes HMOX1 \| HPX \| IL6 \| ITLN1 \| NFKB1 \| NOS2 \| PCSK2 \| RELA \| TGFB1 \| TNF	19.38	9
38.	Morphine	Morphine Dependence	M	7 genes CREB1 \| GRIA1 \| GRIN2A \| MMP9 \| NOS1 \| OPRL1 \| OPRM1	18.81	105
39.	Rifampin	Pancreatitis	M	12 genes HGF \| INS \| MIR192 \| MIR200A \| MIR20B \| MIR215 \| MIR22 \| MIR29A \| MIR31 \| MIR532 \| MPO \| PARP1	18.48	6
40.	Morphine	Hypoxia	M	12 genes APOA1 \| ATF4 \| BDNF \| EGR1 \| GAPDH \| GNAS \| NOS1 \| PDYN \| PLAT \| POMC \| SOD2 \| TKT	18.07	13
41.	Rotenone	Tremor	M	2 genes ACHE \| ADORA2A	17.93	4
42.	Morphine	Fever	M	18 genes CCK \| CRH \| CXCL8 \| HTR1A \| IFNG \| IL1A \| IL1B \| IL1RN \| IL2 \| IL6 \| NOS1 \| POMC \| PRKCD \| PRL \| PTGS2 \| SOD2 \| STAT3 \| TNF	17.83	23
43.	chromium mesoporphyrin	Insulin Resistance	M	5 genes ADIPOQ \| HMOX1 \| INS1 \| SLC2A4 \| TNF	17.68	9
44.	Rifampin	Liver Diseases	M	16 genes ABCB4 \| AHR \| ALPL \| BCL2L1 \| CCL2 \| CYP1A2 \| GPT \| HMOX1 \| INS \| NOS2 \| NR1H4 \| SERPINE1 \| SLCO1A1 \| SOCS3 \| SULT1E1 \| TNF	17.09	23
45.	Heme	Wounds and Injuries	M	5 genes CXCL2 \| HMOX1 \| IL6 \| MPO \| TNF	16.88	2
46.	tin protoporphyrin IX	Thrombosis	M	6 genes AGT \| CRP \| HMOX1 \| PTGS2 \| SERPINE1 \| TNF	16.80	8
47.	Vitamin B 12	Nervous System Diseases	M	10 genes ABCB1 \| ACHE \| BDNF \| CASP3 \| GFAP \| MTHFR \| NGF \| SERPINE1 \| SOD1 \| TNF	16.47	14
48.	zinc protoporphyrin	Hepatic Insufficiency	M	5 genes ALB \| NFE2L2 \| NOS2 \| RELA \| TGFB1	16.20	2
49.	Vitamin B 12	Liver Diseases	M	10 genes ABCB4 \| ACTA2 \| CCL2 \| HMOX1 \| MTHFR \| NQO1 \| SERPINE1 \| SOD1 \| SULT1E1 \| TNF	16.15	14
50.	Rifampin	Glomerulonephritis	M	10 genes CCL2 \| CCL5 \| FAS \| IFNG \| IL10 \| IL18 \| IL1B \| IL6 \| PPARG \| TNF	16.13	18

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