1. |
11-hydroxyprogesterone
|
regulation of metabolic process
|
Soot
|
[Soot affects regulation of metabolic process] which results in decreased abundance of 11-hydroxyprogesterone |
1: Rattus norvegicus |
Serum
|
|
1 |
2. |
11-hydroxyprogesterone 11-glucuronide
|
regulation of cellular metabolic process
|
deoxynivalenol
|
[deoxynivalenol affects regulation of cellular metabolic process] which results in decreased abundance of 11-hydroxyprogesterone 11-glucuronide |
1: Sus scrofa |
Intestinal Mucosa
| Cell Line
|
|
1 |
3. |
17,20-dihydroxy-4-pregnen-3-one
|
androgen receptor signaling pathway
|
|
17,20-dihydroxy-4-pregnen-3-one results in increased androgen receptor signaling pathway |
1: Gnathopogon caerulescens |
Sertoli Cells
|
|
1 |
4. |
17,20-dihydroxy-4-pregnen-3-one
|
steroid biosynthetic process
|
bisphenol A
|
[bisphenol A affects steroid biosynthetic process] which results in increased abundance of 17,20-dihydroxy-4-pregnen-3-one |
1: Sparus aurata |
Plasma
|
|
1 |
5. |
17-alpha-Hydroxyprogesterone
|
C21-steroid hormone metabolic process
|
Ketoconazole
|
[Ketoconazole affects C21-steroid hormone metabolic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line
|
1 gene
|
1 |
6. |
17-alpha-Hydroxyprogesterone
|
C21-steroid hormone metabolic process
|
Ketoconazole
|
[Ketoconazole affects C21-steroid hormone metabolic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
1 gene
|
1 |
7. |
17-alpha-Hydroxyprogesterone
|
C21-steroid hormone metabolic process
|
Fluconazole
|
[Fluconazole affects C21-steroid hormone metabolic process] which affects the abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
1 gene
|
1 |
8. |
17-alpha-Hydroxyprogesterone
|
C21-steroid hormone metabolic process
|
Fluconazole
|
[Fluconazole affects C21-steroid hormone metabolic process] which results in increased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line
|
1 gene
|
1 |
9. |
17-alpha-Hydroxyprogesterone
|
steroid biosynthetic process
|
Colforsin
|
[Colforsin results in increased steroid biosynthetic process] which results in increased secretion of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
3 genes
|
1 |
10. |
17-alpha-Hydroxyprogesterone
|
negative regulation of steroid hormone biosynthetic process
|
Venlafaxine Hydrochloride
|
[Venlafaxine Hydrochloride results in increased negative regulation of steroid hormone biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
11. |
17-alpha-Hydroxyprogesterone
|
negative regulation of steroid hormone biosynthetic process
|
Tramadol
|
[Tramadol results in increased negative regulation of steroid hormone biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
12. |
17-alpha-Hydroxyprogesterone
|
steroid biosynthetic process
|
Atorvastatin
|
[Atorvastatin results in decreased steroid biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
3 genes
|
1 |
13. |
17-alpha-Hydroxyprogesterone
|
steroid biosynthetic process
|
Atorvastatin
|
[Atorvastatin results in decreased steroid biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Rattus norvegicus |
Testis
|
3 genes
|
1 |
14. |
17-alpha-Hydroxyprogesterone
|
steroid biosynthetic process
|
Atorvastatin
|
[Atorvastatin results in decreased steroid biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Rattus norvegicus |
Adrenal Glands
|
3 genes
|
1 |
15. |
17-alpha-Hydroxyprogesterone
|
steroid biosynthetic process
|
Atorvastatin
|
[Atorvastatin results in decreased steroid biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Rattus norvegicus |
Plasma
|
3 genes
|
1 |
16. |
17-alpha-Hydroxyprogesterone
|
positive regulation of lipid storage
|
1-Methyl-3-isobutylxanthine
| Dexamethasone
| INS
| Rosiglitazone
|
17-alpha-Hydroxyprogesterone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased positive regulation of lipid storage] |
1: Homo sapiens |
Subcutaneous Fat
| Stem Cells
| Cells, Cultured
|
|
1 |
17. |
17-alpha-Hydroxyprogesterone
|
positive regulation of lipid storage
|
1-Methyl-3-isobutylxanthine
| INS
| Rosiglitazone
|
[17-alpha-Hydroxyprogesterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased positive regulation of lipid storage |
1: Homo sapiens |
Subcutaneous Fat
| Stem Cells
| Cells, Cultured
|
|
1 |
18. |
17-alpha-Hydroxyprogesterone
|
negative regulation of fat cell differentiation
|
1-Methyl-3-isobutylxanthine
| INS
| Rosiglitazone
|
[17-alpha-Hydroxyprogesterone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased negative regulation of fat cell differentiation |
1: Homo sapiens |
Subcutaneous Fat
| Stem Cells
| Cells, Cultured
|
2 genes
|
1 |
19. |
17-alpha-Hydroxyprogesterone
|
progesterone metabolic process
|
perfluorooctanoic acid
|
[perfluorooctanoic acid affects progesterone metabolic process] which affects the secretion of 17-alpha-Hydroxyprogesterone |
1: Mus musculus |
Leydig Cells
| Cell Line, Tumor
|
2 genes
|
1 |
20. |
17-alpha-Hydroxyprogesterone
|
positive regulation of steroid biosynthetic process
|
8-Bromo Cyclic Adenosine Monophosphate
|
[8-Bromo Cyclic Adenosine Monophosphate results in increased positive regulation of steroid biosynthetic process] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone |
1: Mus musculus |
Leydig Cells
| Cell Line
|
|
1 |
21. |
17-alpha-Hydroxyprogesterone
|
negative regulation of oxidoreductase activity
|
Clotrimazole
| CYP17A1
|
[[Clotrimazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of oxidoreductase activity] which results in decreased chemical synthesis of 17-alpha-Hydroxyprogesterone |
|
Cell-Free System
|
|
1 |
22. |
17-alpha-Hydroxyprogesterone
|
negative regulation of lyase activity
|
Clotrimazole
| CYP17A1
|
[[Clotrimazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of lyase activity] which results in increased metabolism of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
23. |
17-alpha-Hydroxyprogesterone
|
negative regulation of steroid hormone biosynthetic process
|
Clotrimazole
|
[Clotrimazole results in increased negative regulation of steroid hormone biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
24. |
17-alpha-Hydroxyprogesterone
|
negative regulation of oxidoreductase activity
|
CYP17A1
| Miconazole
|
[[Miconazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of oxidoreductase activity] which results in decreased chemical synthesis of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
25. |
17-alpha-Hydroxyprogesterone
|
negative regulation of oxidoreductase activity
|
CYP17A1
| Miconazole
|
[[Miconazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of oxidoreductase activity] which results in decreased chemical synthesis of 17-alpha-Hydroxyprogesterone |
|
Cell-Free System
|
|
1 |
26. |
17-alpha-Hydroxyprogesterone
|
negative regulation of lyase activity
|
CYP17A1
| Miconazole
|
[[Miconazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of lyase activity] which results in decreased metabolism of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
27. |
17-alpha-Hydroxyprogesterone
|
regulation of steroid hormone biosynthetic process
|
Miconazole
|
[Miconazole affects regulation of steroid hormone biosynthetic process] which results in increased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
28. |
17-alpha-Hydroxyprogesterone
|
negative regulation of oxidoreductase activity
|
CYP17A1
| Ketoconazole
|
[[Ketoconazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of oxidoreductase activity] which results in decreased chemical synthesis of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
29. |
17-alpha-Hydroxyprogesterone
|
negative regulation of oxidoreductase activity
|
CYP17A1
| Ketoconazole
|
[[Ketoconazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of oxidoreductase activity] which results in decreased chemical synthesis of 17-alpha-Hydroxyprogesterone |
|
Cell-Free System
|
|
1 |
30. |
17-alpha-Hydroxyprogesterone
|
negative regulation of lyase activity
|
CYP17A1
| Ketoconazole
|
[[Ketoconazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of lyase activity] which results in decreased metabolism of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
31. |
17-alpha-Hydroxyprogesterone
|
regulation of steroid hormone biosynthetic process
|
Ketoconazole
|
[Ketoconazole affects regulation of steroid hormone biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
32. |
17-alpha-Hydroxyprogesterone
|
positive regulation of oxidoreductase activity
|
CYP17A1
| Fluconazole
|
[[Fluconazole affects the activity of CYP17A1 protein] which results in increased positive regulation of oxidoreductase activity] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
33. |
17-alpha-Hydroxyprogesterone
|
negative regulation of lyase activity
|
CYP17A1
| Fluconazole
|
[[Fluconazole affects the activity of CYP17A1 protein] which results in increased negative regulation of lyase activity] which results in decreased metabolism of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
34. |
17-alpha-Hydroxyprogesterone
|
negative regulation of oxidoreductase activity
|
CYP17A1
| Fluconazole
|
[[Fluconazole results in decreased activity of CYP17A1 protein] which results in increased negative regulation of oxidoreductase activity] which results in decreased chemical synthesis of 17-alpha-Hydroxyprogesterone |
|
Cell-Free System
|
|
1 |
35. |
17-alpha-Hydroxyprogesterone
|
regulation of steroid hormone biosynthetic process
|
Fluconazole
|
[Fluconazole affects regulation of steroid hormone biosynthetic process] which results in increased abundance of 17-alpha-Hydroxyprogesterone |
1: Homo sapiens |
Adrenal Cortex
| Cell Line, Tumor
|
|
1 |
36. |
17-alpha-Hydroxyprogesterone
|
negative regulation of oxidoreductase activity
|
abiraterone
| CYP17A1
|
[[abiraterone results in decreased activity of CYP17A1 protein] which results in increased negative regulation of oxidoreductase activity] which results in decreased chemical synthesis of 17-alpha-Hydroxyprogesterone |
|
Cell-Free System
|
|
1 |
37. |
17-alpha-Hydroxyprogesterone
|
steroid biosynthetic process
|
Ketoconazole
|
[Ketoconazole affects steroid biosynthetic process] which results in decreased abundance of 17-alpha-Hydroxyprogesterone |
1: Macaca fascicularis |
Blood
|
3 genes
|
1 |
38. |
17-alpha-Hydroxyprogesterone
|
steroid biosynthetic process
|
Metyrapone
|
[Metyrapone affects steroid biosynthetic process] which results in increased abundance of 17-alpha-Hydroxyprogesterone |
1: Macaca fascicularis |
Blood
|
3 genes
|
1 |
39. |
17 alpha-Hydroxyprogesterone Caproate
|
positive regulation of lipid storage
|
1-Methyl-3-isobutylxanthine
| Dexamethasone
| INS
| Rosiglitazone
|
17 alpha-Hydroxyprogesterone Caproate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased positive regulation of lipid storage] |
1: Homo sapiens |
Subcutaneous Fat
| Stem Cells
| Cells, Cultured
|
|
1 |
40. |
17 alpha-Hydroxyprogesterone Caproate
|
positive regulation of lipid storage
|
1-Methyl-3-isobutylxanthine
| INS
| Rosiglitazone
|
[17 alpha-Hydroxyprogesterone Caproate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased positive regulation of lipid storage |
1: Homo sapiens |
Subcutaneous Fat
| Stem Cells
| Cells, Cultured
|
|
1 |
41. |
17 alpha-Hydroxyprogesterone Caproate
|
negative regulation of fat cell differentiation
|
1-Methyl-3-isobutylxanthine
| INS
| Rosiglitazone
|
[17 alpha-Hydroxyprogesterone Caproate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased negative regulation of fat cell differentiation |
1: Homo sapiens |
Subcutaneous Fat
| Stem Cells
| Cells, Cultured
|
3 genes
|
1 |
42. |
7-hydroxyprogesterone
|
progesterone secretion
|
Sodium Glutamate
|
[Sodium Glutamate results in decreased progesterone secretion] which results in decreased abundance of 7-hydroxyprogesterone |
1: Rattus norvegicus |
Leydig Cells
|
|
1 |
43. |
Medroxyprogesterone
|
spermatogenesis
|
Testosterone
|
[Medroxyprogesterone co-treated with Testosterone] results in decreased spermatogenesis |
1: Homo sapiens |
Testis
|
2 genes
|
1 |
44. |
Medroxyprogesterone
|
metabolic process
|
2-chloroethyl ethyl sulfide
|
[2-chloroethyl ethyl sulfide affects metabolic process] which results in increased abundance of Medroxyprogesterone |
1: Mus musculus |
Plasma
|
|
1 |
45. |
Medroxyprogesterone Acetate
|
MAPK cascade
|
|
Medroxyprogesterone Acetate results in increased MAPK cascade |
1: Mus musculus |
Mammary Glands, Animal
| Tumor Cells, Cultured
|
9 genes
|
1 |
46. |
Medroxyprogesterone Acetate
|
cell population proliferation
|
Mifepristone
|
Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased cell population proliferation] |
1: Mus musculus |
Mammary Glands, Animal
| Tumor Cells, Cultured
|
19 genes
|
1 |
47. |
Medroxyprogesterone Acetate
|
cell population proliferation
|
|
Medroxyprogesterone Acetate results in increased cell population proliferation |
1: Mus musculus |
Mammary Glands, Animal
| Tumor Cells, Cultured
|
19 genes
|
1 |
48. |
Medroxyprogesterone Acetate
|
apoptotic process
|
Bezafibrate
|
[Bezafibrate co-treated with Medroxyprogesterone Acetate] results in increased apoptotic process |
1: Homo sapiens |
Lymphocytes
| Tumor Cells, Cultured
|
35 genes
|
1 |
49. |
Medroxyprogesterone Acetate
|
apoptotic process
|
Bezafibrate
| CD40LG
|
CD40LG protein inhibits the reaction [[Bezafibrate co-treated with Medroxyprogesterone Acetate] results in increased apoptotic process] |
1: Homo sapiens |
Lymphocytes
| Tumor Cells, Cultured
|
35 genes
|
1 |
50. |
Medroxyprogesterone Acetate
|
apoptotic process
|
Bezafibrate
| CD40LG
| lycorine
|
lycorine inhibits the reaction [CD40LG protein inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Bezafibrate] results in increased apoptotic process]] |
1: Homo sapiens |
Lymphocytes
| Tumor Cells, Cultured
|
35 genes
|
1 |