Hydroxyprogesterones - Diseases

These diseases are associated with Hydroxyprogesterones or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 2,121 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Medroxyprogesterone Acetate	Adenocarcinoma	M	24 genes AZGP1 \| CA2 \| CCN2 \| CCND1 \| CYP19A1 \| EFEMP1 \| ESR1 \| GPX3 \| HOXA10 \| IL1B \| KDR \| KRT8 \| NOS3 \| NR1I2 \| PGR \| PLAU \| PRL \| PTGS2 \| RELA \| SOD2 \| SPP1 \| TNF \| TP53 \| VEGFA	42.69	29
2.	Medroxyprogesterone Acetate	Myocardial Infarction	M	27 genes ADORA3 \| AGT \| ATP1A1 \| BAX \| CASP3 \| CAT \| CREM \| ESR1 \| F13A1 \| F2 \| F7 \| HSD11B2 \| ICAM1 \| IL1B \| IL6 \| LDHA \| LGALS3 \| MMP2 \| MMP9 \| NOS3 \| NR3C2 \| NRIP1 \| PLAT \| PLAU \| SOD1 \| SOD2 \| TNF	39.08	67
3.	Medroxyprogesterone Acetate	Chemical and Drug Induced Liver Injury	M	49 genes ACSL1 \| AGT \| AHR \| ANXA2 \| BAX \| C3 \| CAT \| CCL2 \| CRP \| CYP1A1 \| CYP1B1 \| CYP3A4 \| EPHX1 \| F3 \| FADS2 \| GADD45A \| GSN \| GSTM3 \| IFNG \| IL11 \| IL12B \| IL1B \| IL6 \| KRT8 \| LCN2 \| LGALS3 \| MIR142 \| MIR193B \| MIR21 \| MIR27B \| MIR29C \| MIR625 \| MMP2 \| MMP9 \| NFE2L2 \| NR1I2 \| P4HB \| PLAT \| PLG \| PLS3 \| PTGS2 \| SEMA3A \| SOD1 \| SOD2 \| SPP1 \| THBS1 \| TNF \| VEGFA \| VIM	36.99	43
4.	Medroxyprogesterone Acetate	Mammary Neoplasms, Experimental	M	20 genes ACSL1 \| ALCAM \| CCND1 \| DES \| EEF1A1 \| EFEMP1 \| EPHX1 \| ESR1 \| FN1 \| MMP2 \| MMP9 \| NCOA1 \| PDGFA \| PGR \| PRL \| RAN \| SELENOP \| SGK1 \| SOD2 \| SPP1	32.18	15
5.	Medroxyprogesterone Acetate	Mammary Neoplasms, Animal	M	16 genes ACSL1 \| ALCAM \| ANXA2 \| CCND1 \| DES \| EEF1A1 \| EFEMP1 \| EPHX1 \| ESR1 \| FN1 \| PDGFA \| PGR \| PRL \| RAN \| SELENOP \| SGK1	28.40	10
6.	Medroxyprogesterone Acetate	Thrombosis	M	13 genes AGT \| CRP \| F2 \| F3 \| F9 \| KLF4 \| PLAT \| PLAU \| PTGS2 \| SERPINC1 \| SERPINE1 \| SIRT1 \| TNF	18.78	25
7.	Medroxyprogesterone Acetate	Venous Thrombosis	M	10 genes F13A1 \| F2 \| F3 \| F7 \| KDR \| PLAT \| PLAU \| PLG \| SERPINC1 \| TFPI	17.62	18
8.	17 alpha-Hydroxyprogesterone Caproate	Infertility, Male	M	5 genes AR \| ESR1 \| FSHB \| LHB \| TSC22D3	16.02	11
9.	Medroxyprogesterone Acetate	Stroke	M	10 genes F2 \| ICAM1 \| IL1B \| IL6 \| PLAT \| PLAU \| PTGS2 \| SMOX \| SOD1 \| TNF	14.30	69
10.	Medroxyprogesterone Acetate	Weight Gain	M	14 genes AHR \| AKR1C2 \| ANXA2 \| BCAT1 \| CALM1 \| CNR1 \| CTSD \| EZH2 \| GSN \| IDO1 \| IGFBP5 \| MMP2 \| TNF \| VIM	14.19	11
11.	Medroxyprogesterone Acetate	Fatty Liver	M	13 genes CAT \| CCL2 \| CYP19A1 \| CYP1B1 \| F2 \| F2R \| NFE2L2 \| NR1I2 \| SERPINE1 \| SIRT1 \| SOD1 \| SOD2 \| TNF	12.30	18
12.	17 alpha-Hydroxyprogesterone Caproate	Liver Cirrhosis, Experimental	M	6 genes ADIPOQ \| EDN1 \| IL1B \| INS \| PRLR \| TNF	10.23	6
13.	Medroxyprogesterone Acetate	Ventricular Dysfunction, Left	M	9 genes AGT \| CAST \| FAS \| IL6 \| NFE2L2 \| NR3C2 \| PLAT \| SIRT1 \| SOD2	10.19	11
14.	17 alpha-Hydroxyprogesterone Caproate	Diabetes, Gestational	M	2 genes ADIPOQ \| AR	8.28	3
15.	Medroxyprogesterone Acetate	Adenoma	M	6 genes ATP1A1 \| CYP1B1 \| GJA1 \| PRL \| SELENOP \| TP53	7.45	9
16.	Medroxyprogesterone Acetate	Amenorrhea	M	3 genes CYP19A1 \| FSHB \| PRL	7.27	5
17.	Medroxyprogesterone Acetate	Cardiovascular Diseases	M	7 genes AGT \| CCL2 \| CRP \| ICAM1 \| NOS3 \| PTGS2 \| VCAM1	6.28	10
18.	Medroxyprogesterone Acetate	Cleft Palate	M	4 genes FGF7 \| MTR \| NOS3 \| TGFB3	6.07	5
19.	Medroxyprogesterone Acetate	Carcinoma, Ductal, Breast	M	2 genes PTGS2 \| SOD2	4.96	3
20.	Medroxyprogesterone Acetate	Pulmonary Embolism	M	3 genes CAT \| PLAT \| PLAU	4.26	16
21.	Medroxyprogesterone Acetate	Respiratory System Abnormalities	M	1 gene TGFB3	4.03	2
22.	Medroxyprogesterone Acetate	Atrophy	M	3 genes AHR \| MAPK3 \| RPS6KB1	3.58	4
23.	Medroxyprogesterone Acetate	Heart Diseases	M	6 genes AGT \| CRP \| MIR21 \| SIRT1 \| SPP1 \| VEGFA	3.54	8
24.	Medroxyprogesterone	Adenocarcinoma	M	1 gene PGR	3.44	2
25.	Medroxyprogesterone	Mammary Neoplasms, Experimental	M	1 gene PGR	3.44	3
26.	Medroxyprogesterone Acetate	Depressive Disorder	M	6 genes CNR2 \| IL6 \| NPY1R \| NR3C1 \| PTGS2 \| SOD1	3.42	7
27.	Medroxyprogesterone Acetate	Tremor	M	1 gene HTR1A	3.40	2
28.	Medroxyprogesterone Acetate	Meningioma	M	1 gene PGR	3.30	4
29.	Medroxyprogesterone Acetate	Exanthema	M	1 gene C1QA	3.27	2
30.	17 alpha-Hydroxyprogesterone Caproate	Glucose Intolerance	M	1 gene INS	3.27	2
31.	Medroxyprogesterone Acetate	Fetal Resorption	M	1 gene PRL	3.21	2
32.	Medroxyprogesterone Acetate	Cognition Disorders	M	5 genes AGT \| CAPN2 \| CNR1 \| LAMB2 \| PTGS2	2.96	6
33.	Medroxyprogesterone Acetate	Carcinoma, Ductal	M	1 gene TP53	2.95	2
34.	Medroxyprogesterone Acetate	Coronary Disease	M	1 gene PLAU	2.91	4
35.	Medroxyprogesterone Acetate	Vomiting	M	1 gene IFNG	2.82	2
36.	Medroxyprogesterone Acetate	Fatigue	M	2 genes SOD1 \| TGFBR2	2.77	3
37.	Medroxyprogesterone Acetate	Genital Diseases, Male	M	1 gene AR	2.75	2
38.	Medroxyprogesterone Acetate	Mood Disorders	M	1 gene NR3C1	2.73	2
39.	Medroxyprogesterone	Myocardial Infarction	M	1 gene CAT	2.68	3
40.	17 alpha-Hydroxyprogesterone Caproate	Neoplasms, Experimental	M	1 gene TNF	2.20	4
41.	Medroxyprogesterone Acetate	Edema	M	6 genes CASP3 \| CAT \| IL11 \| IL6 \| PTGS2 \| TNF	2.19	4
42.	Medroxyprogesterone Acetate	Pain	M	6 genes BDKRB1 \| CNR1 \| HTR1A \| IL2 \| PENK \| TNF	2.14	9
43.	Medroxyprogesterone Acetate	Adrenal Cortex Diseases	M			1
44.	Medroxyprogesterone Acetate	Ataxia	M			1
45.	Medroxyprogesterone	Bladder Exstrophy	M			1
46.	Medroxyprogesterone Acetate	Cholelithiasis	M			1
47.	Medroxyprogesterone	Coronary Thrombosis	M			1
48.	Medroxyprogesterone Acetate	Cushing Syndrome	M			1
49.	Medroxyprogesterone Acetate	Deafness	M			1
50.	Medroxyprogesterone Acetate	Dementia	M			1

1–50 of 2,121 results.

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