Maria Bakalova was told live on set during a take by Judd Apatow that she had been nominated for an Academy Award for Best Supporting Actress in Borat Subsequent Moviefilm (2020).
During the promotional campaign that started on March 2, 2022, the film was initially advertised as "Cliff Beasts 6: The Battle for Everest: Memories of the Requiem". Even the official poster and the teaser trailer bore that title. The actual title was announced in the trailer that was released a few days later, and it was confirmed that "Cliff Beasts 6" was the film-within-the-film.
During the second quarantine, Dieter Bravo paints in the dark a copy of "Saturn devouring his son", one of the most famous paintings of Francisco de Goya. Goya painted it, along with another 13 paintings, directly onto the walls of his house, in a series called "Black Paintings" in the early 19th century. That series represents Goya's dark mood provoked by mental illness. All those paintings are now in the Museo del Prado in Madrid, Spain.
Leslie Mann and Iris Apatow are the wife and daughter of the film's director, Judd Apatow. The characters they play in the film are not biologically related to each other.