| Entry |
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| Name |
Aprindine (USAN/INN) |
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| Formula |
C22H30N2
|
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| Exact mass |
322.2409
|
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| Mol weight |
322.49
|
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01651 Class Ib antiarrhythmic agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
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| Remark |
| Product (DG00199): | D01326<JP> |
|
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| Efficacy |
Antiarrhythmic, Sodium channel blocker |
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| Target |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BB Antiarrhythmics, class Ib
C01BB04 Aprindine
D02969 Aprindine (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01651 Class Ib antiarrhythmic agent
DG00199 Aprindine
D02969 Aprindine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00199 Aprindine
D02969 Aprindine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D02969 Aprindine (USAN/INN)
SCN2A
D02969 Aprindine (USAN/INN)
SCN3A
D02969 Aprindine (USAN/INN)
SCN4A
D02969 Aprindine (USAN/INN)
SCN5A
D02969 Aprindine (USAN/INN)
SCN8A
D02969 Aprindine (USAN/INN)
SCN9A
D02969 Aprindine (USAN/INN)
SCN10A
D02969 Aprindine (USAN/INN)
SCN11A
D02969 Aprindine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02969
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01651 Class Ib antiarrhythmic agent
DG00199 Aprindine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00199 Aprindine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 24
1 N1c N 25.1001 -18.6544
2 C1b C 25.1001 -17.2521
3 C1b C 26.2920 -16.5510
4 C1b C 27.4839 -17.2521
5 N1c N 28.7459 -16.5510
6 C1b C 29.9378 -17.2521
7 C1a C 31.1297 -16.5510
8 C1b C 28.7459 -15.1488
9 C1a C 29.9378 -14.4477
10 C8y C 26.2920 -19.3555
11 C8x C 26.2920 -20.7577
12 C8x C 27.5540 -21.4589
13 C8x C 28.7459 -20.7577
14 C8x C 28.7459 -19.3555
15 C8x C 27.4839 -18.6544
16 C1y C 23.9220 -19.3277
17 C1x C 23.9160 -20.7198
18 C1x C 22.6000 -18.8917
19 C8y C 21.7768 -20.0144
20 C8y C 22.5901 -21.1442
21 C8x C 20.4875 -19.9974
22 C8x C 19.8018 -21.2879
23 C8x C 20.5119 -22.4853
24 C8x C 21.9118 -22.4689
BOND 26
1 2 3 1
2 6 7 1
3 10 11 2
4 11 12 1
5 12 13 2
6 13 14 1
7 14 15 2
8 15 10 1
9 5 8 1
10 3 4 1
11 8 9 1
12 1 2 1
13 1 10 1
14 4 5 1
15 5 6 1
16 1 16 1
17 16 17 1
18 16 18 1
19 18 19 1
20 19 20 1
21 17 20 1
22 19 21 2
23 21 22 1
24 22 23 2
25 23 24 1
26 20 24 2
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