Publication Name	World Journal of Psychiatry
Manuscript ID	91811
Country	India

Category	Psychiatry
Manuscript Type	Review
Article Title	Metabolic complications of psychotropic medications in psychiatric disorders: Emerging role of de novo lipogenesis and therapeutic consideration
Manuscript Source	Invited Manuscript
All Author List	Mohammad M Khan, Zaw Ali Khan and Mohsin Ali Khan
Funding Agency and Grant Number
Corresponding Author	Mohammad M Khan, PhD, Professor, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era’s Lucknow Medical College and Hospital, Faculty of Science, Era University, Sarfarazganj, Hardoi Road, Lucknow 226003, India. mmkhan0@gmail.com
Key Words	Psychotropic medications; Metabolic complications; De novo lipogenesis; Obesity; Diabetes; Non-alcoholic fatty liver disease
Core Tip	Psychotropic medications are the first line of treatment for psychiatric disorders; however, their long-term use has been shown to induce various metabolic abnormalities including diabetes, obesity, and fatty liver disease. Although mechanism(s) underlying these metabolic abnormalities is not clear, lipid/fatty acid accumulation caused by enhanced de novo lipogenesis (DNL) could be the primary mediator. In this regard, various anti-inflammatory drugs that are used in combination therapy, have been shown to reduce DNL and the aforementioned metabolic abnormalities in laboratory animals. This suggests that DNL could be a potential pathological and therapeutic target, and a new avenue for translational research in psychiatric disorders.
Citation	<p>Khan MM, Khan ZA, Khan MA. Metabolic complications of psychotropic medications in psychiatric disorders: Emerging role of de novo lipogenesis and therapeutic consideration. <i>World J Psychiatry</i> 2024; 14(6): 767-783</p>

Received	2024-01-06 00:46
Peer-Review Started	2024-01-06 00:46
To Make the First Decision
Return for Revision	2024-04-08 06:59
Revised	2024-05-05 20:08
Second Decision	2024-05-23 02:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-23 06:19
Articles in Press	2024-05-23 06:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-07 01:44

ISSN	2220-3206 (online)
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