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2020, Neurological Sciences
Neurology Research International
Neurological Components in Coronavirus Induced Disease: A Review of the Literature Related to SARS, MERS, and COVID-192020 •
Background. COVID-19 has been declared the pandemic of the 21st century, causing more than 45,000 deaths worldwide. The abrupt release of SARS-CoV-2 demonstrated the potential infection, morbidity, and lethality of zoonotic viruses and human-to-human transmission. Fever, cough, and fatigue are reported as the most common symptoms of the disease, including acute respiratory distress syndrome, and also signs of severe illness, such as shock, acute cardiac injury, and renal lesions, are described. Considering the previous works related to human coronavirus and other zoonotic infections, it has been demonstrated that the neuroinvasive propensity is a common characteristic of coronaviruses, especially in SARS-CoV and MERS-CoV. Objective. In the present review, we analyzed the potential neurological components involved in coronavirus infections and detailed the neurological syndromes related to COVID-19. We also examined the mechanism of transmission and CNS pathology related to other vir...
2020 •
BACKGROUND: The COVID-19 was declared like the pandemic of the 21st century and has caused more than 45 thousand deaths worldwide. The abrupt onset of SARS-CoV-2 demonstrated the potential infection, morbidity, and lethality of zoonotic viruses and the human-to-human transmission. The fever, cough, and fatigue are the most common symptoms of the disease and include too, acute respiratory distress syndrome, shock, acute cardiac injury, and acute renal injury between others signs in severe illness. Considered the previous work with human coronavirus and other zoonotic infections, the neuroinvasive propensity has been demonstrated as a common feature of coronaviruses, especially between SARS-CoV and MERS-CoV.OBJECTIVE: In the current review, we analyzed the possible neurological component in coronaviruses infections and detail neurologic syndrome related to COVID-19 disease. We review too, transmission mechanism and CNS pathology related to another virus with similar structures like SA...
Journal of Biosciences
Central nervous system as a target of novel coronavirus infections: Potential routes of entry and pathogenic mechanismsJournal of Molecular Neuroscience
Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System: A Review on Neurological Impairments and Manifestations2021 •
The coronavirus disease 2019 (COVID-19) pandemic is an issue of global significance that has taken the lives of many across the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for its pathogenesis. The pulmonary manifestations of COVID-19 have been well described in the literature. Initially, it was thought to be limited to the respiratory system; however, we now recognize that COVID-19 also affects several other organs, including the nervous system. Two similar human coronaviruses (CoV) that cause severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) are also known to cause disease in the nervous system. The neurological manifestations of SARS-CoV-2 infection are growing rapidly, as evidenced by several reports. There are several mechanisms responsible for such manifestations in the nervous system. For instance, post-infectious immune-mediated processes, direct virus infection of the central nervous system (CNS), and virus-induced hyperinflammatory and hypercoagulable states are commonly involved. Guillain-Barré syndrome (GBS) and its variants, dysfunction of taste and smell, and muscle injury are numerous examples of COVID-19 PNS (peripheral nervous system) disease. Likewise, hemorrhagic and ischemic stroke, encephalitis, meningitis, encephalopathy acute disseminated encephalomyelitis, endothelialitis, and venous sinus thrombosis are some instances of COVID-19 CNS disease. Due to multifactorial and complicated pathogenic mechanisms, COVID-19 poses a large-scale threat to the whole nervous system. A complete understanding of SARS-CoV-2 neurological impairments is still lacking, but our knowledge base is rapidly expanding. Therefore, we anticipate that this comprehensive review will provide valuable insights and facilitate the work of neuroscientists in unfolding different neurological dimensions of COVID-19 and other CoV associated abnormalities.
Current Treatment Options in Neurology
Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System2020 •
Acta Physiologica
Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID‐192020 •
Bosnian Journal of Basic Medical Sciences
SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease (COVID-19)The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is believed to have emerged from an animal source and has been spreading rapidly among humans. Recent evidence shows that SARS-CoV-2 exhibits neurotropic properties and causes neurological diseases. Here we review the literature on neurological involvement in SARS-CoV-2 infections and the possible mechanisms of invasion of the nervous system by this virus, to provide a summary and critical analysis of the early reporting of neurological involvement in COVID-19. An exhaustive search of scientific articles on neurological involvement in COVID-19 was performed in the Web of Science, Scopus, Medline/PubMed, and several other databases. Nineteen relevant articles that had been published or were in preprint were carefully selected according to the inclusion and exclusion criteria. Based on our research, we found that patients with COVID-19 can present with neu...
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Archeologia Medievale XVI
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EDUKASI: Jurnal Penelitian Pendidikan Agama dan Keagamaan
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Electricity Generation Potential and Energy Cost of Wind Conversion Systems in Ikeja Southwest Nigeria2020 •
Histochemistry and cell biology
Pattern of cardiotoxin-induced muscle remodeling in distinct TLR-4 deficient mouse strains2017 •
The Journal of Clinical Pharmacology
Pharmacokinetics of Para‐Aminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance2019 •
Manuscrítica: Revista de Crítica Genética
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