Browsing by FAS Department "Master of Medical Sciences in Biomedical Informatics"
Now showing items 1-19 of 19
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An Administrative Data Algorithm to Predict Inpatient Death at One Tertiary Cancer Center
(2020-10-30)Importance – Despite almost universal agreement that the end of life is a time during which medical care should be directed at alleviation of symptoms and provided at home if possible, one quarter to one half of age-eligible ... -
Assessing Population Based Differences of Average Total Depth of Coverage in Next Generation Sequencing
(2020-10-30)ABSTRACT Purpose. Next generation sequencing (NGS) is increasingly important to the development and advancement of Precision Medicine. However, there is limited data to support the establishment of a technical validation ... -
Association Between Genetic Variants and Clinical Features Among Sub-Classes of Migraine and Probable Migraine
(2017-06-19)Migraine is a prevalent and disabling neurological disease, characterized by substantial clinical heterogeneity. The current study examined 46 single nucleotide polymorphisms (SNPs) recently identified in a meta-analysis ... -
Circulating microRNAs and Both Association With Methacholine PC20 and Prediction of Asthma Exacerbation in the Childhood Asthma Management Program (CAMP) Cohort
(2017-06-19)Background: Circulating microRNAs have shown promise both as a non-invasive biomarker and a predictor of disease activity. Prior asthma studies with clinical, biochemical, or genomic tests have failed to demonstrate excellent ... -
Clinical Decision Support Rules Analysis: Methodology of Evaluating Success
(2016-08-01)In medicine there are several recommendations for routine monitoring. These exist both for medications commonly used by clinicians and for age relevant screening lab tests. Clinical informatics system use decision support ... -
DXplain Mobile: An Assessment of a Smartphone-Based Expert Diagnostic System
(2016-07-27)Objectives: Clinical decision support tools may help reduce diagnostic error, and improving the accessibility and usability of these tools may encourage more frequent use. We have developed a novel, self-contained, ... -
Genome-Wide Association Study Identifies New Genetic Determinants of Emphysema Distribution
(2016-07-27)Rationale: Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe predominant emphysema has emerged as an important predictor of response to lung ... -
Genome-Wide Identification and Characterization of Notch Transcriptional Complex-Binding Sequence Paired Sites in Leukemia Cells
(2016-07-27)Notch transcription complexes (NTCs) drive target gene expression by binding two distinct types of genomic response elements, NTC monomer sites and sequence-paired sites (SPSs) that bind NTC dimers. SPSs are conserved and ... -
Medical Subdomain Classification of Clinical Notes Using a Machine Learning-Based Natural Language Processing Approach
(2017-06-19)OBJECTIVE: The medical subdomain of a clinical note, such as cardiology or neurology, is useful content-derived metadata for developing machine learning downstream applications. To classify the medical subdomain of a note ... -
Opportunities for Innovation to Enhance the Image Ordering Process
(2016-07-27)Objectives: To quantify clinical concepts relevant to radiology consultation requests and assess rates of clinical decision support (CDS) attributes documented in Emergency Department provider notes at the time of image ... -
Optimization of Anticoagulation Therapy by Secondary Analysis of Clinical Trial Data
(2016-07-27)The objective of this thesis is conduct a secondary use of clinical data analysis using the ENGAGE clinical trial data set to calculate warfarin therapeutic dose for a large collection of clinical trial participants, and ... -
Overcoming Resistance in Patient-Derived Xenograft Models of BCR-ABL-Rearranged Acute Lymphoblastic Leukemia
(2016-07-27)The BCR-ABL fusion oncogene defines the most common molecular subtype of acute lymphoblastic leukemia in adults (BCR-ABL+ ALL) and has historically conferred an adverse prognosis. Incorporation of tyrosine kinase inhibitors ... -
Predicting Falls in People Aged 65 Years and Older From Insurance Claims
(2016-07-27)IMPORTANCE: Accidental falls among people aged 65 years and older caused approximately 2,700,000 injuries, 27,000 deaths, and cost more than 34 billion dollars in the United States annually in recent years. OBJECTIVE: To ... -
Race-Specific Differential DNA Methylation Marks and Gene Comethylation Modules of COPD
(2016-07-27)Rationale: Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death worldwide. Identifying COPD-associated DNA methylation marks in African-Americans may contribute to our understanding of racial ... -
Rethinking the Outpatient Medication List: Increasing Patient Activation and Education While Architecting for Centralization and Improved Medication Reconciliation.
(2017-06-30)An effective means to achieve an accurate, up-to-date medication list for patients cared for in multiple clinical institutions and care circumstances have yet to be developed. Research thus far has focused on approaches ... -
Role of Copy-Number Variations in Non-Coding Regions of Autism Spectrum Disorders
(2017-06-27)Autism Spectrum Disorders have a strong genetic basis. So far, only a small fraction of affected individuals has been linked to a certain genetic risk factor. Previous genetic studies focused on analyses of the protein-coding ... -
Site Enrollment Success: Mixed Methods Evaluation and Modeling of an FDA-Approved Phase III Chronic Obstructive Pulmonary Disease Trial
(2017-06-30)The United States (U.S.) FDA mandates the use of multi-phase clinical trials to elucidate important information on drug safety and efficacy prior to approval and marketing. Since the Kefauver-Harris Drug Amendments of 1962, ... -
Spt5 Regulates Sense and Antisense Transcription Genome-Wide
(2016-07-27)Spt5 is the only transcription elongation factor conserved in all three domains of life, but its molecular mechanisms are not yet thoroughly studied genomically. From an inducible depletion strain, we sequenced nascent ... -
Usage Patterns of a Mobile Palliative Care Just-in-Time Educational Tool
(2017-06-27)Background: Fast Facts Mobile (FFM) was created to be a convenient way for clinicians to access the Fast Facts and Concepts database of palliative care articles on a smartphone or tablet device. We analyzed usage patterns ...