Drug Notices

There is currently a national drug shortage of
National drug shortages that have resolved
  • For information on all current and resolved drug shortages and discontinuations reported to the U.S. Food & Drug Administration (FDA), please visit the FDA’s Drug Shortages page.
  • Notify DSTDP (stdshortages@cdc.gov) of any shortage or low inventories of STI treatments in your jurisdiction so CDC can continue monitoring treatment availability.
Bicillin L-A® Shortage

The FDA has listed penicillin G benzathine injectable suspension products (Bicillin L-A®) on their drug shortage webpage, noting limited supply due to increased demand. The FDA website includes an expected duration for the shortage. CDC continues to monitor the situation and will post updates as needed.

Bicillin L-A® is the first-line recommended treatment for syphilis and the only recommended treatment option for some patients.

During this time, programs should:

  • Continue to follow CDC’s treatment recommendations. Penicillin G benzathine (Bicillin L-A®) is the only recommended treatment for pregnant people infected with or exposed to syphilis.
    • Doxycycline 100mg PO BID for two weeks (for early syphilis) or for four weeks (for late latent or syphilis of unknown duration) is an alternative for the treatment of non-pregnant people with a penicillin allergy.
  • Prioritize the use of Bicillin L-A® to treat pregnant people and babies with congenital syphilis.
  • To help CDC continue to monitor the situation, notify DSTDP (stdshortages@cdc.gov) of:
    • Shortages or stock-outs of Bicillin L-A® in the jurisdiction.
    • Situations in which patients diagnosed with syphilis are not being treated due to the inability to procure Bicillin L-A® in the jurisdiction.
  • Report any shortages to the Pfizer Supply Continuity Team at 844-646-4398 (select 1 and then select 3).
STI Drug Availability as of July 29, 2022
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FDA Drug Shortage List Availability Manufacturers *
Azithromycin
No
  • Several manufacturers
  • Shortage resolved as of 12/30/2020
  • Alembic Pharmaceutical
    908-393-9604
  • Aurobindo Pharma
    732-839-9400
  • Biopharma Inc.
    888-611-2466
  • CSPC Ouyi Pharmaceutical Co. Ltd.
    609-356-0210
  • HEC Pharm USA Inc.
    267-348-3664
  • Lupin Pharmaceuticals Inc
    866-587-4617
  • Pfizer
    800-533-4535
  • Sandoz
    800-525-8747
  • Teva Pharmaceuticals
    800-545-8800
  • Wockhardt USA LLC
    800-346-6859
FDA Drug Shortage List Availability Manufacturers *
Benzathine penicillin
No
  • One manufacturer: Pfizer
  • No supply issues
  • Pfizer
    800-533-4535
FDA Drug Shortage List Availability Manufacturers *
Cefixime1
Yes (as of 1/21/2022)
  • Two manufacturers:  Alkem/Ascend and Lupin
  • See FDA drug shortage website for current availability
  • Alkem/Ascend
    201-476-1977
  • Lupin Pharmaceuticals Inc
    866-587-4617
FDA Drug Shortage List Availability Manufacturers *
Ceftriaxone2
No
  • Several manufacturers
  • No supply issues
  • A-S Medication Solutions
    877-863-3228
  • Apotex Corp
    800-706-5575
  • Hospira, Inc
    844-646-4398
  • Lupin Pharmaceuticals Inc
    866-587-4617
  • NuCare Pharmaceuticals Inc
    888-482-9545
  • Piramal Critical Care Inc
    800-414-1901
  • Proficient Rx LP
    877-717-2714
  • Remedy Repack Inc
    866-845-3791
  • Sagent Pharmaceutical
    866-625-1618
  • Sandoz Inc
    800-525-8747
  • West-Ward Pharm Corp (Hikma)
    732-542-1191
  • WG Critical Care LLC
    888-493-0861
  • Wockhardt USA LLC
    800-346-6854
FDA Drug Shortage List Availability Manufacturers *
Doxycycline3
No
  • Several manufacturers
  • No supply issues
  • Aqua Pharmaceuticals Inc
  • Aimirall, Lic
    610-644-7000
  • Ajanta Pharma LTD
    866-770-3029
  • A-S Medication Solutions
    877-863-3228
  • Alembic Pharmaceutical Inc
    908-393-9604
  • Alvogen Inc
    alvogen.com
  • American Health Packaging
    800-707-4621
  • Amneal Pharmaceuticals of NY Inc
    908-947-3120
  • AvPAK
    855-361-3993
  • AvKare, Inc
    855-628-5273
  • Bi-Coastal Pharm
    732-530-3900
  • Bryant Ranch Prepack
    877-885-0882
  • Cadila Pharmaceuticals LTD
    202-355-9784
  • Cambridge Therapeutics Technologies, LLC
    844-810-0004
  • Cardinal Health
    800-926-3161
  • Chatwell Rx LLC
    833-242-7879
  • Changzhou Pharm
  • Contract Pharmacy Service
    800-555-8062
  • Cosette Pharmaceuticals
    800-922-1038
  • Denton Pharma Inc
    518-827-7750
  • Direct Rx
    855-362-3397
  • Epic
    888-374-2791
  • Golden State Medical Supply
    800-284-¬8633
  • Harris Pharm Inc
    877-794-3376
  • Heritage Pharmaceutical Inc
    678-782-5702
  • Hikma Pharmaceuticals Inc
    800-631-2174
  • Lake Erie Medical &Surgical Supply DBA Quality Care Products LLC
  • Lannett Company Inc
    215-333-9000
  • Liberty Pharmaceutical Inc
    951-427-5416
  • Lupin Pharmaceutical
    866-587-4617
  • Major Pharmaceutical
    800-616-2471
  • McKesson Corp
    800-571-2889
  • Medsource Pharmaceuticals
    888-612-1965
  • Mylan Pharmaceuticals Inc
    724-514-1800
  • Novel Lab Inc
    908-603-6000
  • NuCare Pharmaceutical Inc
    888-482-9545
  • Oaklock LLC
    601-855-7678
  • ParPham Inc
    parpharm.com
  • Pfizer
    800-533-4535
  • PD-Rx Pharmaceutical Inc
    800-299-7379
  • PharmPak, Inc
    800-541-6315
  • Preferred Pharmaceutical Inc
    714-777-3729
  • Proficient Rx LP
    800-787-7824
  • Puracap Laboratories
    908-941-5456
  • RedPharm Drug Inc
    952- 653-2525
  • Remedy RePack
    866-845-3791
  • St. Mary’s Medical Park
    520-297-3800
  • Sun Pharmaceuticals Ind Inc
    866-931-0704
  • UniChem Pharmaceutical Inc
    888-304-5022
  • Viona Pharmaceutical Inc
    800-818-4555
  • Westward Pharma Corp
    866-931-0704
  • Zylan Pharmaceuticals
    800-631-2174
  • Zyduis Pharmaceuticals Inc
    609-730-1900
FDA Drug Shortage List Availability Manufacturers *
Erythromycin (0.5%) ophthalmic ointment4
Yes
(as of 7/6/2022)
  • Three manufacturers
  • See FDA drug shortage website for current availability
  • Akron Pharmaceuticals
    800-932-5676
  • Bausch Health
    800-321-4576
  • Perriago Company PLC
    269-673-8451
FDA Drug Shortage List Availability Manufacturers *
Gentamicin5
Yes
(as of 7/23/2021)
  • Two main manufacturers: Pfizer and Fresenius Kabi US
  • See FDA drug shortage website for current availability
  • Fresenius Kabi USA
    888-386-1300
  • Hospira, Inc.
    844-646-4398
FDA Drug Shortage List Availability Manufacturers *
Lidocaine6
Yes
(as of 2/22/2012)
  • Several manufacturers
  • Product availability based on manufacturer
  • See FDA drug shortage website for current availability
  • American Regent/Luitpoid
    800-645-1706
  • Amphastar Pharmaceuticals, Inc/IMS
    800-423-4136
  • AuroMedica Parma LLC
    888-238-1880
  • Fresenius Kabi USA
    888-386-1300
  • Hikma Pharma
    800-631-2174
  • Hospira Inc
    844-646-4398
  • Spectra Medical Devices Inc
    978-657-0889 x5231
FDA Drug Shortage List Availability Manufacturers *
Metronidazole7
No
  • Several manufacturers
  • No supply issues
  • A-S Medication Solutions
    877-863-3228
  • Alembic Pharmaceutical Inc
    908-393-9604
  • American Health Packaging
    800-707-4621
  • AMCI Pharmaceutical LLC
    631.396.0129
  • Aurobindo Pharmaceuticals LTD
    732-839-9400
  • AvPAK
    855-361-3993
  • Blue Point Laboratories
    800-707-4621
  • Bryant Ranch Prepack
    877-885-0882
  • Cadila Pharmaceuticals LTD
    202-355-9784
  • Cambridge Therapeutics Technologies, LLC
    844-810-0004
  • Cardinal Health
    800-926-3161
  • Cosette Pharmaceuticals
    800-922-1038
  • Denta Pharma Inc
    dentapharma.com
  • Direct Rx
    855-362-3397
  • Golden State Medical Supply
    800-284-¬8633
  • Heritage Pharmaceutical Inc
    678-782-5702
  • Lake Erie Medical &Surgical Supply DBA Quality Care Products LLC*
  • Major Pharmaceutical
    800-616-2471
  • Medsource Pharmaceuticals
    888-612-1965
  • NuCare Pharmaceutical Inc
    888-482-9545
  • ORIT Lab LLC
    973-226-3700
  • PD-Rx Pharmaceutical Inc
    800-299-7379
  • PharmPak, Inc
    800-541-6315
  • Preferred Pharmaceutical Inc
    714-777-3729
  • Proficient Rx LP
    800-787-7824
  • RedPharm Drug Inc
    952- 653-2525
  • Remedy RePack
    866.845.3791
  • Rising Pharmaceutical Inc
    201-961-9000
  • St. Mary Medical Park
    520-297-3800
  • Strides Pharma Science LTD
    609-773-5000
  • Teva Pharmaceuticals US Inc
    800-545-8800
  • UniChem Pharmaceutical Inc
    866-931-0704
  • Viona Pharmaceutical Inc
    888-304-5022