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Evolutionary change in gene expression is generally considered to be a major driver
of phenotypic differences between species. We investigated innate immune diversification
by analyzing interspecies differences in the transcriptional responses of primary
...Author SummaryFig. P1.Typical gene, profile, and promoter characteristics associated with interspecies mRNA
regulatory divergence in innate immunity. Interspecies divergence in mRNA regulation
following immune stimulation was analyzed by using a custom-...
Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting
protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase domain-like protein
(MLKL), which results in disruption of the plasma membrane. Necroptotic cell lysis,...
The immune system must be able to respond to a myriad of different threats, each requiring
a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase
HDAC7 in macrophages is a metabolic switch that triages danger signals to ...