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The only known volatile pheromone in Drosophila, 11-cis-vaccenyl acetate (cVA), mediates a variety of behaviors including aggregation, mate
recognition, and sexual behavior. cVA is detected by a small set of olfactory neurons
located in T1 trichoid ...
Δ9-Tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct
cannabinoid receptor (CB1) agonists produce a number of neurobehavioral effects in
mammals that range from the beneficial (analgesia) to the untoward (abuse potential)...
Surveying genome-wide coding variation within and among species gives unprecedented
power to study the genetics of adaptation, in particular the proportion of amino acid
substitutions fixed by positive selection. Additionally, contrasting the autosomes
...
In Drosophila melanogaster, the male-specific pheromone cVA (11-cis-vaccenyl acetate) functions as a sex-specific social cue. However, our understanding
of the molecular mechanisms underlying cVA pheromone transduction and its regulation
are incomplete. ...
Materials that can serve as long-lived barriers to biofluids are essential to the
development of any type of chronic electronic implant. Devices such as cardiac pacemakers
and cochlear implants use bulk metal or ceramic packages as hermetic enclosures for
...
The Warburg effect, characterized by increased glucose uptake and lactate production,
is a well-known universal across cancer cells and other proliferating cells. PKM2,
a splice isoform of the pyruvate kinase (PK) specifically expressed in these cells,
...
Flexible biocompatible electronic systems that leverage key materials and manufacturing
techniques associated with the consumer electronics industry have potential for broad
applications in biomedicine and biological research. This study reports scalable ...
Inducible regulatory T (iTreg) cells play a crucial role in immune suppression and
are important for the maintenance of immune homeostasis. Mounting evidence has demonstrated
connections between iTreg differentiation and metabolic reprogramming, ...
Loss-of-function mutations in Angiopoietin-like 3 (Angptl3) are associated with lowered blood lipid levels, making Angptl3 an attractive therapeutic target for the treatment of human lipoprotein metabolism
disorders. In this study, we developed a lipid ...