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The adult human distal gut microbial community is typically dominated by 2 bacterial
phyla (divisions), the Firmicutes and the Bacteroidetes. Little is known about the
factors that govern the interactions between their members. Here, we examine the niches
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The ongoing revolution in high-throughput sequencing continues to democratize the
ability of small groups of investigators to map the microbial component of the biosphere.
In particular, the coevolution of new sequencing platforms and new software tools
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We deeply sampled the organismal, genetic, and transcriptional diversity in fecal
samples collected from a monozygotic (MZ) twin pair and compared the results to 1,095
communities from the gut and other body habitats of related and unrelated individuals.
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The human microbiome plays a key role in a wide range of host-related processes and
has a profound effect on human health. Comparative analyses of the human microbiome
have revealed substantial variation in species and gene composition associated with
a ...
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives
Food and drug products contain diverse and abundant small-molecule additives (excipients)
with unclear impacts on human physiology, drug safety, and response. Here, we evaluate
their potential impact on intestinal drug absorption. By screening 136 unique ...
Disease tolerance, the capacity of tissues to withstand damage caused by a stimulus
without a decline in host fitness, varies across tissues, environmental conditions,
and physiologic states. While disease tolerance is a known strategy of host defense,
...