Overview
DHEA is made by the adrenal glands and by the liver. DHEA levels seem to go down as people get older. DHEA levels seem to be lower in people with depression and after menopause.
People commonly use prescription DHEA for vaginal tissue thinning. DHEA supplements are used for aging skin, depression, infertility, muscle strength, heart disease, erectile dysfunction (ED), and many other conditions, but there is no good scientific evidence to support many of these other uses.
DHEA is banned by the National Collegiate Athletic Association (NCAA), the International Olympic Committee, and the World Anti-Doping Agency (WADA). Don't confuse DHEA with 7-alpha-hydroxy-DHEA, 7-beta-hydroxy-DHEA, and 7-keto-DHEA. These are all different forms of DHEA but are not the same as DHEA.
Uses & Effectiveness ?
Likely Effective for
- Thinning of vaginal tissue (vaginal atrophy). Using vaginal inserts containing DHEA can reduce pain during sex by up to 15% after menopause. A prescription DHEA product is available for this condition.
Possibly Effective for
- Aging skin. Taking DHEA by mouth or applying it to the skin might improve skin appearance after menopause and in people over the age of 60 years.
- Depression. Taking 30-500 mg of DHEA by mouth daily seems to improve symptoms of depression. Lower doses don't seem to help.
- Inability to become pregnant within a year of trying to conceive (infertility). Taking DHEA by mouth before in-vitro fertilization (IVF) might improve the chances of pregnancy and having a baby. But it's not clear if taking DHEA helps prevent miscarriage after IVF.
Possibly Ineffective for
- Aging. Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels.
- Muscle strength. Taking DHEA by mouth doesn't improve muscle strength in adults.
- Physical performance in elderly adults. Taking DHEA by mouth doesn't improve physical performance in older adults.
Likely InEffective for
- Memory and thinking skills (cognitive function). Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults.
- An autoimmune disorder in which the glands that produce tears and saliva are damaged (Sjogren syndrome). Taking DHEA by mouth does not improve symptoms of this condition.
Side Effects
DHEA is possibly unsafe when used in high doses or long-term. Do not use DHEA in doses higher than 50-100 mg daily or for a long period of time. Using higher doses or using it long-term can increase the risk of serious side effects including cancer.
When applied to the skin: DHEA is possibly safe when used appropriately. DHEA cream has been used safely for up to 1 year.
When applied into the vagina: DHEA is possibly safe when used appropriately. DHEA vaginal inserts have been safely used for up to 3 months.
Special Precautions and Warnings
DHEA is possibly unsafe when used in high doses or long-term. Do not use DHEA in doses higher than 50-100 mg daily or for a long period of time. Using higher doses or using it long-term can increase the risk of serious side effects including cancer.
When applied to the skin: DHEA is possibly safe when used appropriately. DHEA cream has been used safely for up to 1 year.
When applied into the vagina: DHEA is possibly safe when used appropriately. DHEA vaginal inserts have been safely used for up to 3 months. Pregnancy and breast-feeding: DHEA is possibly unsafe when taken during pregnancy or breast-feeding. It can cause higher than normal levels of a male hormone called androgen. This might be harmful to the baby. Do not use DHEA if you are pregnant or breast-feeding.
Diabetes: DHEA can affect how insulin works in the body. If you have diabetes, monitor your blood sugar carefully if you are taking DHEA.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: DHEA is a hormone that can affect how estrogen works in the body. If you have any condition that might be made worse by estrogen, do not use DHEA.
High cholesterol: DHEA might lower high-density lipoprotein (HDL or "good") cholesterol, especially in females. If you have high cholesterol or heart disease, talk with your healthcare provider before taking DHEA.
Liver problems: DHEA might make liver problems worse. Do not use DHEA if you have liver problems.
Depression and mood disorders: DHEA might cause excitability, impulsiveness, and irritability in people with mood disorders. If you have a mood disorder, talk to your healthcare provider before taking DHEA.
Polycystic ovary syndrome (PCOS): Taking DHEA might make this condition worse. Don't use DHEA if you have PCOS.
Interactions ?
Medications for estrogen sensitive cancers (Aromatase inhibitors) interacts with DHEA
The body changes DHEA to estrogen in the body. Aromatase inhibitors are used to help lower estrogen levels in the body. Taking DHEA might decrease the effects of aromatase inhibitors.
Fulvestrant (Faslodex) interacts with DHEA
Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Fulvestrant is used for these types of cancer. DHEA might increase estrogen in the body and decrease the effects of fulvestrant for treating cancer. Do not take DHEA if you are taking fulvestrant.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with DHEA
Some medications are changed and broken down by the liver. DHEA might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Tamoxifen (Nolvadex) interacts with DHEA
Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen is used to help treat and prevent these types of cancer. DHEA increases estrogen levels in the body and might decrease the effects of tamoxifen. Do not take DHEA if you are taking tamoxifen.
Triazolam (Halcion) interacts with DHEA
DHEA might decrease how quickly the body breaks down triazolam. Taking DHEA with triazolam might increase the effects and side effects of triazolam.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DHEA
DHEA might slow blood clotting. Taking DHEA along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications for depression (Antidepressant drugs) interacts with DHEA
There is some concern that taking DHEA along with antidepressant drugs might increase the risk for serious side effects. Speak with a healthcare provider before taking DHEA if you are taking an antidepressant.
Tuberculosis Vaccine interacts with DHEA
Taking DHEA might reduce the effects of the tuberculosis vaccine. Do not take DHEA if you are receiving a tuberculosis vaccine.
Moderate Interaction
Be cautious with this combination
Estrogens interacts with DHEA
DHEA might increase estrogen levels in the body. Taking DHEA along with estrogen might cause too much estrogen in the body.
Testosterone interacts with DHEA
Taking DHEA with testosterone might cause there to be too much testosterone in the body. This might increase the effects and side effects of testosterone.
Minor Interaction
Be watchful with this combination
Dosing
Orner, G. A., Mathews, C., Hendricks, J. D., Carpenter, H. M., Bailey, G. S., and Williams, D. E. Dehydroepiandrosterone is a complete hepatocarcinogen and potent tumor promoter in the absence of peroxisome proliferation in rainbow trout. Carcinogenesis 1995;16(12):2893-2898. View abstract.
Osmanagaoglu, M. A., Okumus, B., Osmanagaoglu, T., and Bozkaya, H. The relationship between serum dehydroepiandrosterone sulfate concentration and bone mineral density, lipids, and hormone replacement therapy in premenopausal and postmenopausal women. J Womens Health (Larchmt.) 2004;13(9):993-999. View abstract.
Ovsiukova, M. V., Obut, T. A., and Saryg, S. K. [The dehydroepiandrosterone sulfate influence on anxiety and depressive behaviour: participation of mu-opioid receptors]. Ross.Fiziol.Zh.Im I.M.Sechenova 2011;97(9):903-913. View abstract.
Page, J. H., Ma, J., Rexrode, K. M., Rifai, N., Manson, J. E., and Hankinson, S. E. Plasma dehydroepiandrosterone and risk of myocardial infarction in women. Clin Chem 2008;54(7):1190-1196. View abstract.
Panjari, M., Bell, R. J., Jane, F., Adams, J., Morrow, C., and Davis, S. R. The safety of 52 weeks of oral DHEA therapy for postmenopausal women. Maturitas 7-20-2009;63(3):240-245. View abstract.
Papierska, L., Rabijewski, M., Kasperlik-Zaluska, A., and Zgliczynski, W. Effect of DHEA supplementation on serum IGF-1, osteocalcin, and bone mineral density in postmenopausal, glucocorticoid-treated women. Adv.Med Sci 6-1-2012;57(1):51-57. View abstract.
Parker, C. R., Jr., Simpson, E. R., Bilheimer, D. W., Leveno, K., Carr, B. R., and MacDonald, P. C. Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma. Science 5-2-1980;208(4443):512-514. View abstract.
Patte-Mensah, C., Meyer, L., Kibaly, C., and Mensah-Nyagan, A. G. Regulatory effect of dehydroepiandrosterone on spinal cord nociceptive function. Front Biosci (Elite.Ed) 2010;2:1528-1537. View abstract.
Petri M, Lahita RG, McGuire J, and et al. Results of the GL701 (DHEA) multicenter steroid-sparing SLE study. Arthritis Rheum 1997;40(suppl):S327.
Phillips, A. C., Carroll, D., Gale, C. R., Lord, J. M., Arlt, W., and Batty, G. D. Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study. Eur J Endocrinol. 2010;163(2):285-292. View abstract.
Piedrola, G., Novo, E., Serrano-Gotarredona, J., de Teresa, M. L., Escobar-Jimenez, F., and Garcia-Robles, R. Relationship between insulin sensitivity and dehydroepiandrosterone sulfate in patients with ischemic heart disease. Horm.Metab Res 1997;29(11):566-571. View abstract.
Pluchino, N., Ninni, F., Stomati, M., Freschi, L., Casarosa, E., Valentino, V., Luisi, S., Genazzani, A. D., Poti, E., and Genazzani, A. R. One-year therapy with 10mg/day DHEA alone or in combination with HRT in postmenopausal women: effects on hormonal milieu. Maturitas 4-20-2008;59(4):293-303. View abstract.
Porola, P., Virkki, L., Przybyla, B. D., Laine, M., Patterson, T. A., Pihakari, A., and Konttinen, Y. T. Androgen deficiency and defective intracrine processing of dehydroepiandrosterone in salivary glands in Sjogren's syndrome. J Rheumatol. 2008;35(11):2229-2235. View abstract.
Rao, M. S., Subbarao, V., Yeldandi, A. V., and Reddy, J. K. Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Res. 5-15-1992;52(10):2977-2979. View abstract.
Rasmussen, K. R., Arrowood, M. J., and Healey, M. C. Effectiveness of dehydroepiandrosterone in reduction of cryptosporidial activity in immunosuppressed rats. Antimicrob.Agents Chemother 1992;36(1):220-222. View abstract.
Regelson, W. and Kalimi, M. Dehydroepiandrosterone (DHEA)--the multifunctional steroid. II. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action? Ann N.Y.Acad.Sci. 5-31-1994;719:564-575. View abstract.
Regelson, W., Loria, R., and Kalimi, M. Dehydroepiandrosterone (DHEA)--the "mother steroid". I. Immunologic action. Ann N.Y.Acad.Sci. 5-31-1994;719:553-563. View abstract.
Rice, S. P., Agarwal, N., Bolusani, H., Newcombe, R., Scanlon, M. F., Ludgate, M., and Rees, D. A. Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: a randomized crossover trial. J Clin Endocrinol.Metab 2009;94(6):1966-1972. View abstract.
Rice, S. P., Zhang, L., Grennan-Jones, F., Agarwal, N., Lewis, M. D., Rees, D. A., and Ludgate, M. Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue. Mol.Cell Endocrinol. 5-14-2010;320(1-2):51-57. View abstract.
Risdon, G., Kumar, V., and Bennett, M. Differential effects of dehydroepiandrosterone (DHEA) on murine lymphopoiesis and myelopoiesis. Exp.Hematol. 1991;19(2):128-131. View abstract.
Ritsner, M. S. and Strous, R. D. Neurocognitive deficits in schizophrenia are associated with alterations in blood levels of neurosteroids: a multiple regression analysis of findings from a double-blind, randomized, placebo-controlled, crossover trial with DHEA. J Psychiatr.Res 2010;44(2):75-80. View abstract.
Ritsner, M. S., Gibel, A., Ratner, Y., Tsinovoy, G., and Strous, R. D. Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial. J Clin Psychopharmacol. 2006;26(5):495-499. View abstract.
ROBERTS, K. D., VANDEWIELE, R. L., and Lieberman, S. The conversion in vivo of dehydroisoandrosterone sulfate to androsterone and etiocholanolone glucuronidates. J Biol.Chem 1961;236:2213-2215. View abstract.
Romanutti, C., Bruttomesso, A. C., Castilla, V., Bisceglia, J. A., Galagovsky, L. R., and Wachsman, M. B. In vitro antiviral activity of dehydroepiandrosterone and its synthetic derivatives against vesicular stomatitis virus. Vet.J 2009;182(2):327-335. View abstract.
Romanutti, C., Bruttomesso, A. C., Castilla, V., Galagovsky, L. R., and Wachsman, M. B. Anti-adenovirus activity of epiandrosterone and dehydroepiandrosterone derivatives. Chemotherapy 2010;56(2):158-165. View abstract.
Rommler, A. [Adrenopause and dehydroepiandrosterone: pharmacological therapy versus replacement therapy]. Gynakol.Geburtshilfliche Rundsch. 2003;43(2):79-90. View abstract.
Rosenfeld, R. S., Hellman, L., and Gallagher, T. F. Metabolism and interconversion of dehydroisoandrosterone and dehydroisoandrosterone sulfate. J Clin Endocrinol Metab 1972;35(2):187-193. View abstract.
Roth, M. Y., Page, S. T., Lin, K., Anawalt, B. D., Matsumoto, A. M., Marck, B., Bremner, W. J., and Amory, J. K. The effect of gonadotropin withdrawal and stimulation with human chorionic gonadotropin on intratesticular androstenedione and DHEA in normal men. J Clin Endocrinol.Metab 2011;96(4):1175-1181. View abstract.
Ruckert, C., Stuepp, Cdos S., Gottardi, B., Rosa, J., Cisilotto, J., Borges, F. P., Rosemberg, D. B., Bogo, M. R., Tasca, T., De Carli, G. A., and Bonan, C. D. Trichomonas vaginalis: dehydroepiandrosterone sulfate and 17beta-estradiol alter NTPDase activity and gene expression. Exp.Parasitol. 2010;125(3):187-195. View abstract.
Sahelian, R. and Borken, S. Dehydroepiandrosterone and cardiac arrhythmia. Ann Intern.Med 10-1-1998;129(7):588. View abstract.
Sanders, J. L., Boudreau, R. M., Cappola, A. R., Arnold, A. M., Robbins, J., Cushman, M., and Newman, A. B. Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study. J Am Geriatr.Soc 2010;58(3):421-426. View abstract.
Sanders, J. L., Cappola, A. R., Arnold, A. M., Boudreau, R. M., Chaves, P. H., Robbins, J., Cushman, M., and Newman, A. B. Concurrent change in dehydroepiandrosterone sulfate and functional performance in the oldest old: results from the Cardiovascular Health Study All Stars study. J Gerontol.A Biol.Sci Med Sci 2010;65(9):976-981. View abstract.
Sawalha, A. H. and Kovats, S. Dehydroepiandrosterone in systemic lupus erythematosus. Curr Rheumatol.Rep. 2008;10(4):286-291. View abstract.
Schriock, E. D., Buffington, C. K., Givens, J. R., and Buster, J. E. Enhanced post-receptor insulin effects in women following dehydroepiandrosterone infusion. J Soc Gynecol.Investig. 1994;1(1):74-78. View abstract.
Schurr, M. J., Fabian, T. C., Croce, M. A., Varnavas, L. E., and Proctor, K. G. Dehydroepiandrosterone, an endogenous immune modulator, after traumatic shock. Shock 1997;7(1):55-59. View abstract.
Selye, H., Tache, Y., and Szabo, S. Interruption of pregnancy by various steroids. Fertil.Steril. 1971;22(11):735-740. View abstract.
Shealy, C. N. A review of dehydroepiandrosterone (DHEA). Integr.Physiol Behav Sci 1995;30(4):308-313. View abstract.
Shufelt, C., Bretsky, P., Almeida, C. M., Johnson, B. D., Shaw, L. J., Azziz, R., Braunstein, G. D., Pepine, C. J., Bittner, V., Vido, D. A., Stanczyk, F. Z., and Bairey Merz, C. N. DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health--National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE). J Clin Endocrinol.Metab 2010;95(11):4985-4992. View abstract.
Shun YP, Shun LH, Feng YY, and et al. [The effect of DHEA on body fat distribution and serum lipids in elderly overweight males]. Practical Geriatrics 1999;13(1):31-33.
Slater CC, Zhang C, Guan C, and et al. Dihydrotestosterone (DHT) accumulation as a consequence of long-term DHEA supplementation in postmenopausal women [abstract]. Fertility and Sterility 2000;73(4):7S-8S.
Solano, M. E., Elia, E., Luchetti, C. G., Sander, V., Di, Girolamo G., Gonzalez, C., and Motta, A. B. Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice. Reprod.Fertil.Dev. 2006;18(5):533-544. View abstract.
Sonka J, Gregorova I, and Krizek V. Dehydroepiandrosterone in gout. Steroids 1964;4(6):843-847.
Sonmezer, M., Cil, A. P., and Oktay, K. Ongoing pregnancies from early retrieval of prematurely developing antral follicles after DHEA supplementation. Reprod.Biomed.Online. 2009;19(6):816-819. View abstract.
Spaan, M., Porola, P., Laine, M., Rozman, B., Azuma, M., and Konttinen, Y. T. Healthy human salivary glands contain a DHEA-sulphate processing intracrine machinery, which is deranged in primary Sjogren's syndrome. J Cell Mol.Med 2009;13(7):1261-1270. View abstract.
Stanczyk, F. Z., Slater, C. C., Ramos, D. E., Azen, C., Cherala, G., Hakala, C., Abraham, G., and Roy, S. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term oral dehydroepiandrosterone treatment in postmenopausal women. Menopause. 2009;16(2):272-278. View abstract.
Stewart, P. M. Aging and fountain-of-youth hormones. N Engl.J Med 10-19-2006;355(16):1724-1726. View abstract.
Straub, R. H., Konecna, L., Hrach, S., Rothe, G., Kreutz, M., Scholmerich, J., Falk, W., and Lang, B. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab 1998;83(6):2012-2017. View abstract.
Straub, R. H., Scholmerich, J., and Zietz, B. Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones. Z Rheumatol. 2000;59 Suppl 2:II/108-II/118. View abstract.
Straub, R. H., Weidler, C., Demmel, B., Herrmann, M., Kees, F., Schmidt, M., Scholmerich, J., and Schedel, J. Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum.Dis 2004;63(8):961-968. View abstract.
Strous, R. D., Maayan, R., Kaminsky, M., Blumensohn, R., Weizman, A., and Spivak, B. DHEA and DHEA-S levels in hospitalized adolescents with first-episode schizophrenia and conduct disorder: a comparison study. Eur Neuropsychopharmacol. 2009;19(7):499-503. View abstract.
Strous, R. D., Maayan, R., Lapidus, R., Stryjer, R., Lustig, M., Kotler, M., and Weizman, A. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry 2003;60(2):133-141.
Sulcova, J., Hill, M., Hampl, R., Masek, Z., Novacek, A., Ceska, R., and Starka, L. Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men. Physiol Res 2000;49(6):685-693. View abstract.
Sullivan, D. A., Belanger, A., Cermak, J. M., Berube, R., Papas, A. S., Sullivan, R. M., Yamagami, H., Dana, M. R., and Labrie, F. Are women with Sjogren's syndrome androgen-deficient? J Rheumatol. 2003;30(11):2413-2419. View abstract.
Sumida, Y., Yonei, Y., Kanemasa, K., Hara, T., Inada, Y., Sakai, K., Imai, S., Hibino, S., Yamaguchi, K., Mitsuyoshi, H., Yasui, K., Minami, M., Itoh, Y., Naito, Y., Yoshikawa, T., and Okanoue, T. Lower circulating levels of dehydroepiandrosterone, independent of insulin resistance, is an important determinant of severity of non-alcoholic steatohepatitis in Japanese patients. Hepatol.Res 2010;40(9):901-910. View abstract.
Sunkara, S. K., Pundir, J., and Khalaf, Y. Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis. Reprod.Biomed.Online. 2011;22(6):545-555. View abstract.
Suzuki, T., Suzuki, N., Engleman, E. G., Mizushima, Y., and Sakane, T. Low serum levels of dehydroepiandrosterone may cause deficient IL-2 production by lymphocytes in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1995;99(2):251-255. View abstract.
Tagliaferro, A. R., Roebuck, B. D., Ronan, A. M., and Meeker, L. D. Enhancement of pancreatic carcinogenesis by dehydroepiandrosterone. Adv.Exp.Med Biol. 1992;322:119-129. View abstract.
Tagliaferro, A. R., Ronan, A. M., Payne, J., Meeker, L. D., and Tse, S. Increased lipolysis to beta-adrenergic stimulation after dehydroepiandrosterone treatment in rats. Am J Physiol 1995;268(6 Pt 2):R1374-R1380. View abstract.
Takayanagi, R., Goto, K., Suzuki, S., Tanaka, S., Shimoda, S., and Nawata, H. Dehydroepiandrosterone (DHEA) as a possible source for estrogen formation in bone cells: correlation between bone mineral density and serum DHEA-sulfate concentration in postmenopausal women, and the presence of aromatase to be enhanced by 1,25-dihydroxyvitamin D3 in human osteoblasts. Mech.Ageing Dev. 4-30-2002;123(8):1107-1114. View abstract.
Taylor, M. K., Padilla, G. A., Stanfill, K. E., Markham, A. E., Khosravi, J. Y., Ward, M. D., and Koehler, M. M. Effects of dehydroepiandrosterone supplementation during stressful military training: a randomized, controlled, double-blind field study. Stress. 2012;15(1):85-96. View abstract.
Torricelli, M., Voltolini, C., Galleri, L., Biliotti, G., Giovannelli, A., De, Bonis M., De, Pascalis F., Centini, G., and Petraglia, F. Amniotic fluid urocortin, CRF, oestriol, dehydroepiandrosterone sulfate and cortisol concentrations at mid-trimester: putative relationship with preterm delivery. Eur J Obstet.Gynecol.Reprod.Biol. 2009;146(2):169-173. View abstract.
Traish, A. M., Kang, H. P., Saad, F., and Guay, A. T. Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology. J Sex Med 2011;8(11):2960-2982. View abstract.
Tsuji, K., Furutama, D., Tagami, M., and Ohsawa, N. Specific binding and effects of dehydroepiandrosterone sulfate (DHEA-S) on skeletal muscle cells: possible implication for DHEA-S replacement therapy in patients with myotonic dystrophy. Life Sci. 1999;65(1):17-26. View abstract.
Umezaki, H., Hess, D. L., Valenzuela, G. J., and Ducsay, C. A. Fetectomy alters maternal pituitary-adrenal function in pregnant rhesus macaques. Biol Reprod. 2001;65(5):1616-1621. View abstract.
Uozumi, K., Uematsu, T., Otsuka, M., Nakano, S., Takatsuka, Y., Iwahashi, M., Hanada, S., and Arima, T. Serum dehydroepiandrosterone and DHEA-sulfate in patients with adult T- cell leukemia and human T-lymphotropic virus type I carriers. Am J Hematol. 1996;53(3):165-168. View abstract.
Valenti, G., Ferrucci, L., Lauretani, F., Ceresini, G., Bandinelli, S., Luci, M., Ceda, G., Maggio, M., and Schwartz, R. S. Dehydroepiandrosterone sulfate and cognitive function in the elderly: The InCHIANTI Study. J Endocrinol.Invest 2009;32(9):766-772. View abstract.
Valtysdottir, S. T., Wide, L., and Hallgren, R. Mental wellbeing and quality of sexual life in women with primary Sjogren's syndrome are related to circulating dehydroepiandrosterone sulphate. Ann Rheum.Dis 2003;62(9):875-879. View abstract.
Van Niekerk, J. K., Huppert, F. A., and Herbert, J. Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation. Psychoneuroendocrinology 2001;26(6):591-612. View abstract.
Van Vollenhoven RF and McDevitt H. Studies of the treatment of nephritis in NZB/NZW mice with dehydroepiandrosterone [abstract]. Arthritis Rheum 1992;35 (suppl):S207.
Van Vollenhoven RF, Morabito LM, Engleman EG, and et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone. Two-year follow-up from an open-label clinical trial [abstract]. Arthritis Rheum 1994;37:S407.
Van Vollenhoven RF, Morales A, Yen S, and et al. In patients with systemic lupus erythematosus, treatment with oral dehydroepiandrosterones restores abnormally low in vitro production of IL-2, IL-6 and TNF-alpha [abstract]. Arthritis Rheum 1994;37:S407.
van Weering, H. G., Gutknecht, D. R., and Schats, R. Augmentation of ovarian response by dehydroepiandrosterone. Hum Reprod. 2001;16(7):1537-1539. View abstract.
Villareal, D. T. and Holloszy, J. O. DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol.Metab 2006;291(5):E1003-E1008. View abstract.
Wang, F., Koskela, A., Hamalainen, E., Turpeinen, U., Savolainen-Peltonen, H., Mikkola, T. S., Vihma, V., Adlercreutz, H., and Tikkanen, M. J. Quantitative determination of dehydroepiandrosterone fatty acyl esters in human female adipose tissue and serum using mass spectrometric methods. J Steroid Biochem Mol.Biol. 2011;124(3-5):93-98. View abstract.
Wang, L. J., Huang, Y. S., Hsiao, C. C., Chiang, Y. L., Wu, C. C., Shang, Z. Y., and Chen, C. K. Salivary dehydroepiandrosterone, but not cortisol, is associated with attention deficit hyperactivity disorder. World J Biol.Psychiatry 2011;12(2):99-109. View abstract.
Wang, M. J., Huang, H. M., Chen, H. L., Kuo, J. S., and Jeng, K. C. Dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in BV-2 microglia. J Neurochem. 2001;77(3):830-838. View abstract.
Wellman, M., Shane-McWhorter, L., Orlando, and Jennings, J. P. The role of dehydroepiandrosterone in diabetes mellitus. Pharmacotherapy 1999;19(5):582-591. View abstract.
Williams, M. R., Dawood, T., Ling, S., Dai, A., Lew, R., Myles, K., Funder, J. W., Sudhir, K., and Komesaroff, P. A. Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J.Clin.Endocrinol.Metab 2004;89(9):4708-4715. View abstract.
Wisniewski, T. L., Hilton, C. W., Morse, E. V., and Svec, F. The relationship of serum DHEA-S and cortisol levels to measures of immune function in human immunodeficiency virus-related illness. Am J Med Sci 1993;305(2):79-83. View abstract.
Wolf, O. T., Kudielka, B. M., Hellhammer, D. H., Hellhammer, J., and Kirschbaum, C. Opposing effects of DHEA replacement in elderly subjects on declarative memory and attention after exposure to a laboratory stressor. Psychoneuroendocrinology 1998;23(6):617-629. View abstract.
Wolf, O. T., Naumann, E., Hellhammer, D. H., and Kirschbaum, C. Effects of dehydroepiandrosterone replacement in elderly men on event- related potentials, memory, and well-being. J Gerontol.A Biol.Sci.Med.Sci. 1998;53(5):M385-M390. View abstract.
Xu, B., Yang, R., Chang, F., Chen, L., Xie, G., Sokabe, M., and Chen, L. Neurosteroid PREGS protects neurite growth and survival of newborn neurons in the hippocampal dentate gyrus of APPswe/PS1dE9 mice. Curr Alzheimer Res 2012;9(3):361-372. View abstract.
Yamaguchi, Y., Tanaka, S., Yamakawa, T., Kimura, M., Ukawa, K., Yamada, Y., Ishihara, M., and Sekihara, H. Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia. Clin Endocrinol.(Oxf) 1998;49(3):377-383. View abstract.
Yanase, T., Fukahori, M., Taniguchi, S., Nishi, Y., Sakai, Y., Takayanagi, R., Haji, M., and Nawata, H. Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in Alzheimer's disease and in cerebrovascular dementia. Endocr.J 1996;43(1):119-123. View abstract.
Yanase, T., Suzuki, S., Goto, K., Nawata, H., and Takayanagi, R. [DHEA and bone metabolism]. Clin Calcium 2003;13(11):1419-1424. View abstract.
Yang, J. Y., Schwartz, A., and Henderson, E. E. Inhibition of HIV-1 latency reactivation by dehydroepiandrosterone (DHEA) and an analog of DHEA. AIDS Res Hum Retroviruses 1993;9(8):747-754. View abstract.
Yehuda, R., Brand, S. R., Golier, J. A., and Yang, R. K. Clinical correlates of DHEA associated with post-traumatic stress disorder. Acta Psychiatr.Scand. 2006;114(3):187-193. View abstract.
Young, J., Couzinet, B., Nahoul, K., Brailly, S., Chanson, P., Baulieu, E. E., and Schaison, G. Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans. J Clin Endocrinol.Metab 1997;82(8):2578-2585. View abstract.
Zenk, J. L., Frestedt, J. L., and Kuskowski, M. A. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18(9):629-634. View abstract.
Abrams, D. I., Shade, S. B., Couey, P., McCune, J. M., Lo, J., Bacchetti, P., Chang, B., Epling, L., Liegler, T., Grant, R. M. Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study. AIDS Res Hum Retroviruses 2007;23(1):77-85. View abstract.
Acacio BD, Stanczyk FZ, Mullin P, et al. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men. Fertil Steril 2004;81:595-604. View abstract.
Aisaka, K., Mori, H., Ogawa, T., Kigawa, T. Effects of dehydroepiandrosterone-sulphate (DHEA-S) administration on puerperal lactation and maternal prolactin and estradiol levels. Nippon Sanka Fujinka Gakkai Zasshi 1984;36(10):1935-42. View abstract.
Al-Dujaili, E. A., Kenyon, C. J., Nicol, M. R., Mason, J. I. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity. Mol Cell Endocrinol 2011;336(1-2):102-9. View abstract.
Alfano AP, Taylor AG, Foresman PA, et al. Static magnetic fields for treatment of fibromyalgia: a randomized controlled trial. J Altern Complement Med 2001;7(1):53-64. View abstract.
Alkatib AA, Cosma M, Elamin MB, et al. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency. J Clin Endocrinol Metab 2009;94:3676-81. View abstract.
Andus, T., Klebl, F., Rogler, G., Bregenzer, N., Scholmerich, J., Straub, R. H. Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study. Aliment Pharmacol Ther 2003;17(3):409-14. View abstract.
Araghiniknam M, Chung S, Nelson-White T, et al. Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci 1996;59:PL147-57.. View abstract.
Araneo, B. Daynes, R. Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury. Endocrinology 1995;136(2):393-401. View abstract.
Arlt W, Callies F, Koehler I, et al. Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion. J Clin Endocrinol Metab 2001;86:4686-92.. View abstract.
Arlt W, Callies F, van Vlijmen JC, et al. Dehydroepiandosterone replacement in women with adrenal insufficiency. N Engl J Med 1999;341:1013-20. View abstract.
Arlt W, Haas J, Callies F, et al. Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. J Clin Endocrinol Metab 1999;84:2170-6. View abstract.
Arlt W, Justl H, Callies F, et al. Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression. [Abstract] J Clin Endocrinol Metab 1998;83:1928-34. View abstract.
Arlt W. Quality of life in Addison's disease-the case for DHEA replacement. Clin Endocrinol (Oxf) 2002;56(5):573-4. View abstract.
Arlt, W., Callies, F., Allolio, B. DHEA replacement in women with adrenal insufficiency--pharmacokinetics, bioconversion and clinical effects on well-being, sexuality and cognition. Endocr Res 2000;26(4):505-11. View abstract.
Artini, P. G., Simi, G., Ruggiero, M., Pinelli, S., Di Berardino, O. M., Papini, F., Papini, S., Monteleone, P., Cela, V. DHEA supplementation improves follicular microenviroment in poor responder patients. Gynecol Endocrinol 2012;28(9):669-73. View abstract.
Baker WL, Karan S, Kenny AM. Effect of dehydroepiandrosterone on muscle strength and physical function in older adults: a systematic review. J Am Geriatr Soc 2011;59:997-1002. View abstract.
Barnhart KT, Freeman E, Grisso JA, et al. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab 1999;84:3896-902. View abstract.
Barrett-Connor E, von Muhlen D, Laughlin GA, Kripke A. Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo Study. J Am Geriatr Soc 1999;47:685-91.. View abstract.
Barry NN, McGuire JL, van Vollenhoven RF. Dehydroepiandrosterone in systemic lupus erythematosus: relationship between dosage, serum levels, and clinical response. J Rheumatol 1998;25:2352-6. View abstract.
Basu R., Dalla Man C., Campioni M., Basu A., Nair K. S., Jensen M. D., Khosla S., Klee G., Toffolo G., Cobelli C., Rizza R. A. Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. Diabetes 2007;56(3):753-66. View abstract.
Bates GW Jr, Egerman RS, Umstot ES, et al. Dehydroepiandrosterone attenuates study-induced declines in insulin sensitivity in postmenopausal women. Ann N Y Acad Sci 1995;774:291-3. View abstract.
Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging. Contribution of the DHEAge study to a sociobiomedical issue. Proc Natl Acad Sci U S A 2000;97:4279-84. View abstract.
Beer NA, Jakubowicz DJ, Matt DW, et al. Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men. Am J Med Sci 1996;311:205-10.. View abstract.
Bernardi, F., Pieri, M., Stomati, M., Luisi, S., Palumbo, M., Pluchino, N., Ceccarelli, C., Genazzani, A. R. Effect of different hormonal replacement therapies on circulating allopregnanolone and dehydroepiandrosterone levels in postmenopausal women. Gynecol Endocrinol 2003;17(1):65-77. View abstract.
Bertoni, A., Rastoldo, A., Sarasso, C., Di Vito C., Sampietro, S., Nalin, M., Bagarotti, A., Sinigaglia, F. Dehydroepiandrosterone-sulfate inhibits thrombin-induced platelet aggregation. Steroids 2012;77(3):260-8. View abstract.
Bilger, M., Speraw, S., LaFranchi, S. H., Hanna, C. E. Androgen replacement in adolescents and young women with hypopituitarism. J Pediatr Endocrinol Metab 2005;18(4):355-362. View abstract.
Binder, G., Weber, S., Ehrismann, M., Zaiser, N., Meisner, C., Ranke, M. B., Maier, L., Wudy, S. A., Hartmann, M. F., Heinrich, U., Bettendorf, M., Doerr, H. G., Pfaeffle, R. W., Keller, E. Effects of dehydroepiandrosterone therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency: a double-blind, randomized, placebo-controlled phase III trial. J Clin Endocrinol Metab 2009;94(4):1182-90. View abstract.
Bloch M, Meiboom H, Zaig I, et al. The use of dehydroepiandrosterone in the treatment of hypoactive sexual desire disorder: a report of gender differences. Eur Neuropsychopharmacol 2013;23(8):910-8. View abstract.
Bloch M, Schmidt PJ, Danaceau MA, et al. Dehydroepiandrosterone treatment of midlife dysthymia. Biol Psychiatry 1999;45:1533-41. View abstract.
Bloch, M., Ish-Shalom, S., Greenman, Y., Klein, E., Latzer, Y. Dehydroepiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa-a pilot study. Psychiatry Res 2012;200(2-3):544-9. View abstract.
Bonorden, M. J., Greany, K. A., Wangen, K. E., Phipps, W. R., Feirtag, J., Adlercreutz, H., Kurzer, M. S. Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women. Eur J Clin Nutr 2004;58(12):1635-42. View abstract.
Boxer, R. S., Kleppinger, A., Brindisi, J., Feinn, R., Burleson, J. A., Kenny, A. M. Effects of dehydroepiandrosterone (DHEA) on cardiovascular risk factors in older women with frailty characteristics. Age Ageing 2010;39(4):451-8. View abstract.
Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000;10:340-59. View abstract.
Buisson C, Frelat C, Privat K, Martinat N, Audran M, Collomp K. Metabolic and isotopic signature of short-term DHEA administration in women: Comparison with findings in men. Drug Test Anal. 2018;10(11-12):1744-1754. View abstract.
Buvat J. Androgen therapy with dehydroepiandrosterone. World J Urol. 2003;21:346-55. View abstract.
Calhoun K, Pommier R, Cheek J, et al. The effect of high dehydroepiandrosterone sulfate levels on tamoxifen blockade and breast cancer progression. Am J Surg 2003;185:411-5.. View abstract.
Calhoun KE, Pommier RF, Muller P, et al. Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant. Arch Surg 2003;138:879-83.. View abstract.
Callies F, Arlt W, Siekmann L, et al. Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females. Steroids 2000;65:98-102. View abstract.
Callies F, Fassnacht M, van Vlijmen JC, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency: effects on body composition, serum leptin, bone turnover, and exercise capacity. J Clin Endocrinol Metab 2001;86:1968-72.. View abstract.
Casson PR, Andersen RN, Herrod HG, et al. Oral dehyroepiandosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol 1995;1536-9. View abstract.
Casson PR, Faquin LC, Stentz FB. Replacement of dehydroepiandrosterone enhances T-lymphocyte insulin binding in postmenopausal women. (abstract) Fertil Steril 1995;63:1027-31. View abstract.
Casson, P. R., Santoro, N., Elkind-Hirsch, K., Carson, S. A., Hornsby, P. J., Abraham, G., Buster, J. E. Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial. Fertil Steril 1998;70(1):107-110. View abstract.
Caufriez A, Leproult R, L'Hermite-Baleriaux M, et al. Effects of a 3-week dehydroepiandrosterone administration on sleep, sex steroids and multiple 24-h hormonal profiles in postmenopausal women: a pilot study. Clin Endocrinol (Oxf) 2013;79(5):716-24. View abstract.
Chen H, Jin Z, Sun C, Santos HO, Kord Varkaneh H. Effects of dehydroepiandrosterone (DHEA) supplementation on cortisol, leptin, adiponectin, and liver enzyme levels: A systematic review and meta-analysis of randomised clinical trials. Int J Clin Pract 2021;75(11):e14698. View abstract.
Chen SN, Tsui KH, Wang PH, Chern CU, Wen ZH, Lin LT. Dehydroepiandrosterone supplementation improves the outcomes of in vitro fertilization cycles in older patients with diminished ovarian reserve. Front Endocrinol (Lausanne). 2019;10:800. View abstract.
Chern CU, Tsui KH, Vitale SG, et al. Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study. Reprod Biol Endocrinol. 2018;16(1):90. View abstract.
Christeff N, Gherbi N, Mammes O, et al. Serum cortisol and DHEA concentrations during HIV infection. Psychoneuroendocrinology 1997;22:S11-8. View abstract.
Christiansen, J. J., Andersen, N. H., Sorensen, K. E., Pedersen, E. M., Bennett, P., Andersen, M., Christiansen, J. S., Jorgensen, J. O., Gravholt, C. H. Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and cardiovascular parameters despite normalization of androgen status. Clin Endocrinol (Oxf) 2007;66(3):426-33. View abstract.
Christiansen, J. J., Bruun, J. M., Christiansen, J. S., Jorgensen, J. O., Gravholt, C. H. Long-term DHEA substitution in female adrenocortical failure, body composition, muscle function, and bone metabolism: a randomized trial. Eur J Endocrinol 2011;165(2):293-300. View abstract.
Cibula, D., Fanta, M., Vrbikova, J., Stanicka, S., Dvorakova, K., Hill, M., Skrha, J., Zivny, J., Skrenkova, J. The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients. Hum Reprod 2005;20(1):180-4. View abstract.
Ciolino H, MacDonald C, Memon O, et al. Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo. Int J Cancer 2003;105:321-5 . View abstract.
Crosbie, D., Black, C., McIntyre, L., Royle, P. L., Thomas, S. Dehydroepiandrosterone for systemic lupus erythematosus. Cochrane Database Syst Rev 2007;(4):CD005114. View abstract.
Cui, Y., Choi, I. S., Koh, Y. A., Lin, X. H., Cho, Y. B., Won, Y. H. Effects of combined BCG and DHEA treatment in preventing the development of asthma. Immunol Invest 2008;37(3):191-202. View abstract.
Dayal, M., Sammel, M. D., Zhao, J., Hummel, A. C., Vandenbourne, K., Barnhart, K. T. Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids. J Womens Health (Larchmt) 2005;14(5):391-400. View abstract.
Dean CE. Prasterone (DHEA) and mania. Ann Pharmacother 2000;34:1419-22. View abstract.
Dhatariya, K. K., Greenlund, L. J., Bigelow, M. L., Thapa, P., Oberg, A. L., Ford, G. C., Schimke, J. M., Nair, K. S. Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. Mayo Clin Proc 2008;83(11):1218-25. View abstract.
Nestler, J. E. and Kahwash, Z. Sex-specific action of insulin to acutely increase the metabolic clearance rate of dehydroepiandrosterone in humans. J Clin.Invest 1994;94(4):1484-1489. View abstract.
Nestler, J. E., Barlascini, C. O., Clore, J. N., and Blackard, W. G. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin.Endocrinol.Metab 1988;66(1):57-61. View abstract.
Nestler, J. E., Beer, N. A., Jakubowicz, D. J., and Beer, R. M. Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men. J Clin Endocrinol Metab 1994;78(3):549-554. View abstract.
Nestler, J. E., Beer, N. A., Jakubowicz, D. J., Colombo, C., and Beer, R. M. Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. J Clin.Endocrinol.Metab 1995;80(2):700-706. View abstract.
Nestler, J. E., Clore, J. N., Strauss, J. F., III, and Blackard, W. G. The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. J Clin Endocrinol Metab 1987;64(1):180-184. View abstract.
Nestler, J. E., Usiskin, K. S., Barlascini, C. O., Welty, D. F., Clore, J. N., and Blackard, W. G. Suppression of serum dehydroepiandrosterone sulfate levels by insulin: an evaluation of possible mechanisms. J Clin Endocrinol Metab 1989;69(5):1040-1046. View abstract.
Nogueira, J. M., Pinto, P. L., Loureiro, V., Prates, S., Gaspar, A., Almeida, M. M., and Pinto, J. E. Soluble CD30, dehydroepiandrosterone sulfate and dehydroepiandrosterone in atopic and non atopic children. Allerg.Immunol (Paris) 1998;30(1):3-8. View abstract.
Nordin, B. E., Robertson, A., Seamark, R. F., Bridges, A., Philcox, J. C., Need, A. G., Horowitz, M., Morris, H. A., and Deam, S. The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women. J Clin Endocrinol Metab 1985;60(4):651-657. View abstract.
Oberbeck, R., Dahlweid, M., Koch, R., van Griensven, M., Emmendorfer, A., Tscherne, H., and Pape, H. C. Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. Crit Care Med 2001;29(2):380-384. View abstract.
Olff, M., de Vries, G. J., Guzelcan, Y., Assies, J., and Gersons, B. P. Changes in cortisol and DHEA plasma levels after psychotherapy for PTSD. Psychoneuroendocrinology 2007;32(6):619-626. View abstract.
Liu, X., Arnold, J. T., and Blackman, M. R. Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells. Endocrinology 2010;151(4):1428-1440. View abstract.
Longcope, C. Dehydroepiandrosterone metabolism. J Endocrinol 1996;150 Suppl:S125-S127. View abstract.
Loria, R. M., Inge, T. H., Cook, S. S., Szakal, A. K., and Regelson, W. Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA). J Med Virol. 1988;26(3):301-314. View abstract.
Luboshitzky, R., Qupti, G., Ishay, A., Shen-Orr, Z., and Herer, P. Increased urinary 6-sulfatoxymelatonin excretion in women with non- classical steroid 21-hydroxylase deficiency. Neuroendocrinol.Lett 2001;22(5):332-336. View abstract.
Maayan, R., Yoran-Hegesh, R., Strous, R., Nechmad, A., Averbuch, E., Weizman, A., and Spivak, B. Three-month treatment course of methylphenidate increases plasma levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) in attention deficit hyperactivity disorder. Neuropsychobiology 2003;48(3):111-115. View abstract.
Maggio, M., Lauretani, F., Ceda, G. P., Bandinelli, S., Ling, S. M., Metter, E. J., Artoni, A., Carassale, L., Cazzato, A., Ceresini, G., Guralnik, J. M., Basaria, S., Valenti, G., and Ferrucci, L. Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. Arch.Intern.Med 11-12-2007;167(20):2249-2254. View abstract.
Marchandise, B. and Lederer, J. [Gynecomastia produced by dehydroepiandrosterone excess]. Rev Fr.Endocrinol Clin 1966;7(5):383-387. View abstract.
Mattson, L. A., Cullberg, G., Tangkeo, P., Zador, G., and Samsioe, G. Administration of dehydroepiandrosterone enanthate to oophorectomized women--effects on sex hormones and lipid metabolism. Maturitas 1980;2(4):301-309. View abstract.
May, M., Holmes, E., Rogers, W., and Poth, M. Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone. Life Sci 1990;46(22):1627-1631. View abstract.
Mayer, D., Forstner, K., and Kopplow, K. Induction and modulation of hepatic preneoplasia and neoplasia in the rat by dehydroepiandrosterone. Toxicol.Pathol. 2003;31(1):103-112. View abstract.
McIntosh MK and Berdanier CD. Influence of dehydroepiandrosterone (DHEA) on the thyroid hormone status of BHE/cdb rats. J Nutr Biochem 1992;3:194-199.
Mease PJ, Merrill JT, Lahita RG, and et al. GL701 (Prasterone, DHEA) improves systemic lupus erythematosus. Arthritis Rheum 2000;43(suppl):S271.
Mease PL, Ginzler EM, Gluck OS, and et al. Improvement in bone mineral density in steroid-treated patients during treatment with GL701 (Prasterone, DHEA). Arthritis Rheum 2000;43(suppl):S230.
Menzel, P. and Oertel, G. W. [Steroids in plasma and urine after i.m. injection of dehydroepiandrosterone-enanthate]. Arzneimittelforschung. 1971;21(7):1034-1037. View abstract.
Miklos, S. Dehydroepiandrosterone sulphate in the diagnosis of osteoporosis. Acta Biomed.Ateneo.Parmense. 1995;66(3-4):139-146. View abstract.
Miller, K. K., Cai, J., Ripp, S. L., Pierce, W. M., Jr., Rushmore, T. H., and Prough, R. A. Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450. Drug Metab Dispos. 2004;32(3):305-313. View abstract.
Mizokami, A., Koh, E., Izumi, K., Narimoto, K., Takeda, M., Honma, S., Dai, J., Keller, E. T., and Namiki, M. Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone. Endocr.Relat Cancer 2009;16(4):1139-1155. View abstract.
Mochizuki, M. and Maruo, T. Effect of dehydroepiandrosterone sulfate on uterine cervical ripening in late pregnancy. Acta Physiol Hung. 1985;65(3):267-274. View abstract.
Morgan, C. A., III, Southwick, S., Hazlett, G., Rasmusson, A., Hoyt, G., Zimolo, Z., and Charney, D. Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation, and objective performance in humans exposed to acute stress. Arch.Gen.Psychiatry 2004;61(8):819-825. View abstract.
Morrison, M. F., Ten Have, T., Freeman, E. W., Sammel, M. D., and Grisso, J. A. DHEA-S levels and depressive symptoms in a cohort of African American and Caucasian women in the late reproductive years. Biol Psychiatry 11-1-2001;50(9):705-711. View abstract.
Munarriz RM, Talakoub L, Flaherty E, and et al. Hormone, sexual function and personal sexual distress outcomes following dehydroepiandosterone (DHEA) treatment for multi-dimensional female sexual dysfunction and androgen deficiency syndrome [abstract]. American Urological Association Annual Meeting, June 2-7 2001.
Munarriz, R., Talakoub, L., Flaherty, E., Gioia, M., Hoag, L., Kim, N. N., Traish, A., Goldstein, I., Guay, A., and Spark, R. Androgen replacement therapy with dehydroepiandrosterone for androgen insufficiency and female sexual dysfunction: androgen and questionnaire results. J Sex Marital Ther 2002;28 Suppl 1:165-173. View abstract.
Murialdo, G., Barreca, A., Nobili, F., Rollero, A., Timossi, G., Gianelli, M. V., Copello, F., Rodriguez, G., and Polleri, A. Relationships between cortisol, dehydroepiandrosterone sulphate and insulin-like growth factor-I system in dementia. J Endocrinol Invest 2001;24(3):139-146. View abstract.
Goyal, R. O., Sagar, R., Ammini, A. C., Khurana, M. L., and Alias, A. G. Negative correlation between negative symptoms of schizophrenia and testosterone levels. Ann.N Y.Acad.Sci 2004;1032:291-294. View abstract.
Grasfeder, L. L., Gaillard, S., Hammes, S. R., Ilkayeva, O., Newgard, C. B., Hochberg, R. B., Dwyer, M. A., Chang, C. Y., and McDonnell, D. P. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Mol.Endocrinol. 2009;23(8):1171-1182. View abstract.
Gray, A., Feldman, H. A., McKinlay, J. B., and Longcope, C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin.Endocrinol.Metab 1991;73(5):1016-1025. View abstract.
Haffner, S. M., Valdez, R. A., Mykkanen, L., Stern, M. P., and Katz, M. S. Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism 1994;43(5):599-603. View abstract.
Hall, G. M., Perry, L. A., and Spector, T. D. Depressed levels of dehydroepiandrosterone sulphate in postmenopausal women with rheumatoid arthritis but no relation with axial bone density. Ann Rheum Dis. 1993;52(3):211-214. View abstract.
Hammer, F., Subtil, S., Lux, P., Maser-Gluth, C., Stewart, P. M., Allolio, B., and Arlt, W. No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies. J Clin Endocrinol.Metab 2005;90(6):3600-3605. View abstract.
Hampl, R., Sulcova, J., Bilek, R., and Hill, M. How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influence thyroid function. Physiol Res 2006;55(1):49-54. View abstract.
Haning, R. V., Jr., Austin, C. W., Carlson, I. H., Kuzma, D. L., and Zweibel, W. J. Role of dehydroepiandrosterone sulfate as a prehormone for ovarian steroidogenesis. Obstet.Gynecol. 1985;65(2):199-205. View abstract.
Haning, R. V., Jr., Carlson, I. H., Flood, C. A., Hackett, R. J., and Longcope, C. Metabolism of dehydroepiandrosterone sulfate (DS) in normal women and women with high DS concentrations. J Clin Endocrinol.Metab 1991;73(6):1210-1215. View abstract.
Hartkamp, A., Geenen, R., Kruize, A. A., Bossema, E. R., Godaert, G. L., Bootsma, H., Bijlsma, J. W., and Derksen, R. H. Serum dehydroepiandrosterone sulphate levels and laboratory and clinical parameters indicating expression of disease are not associated with fatigue, well-being and functioning in patients with primary Sjogren's syndrome. Clin Exp.Rheumatol. 2011;29(2):318-321. View abstract.
Hata, T., Hashimoto, M., Senoh, D., Hata, K., Kitao, M., and Masumura, S. Effect of dehydroepiandrosterone sulfate on ophthalmic artery flow velocity waveforms in full-term pregnant women. Am J Perinatol. 1995;12(2):135-137. View abstract.
Hautanen, A., Manttari, M., Manninen, V., Tenkanen, L., Huttunen, J. K., Frick, M. H., and Adlercreutz, H. Adrenal androgens and testosterone as coronary risk factors in the Helsinki Heart Study. Atherosclerosis 1994;105(2):191-200. View abstract.
Hillen, T., Lun, A., Reischies, F. M., Borchelt, M., Steinhagen-Thiessen, E., and Schaub, R. T. DHEA-S plasma levels and incidence of Alzheimer's disease. Biol Psychiatry 1-15-2000;47(2):161-163. View abstract.
Hirao, T., Urata, Y., Kageyama, K., Ikezaki, M., Kawakatsu, M., Matsuse, M., Matsuo, T., Akishita, M., Nagata, I., and Kondo, T. Dehydroepiandrosterone augments sensitivity to gamma-ray irradiation in human H4 neuroglioma cells through down-regulation of Akt signaling. Free Radic.Res 2008;42(11-12):957-965. View abstract.
Hoffman, D. I., Klove, K., and Lobo, R. A. The prevalence and significance of elevated dehydroepiandrosterone sulfate levels in anovulatory women. Fertil.Steril. 1984;42(1):76-81. View abstract.
Howard, J. S., III. Severe psychosis and the adrenal androgens. Integr Physiol Behav.Sci 1992;27(3):209-215. View abstract.
Hsiao, C. C. Difference in pre- and post-treatment plasma DHEA levels were significantly and positively correlated with difference in pre- and post-treatment Hamilton depression scores following successful therapy for major depression. Psychoneuroendocrinology 2006;31(7):839-846. View abstract.
Huppert, F. A. and Van Niekerk, J. K. WITHDRAWN: Dehydroepiandrosterone (DHEA) supplementation for cognitive function. Cochrane Database.Syst.Rev. 2006;(2):CD000304. View abstract.
Izawa, S., Sugaya, N., Shirotsuki, K., Yamada, K. C., Ogawa, N., Ouchi, Y., Nagano, Y., Suzuki, K., and Nomura, S. Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes. Biol.Psychol. 2008;79(3):294-298. View abstract.
Jian, Z. W., Wu, S. Z., and Ruan, Y. J. [Relationship between dehydroepiandrosterone and arteriosclerosis in premenopausal and postmenopausal women]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2008;28(6):942-943. View abstract.
Johnson, R. Abnormal Testosterone:Epitestosterone ratios after dehydroepiandrosterone supplementation. Clin Chem 1999;45(2):163-164. View abstract.
Josipovic, B. and Josipovic, A. Basal levels of DHEAS as a marker for disease activity in premenopausal women with recent onset rheumatoid arthritis. J Rheumatol. 2002;29(8):1803-1805. View abstract.
Kaiman DS, Colker CM, Swain MA, Torina GC, and Shi Q. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research 2000;61(7):435-442.
Karp, G., Bentov, Y., Masalha, R., and Ifergane, G. Onset of late posttraumatic seizure after dehydroepiandrosterone treatment. Fertil.Steril. 2009;91(3):931-932. View abstract.
Kasperska-Zajac, A. E., Brzoza, Z. K., Koczy-Baron, E., and Jagodzinska, J. Dehydroepiandrosterone in therapy of allergic diseases. Recent Pat Inflamm.Allergy Drug Discov. 2009;3(3):211-213. View abstract.
Kasperska-Zajac, A., Brzoza, Z., and Rogala, B. Lower serum dehydroepiandrosterone sulphate concentration in chronic idiopathic urticaria: a secondary transient phenomenon? Br.J Dermatol. 2008;159(3):743-744. View abstract.
Kawano, H., Nagayoshi, Y., Soejima, H., Tanaka, Y., Yamabe, H., Kinoshita, Y., and Ogawa, H. Dehydroepiandrosterone levels vary according as heart failure condition in patients with idiopathic dilated cardiomyopathy. Int.J Cardiol. 4-10-2008;125(2):277-279. View abstract.
Kellner, M., Muhtz, C., Peter, F., Dunker, S., Wiedemann, K., and Yassouridis, A. Increased DHEA and DHEA-S plasma levels in patients with post-traumatic stress disorder and a history of childhood abuse. J Psychiatr.Res 2010;44(4):215-219. View abstract.
Khalkhali-Ellis, Z., Moore, T. L., and Hendrix, M. J. Reduced levels of testosterone and dehydroepiandrosterone sulphate in the serum and synovial fluid of juvenile rheumatoid arthritis patients correlates with disease severity. Clin Exp Rheumatol. 1998;16(6):753-756. View abstract.
Khorram, O., Vu, L., and Yen, S. S. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men. J Gerontol.A Biol Sci Med Sci 1997;52(1):M1-M7. View abstract.
Kocis, P. Prasterone. Am J Health Syst.Pharm. 11-15-2006;63(22):2201-2210. View abstract.
Kodama, M., Oyama, A., and Takagi, H. Control of interstitial pneumonia by drip infusion of megadose vitamin C, dehydroepiandrosterone and cortisol. A short review of our experience. In Vivo 2008;22(2):263-267. View abstract.
Koetz, K. R., Ventz, M., Diederich, S., and Quinkler, M. Bone mineral density is not significantly reduced in adult patients on low-dose glucocorticoid replacement therapy. J Clin Endocrinol.Metab 2012;97(1):85-92. View abstract.
Kumpfel, T., Then, Bergh F., Friess, E., Uhr, M., Yassouridis, A., Trenkwalder, C., and Holsboer, F. Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis. Neuroendocrinology 1999;70(6):431-438. View abstract.
Labrie, C., Flamand, M., Belanger, A., and Labrie, F. High bioavailability of dehydroepiandrosterone administered percutaneously in the rat. J Endocrinol 1996;150 Suppl:S107-S118. View abstract.
Labrie, F., Archer, D., Bouchard, C., Fortier, M., Cusan, L., Gomez, J. L., Girard, G., Baron, M., Ayotte, N., Moreau, M., Dube, R., Cote, I., Labrie, C., Lavoie, L., Berger, L., Gilbert, L., Martel, C., and Balser, J. Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women. Menopause. 2009;16(5):923-931. View abstract.
Labrie, F., Belanger, A., Cusan, L., and Candas, B. Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology. J Clin Endocrinol Metab 1997;82(8):2403-2409. View abstract.
Lahita, R. G. Dehydroepiandrosterone (DHEA) for serious disease, a possibility? Lupus 1999;8(3):169-170. View abstract.
Leal, A. M., Magalhaes, P. K., Souza, C. S., and Foss, N. T. Adrenocortical hormones and interleukin patterns in leprosy. Parasite Immunol. 2003;25(8-9):457-461. View abstract.
Leblhuber, F., Peichl, M., Neubauer, C., Reisecker, F., Steinparz, F. X., Windhager, E., and Maschek, W. Serum dehydroepiandrosterone and cortisol measurements in Huntington's chorea. J Neurol Sci 1995;132(1):76-79. View abstract.
Lee, K. S., Oh, K. Y., and Kim, B. C. Effects of dehydroepiandrosterone on collagen and collagenase gene expression by skin fibroblasts in culture. J Dermatol.Sci 2000;23(2):103-110. View abstract.
Lee, M. S., Yang, J. W., Ko, Y. H., Han, C., Kim, S. H., Lee, M. S., Joe, S. H., and Jung, I. K. Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder. Child Psychiatry Hum.Dev. 2008;39(2):201-209. View abstract.
Li, Y., Xia, Z., and Wang, M. Dehydroepiandrosterone inhibits CD40/CD40L expression on human umbilical vein endothelial cells induced by interferon gamma. Int.Immunopharmacol. 2009;9(2):168-172. View abstract.
Liu, D. and Dillon, J. S. Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2,3). J Biol.Chem 6-14-2002;277(24):21379-21388. View abstract.
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., and McKinlay, J. B. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol.Metab 2002;87(2):589-598. View abstract.
Fitzpatrick, J. L., Ripp, S. L., Smith, N. B., Pierce, W. M., Jr., and Prough, R. A. Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions. Arch.Biochem Biophys. 5-15-2001;389(2):278-287. View abstract.
Foldes, J., Feher, T., Feher, K. G., Kollin, E., and Bodrogi, L. Dehydroepiandrosterone sulphate (DS), dehydroepiandrosterone (D) and "free" dehydroepiandrosterone (FD) in the plasma of patients with thyroid diseases. Horm Metab Res 1983;15(12):623-624. View abstract.
Foldes, J., Lakatos, P., Zsadanyi, J., and Horvath, C. Decreased serum IGF-I and dehydroepiandrosterone sulphate may be risk factors for the development of reduced bone mass in postmenopausal women with endogenous subclinical hyperthyroidism. Eur J Endocrinol. 1997;136(3):277-281. View abstract.
Fukui, M., Kitagawa, Y., Nakamura, N., Kadono, M., Yoshida, M., Hirata, C., Wada, K., Hasegawa, G., and Yoshikawa, T. Serum dehydroepiandrosterone sulfate concentration and carotid atherosclerosis in men with type 2 diabetes. Atherosclerosis 2005;181(2):339-344. View abstract.
Gaby AR. Dehydroepiandrosterone: biological effects and clinical significance. Alt Med Rev 1996;1(2):60-69.
Gill, J., Vythilingam, M., and Page, G. G. Low cortisol, high DHEA, and high levels of stimulated TNF-alpha, and IL-6 in women with PTSD. J Trauma Stress. 2008;21(6):530-539. View abstract.
Giltay, E. J., van Schaardenburg, D., Gooren, L. J., and Dijkmans, B. A. Dehydroepiandrosterone sulfate in patients with rheumatoid arthritis. Ann N.Y.Acad.Sci. 6-22-1999;876:152-154. View abstract.
Gleicher, N., Weghofer, A., and Barad, D. H. Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation. Reprod.Biomed.Online. 2010;21(3):360-365. View abstract.
Gobbi, D., Rhoden, E. L., Menti, E., Lulhier, F., and Rhoden, C. Effects of the chronic use of dehydroepiandrosterone (DHEA) on testicular weight and spermatogenesis: experimental study in rats. Int.Urol.Nephrol. 2003;35(1):119-122. View abstract.
Goldberg, M. Dehydroepiandrosterone, insulin-like growth factor-I, and prostate cancer. Ann Intern Med 10-1-1998;129(7):587-588. View abstract.
Gomez-Santos, C., Larque, E., Granero, E., Hernandez-Morante, J. J., and Garaulet, M. Dehydroepiandrosterone-sulphate replacement improves the human plasma fatty acid profile in plasma of obese women. Steroids 12-11-2011;76(13):1425-1432. View abstract.
Gonzales, G. F., Gasco, M., Tapia, V., and Gonzales-Castaneda, C. High serum testosterone levels are associated with excessive erythrocytosis of chronic mountain sickness in men. Am J Physiol Endocrinol.Metab 2009;296(6):E1319-E1325. View abstract.
Gonzalez, F., Nair, K. S., Daniels, J. K., Basal, E., and Schimke, J. M. Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women. Am J Physiol Endocrinol.Metab 2-1-2012;302(3):E297-E306. View abstract.
Gordon, C. M., Grace, E., Emans, S. J., Goodman, E., Crawford, M. H., and Leboff, M. S. Changes in bone turnover markers and menstrual function after short- term oral DHEA in young women with anorexia nervosa. J Bone Miner.Res. 1999;14(1):136-145. View abstract.
Brown, G. A., Vukovich, M. D., Sharp, R. L., Reifenrath, T. A., Parsons, K. A., and King, D. S. Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men. J Appl.Physiol 1999;87(6):2274-2283. View abstract.
Bruyn GW and DeJong FH. Dehydroepiandrosterone-sulfate and Huntington's chorea. Advances in Neurology 1973;1:553-555.
Brzoza, Z., Kasperska-Zajac, A., Badura-Brzoza, K., Matysiakiewicz, J., Hese, R. T., and Rogala, B. Decline in dehydroepiandrosterone sulfate observed in chronic urticaria is associated with psychological distress. Psychosom.Med 2008;70(6):723-728. View abstract.
Buffington, C. K., Pourmotabbed, G., and Kitabchi, A. E. Case report: amelioration of insulin resistance in diabetes with dehydroepiandrosterone. Am J Med Sci. 1993;306(5):320-324. View abstract.
Buford, T. W. and Willoughby, D. S. Impact of DHEA(S) and cortisol on immune function in aging: a brief review. Appl.Physiol Nutr Metab 2008;33(3):429-433. View abstract.
Burger, H. G., Dudley, E. C., Cui, J., Dennerstein, L., and Hopper, J. L. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin.Endocrinol.Metab 2000;85(8):2832-2838. View abstract.
Buster, J. E., Casson, P. R., Straughn, A. B., Dale, D., Umstot, E. S., Chiamori, N., and Abraham, G. E. Postmenopausal steroid replacement with micronized dehydroepiandrosterone: preliminary oral bioavailability and dose proportionality studies. Am J Obstet Gynecol 1992;166(4):1163-1170. View abstract.
Butterworth, R. F., Lalonde, R., Power, C., Baker, G. B., Gamrani, H., and Ahboucha, S. Dehydroepiandrosterone sulphate improves cholestasis-associated fatigue in bile duct ligated rats. Neurogastroenterol.Motil. 2009;21(12):1319-1325. View abstract.
Calvo, E., Luu-The, V., Morissette, J., Martel, C., Labrie, C., Bernard, B., Bernerd, F., Deloche, C., Chaussade, V., Leclaire, J., and Labrie, F. Pangenomic changes induced by DHEA in the skin of postmenopausal women. J Steroid Biochem Mol.Biol. 2008;112(4-5):186-193. View abstract.
Cappola, A. R., O'Meara, E. S., Guo, W., Bartz, T. M., Fried, L. P., and Newman, A. B. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study. J Gerontol.A Biol.Sci Med Sci 2009;64(12):1268-1274. View abstract.
Carlsen, S. M., Romundstad, P., and Jacobsen, G. Early second-trimester maternal hyperandrogenemia and subsequent preeclampsia: a prospective study. Acta Obstet Gynecol.Scand. 2005;84(2):117-121. View abstract.
Casson PR, Buster JE, Lindsay MS, and et al. Dehydroepiandrosterone (DHEA) supplementation augments ovulation induction (OI) in poor responders: a case series [abstract]. Fertility and Sterility 1998;70(2S)(Suppl 1):475S-476S.
Casson, P. R., Lindsay, M. S., Pisarska, M. D., Carson, S. A., and Buster, J. E. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Hum.Reprod. 2000;15(10):2129-2132. View abstract.
Casson, P. R., Straughn, A. B., Umstot, E. S., Abraham, G. E., Carson, S. A., and Buster, J. E. Delivery of dehydroepiandrosterone to premenopausal women: effects of micronization and nonoral administration. Am J Obstet Gynecol 1996;174(2):649-653. View abstract.
Chang DM, Lan H, Lan HY, and et al. GL701 (Prasterone, DHEA) significantly reduces flares in female patients with mild to moderate systemic lupus erythematosus. Arthritis Rheum 2000;43(suppl):S241.
Chang, D. M., Lan, J. L., Lin, H. Y., and Luo, S. F. Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002;46(11):2924-2927. View abstract.
Charlton, M., Angulo, P., Chalasani, N., Merriman, R., Viker, K., Charatcharoenwitthaya, P., Sanderson, S., Gawrieh, S., Krishnan, A., and Lindor, K. Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease. Hepatology 2008;47(2):484-492. View abstract.
Chassany, O. [Does dehydroepiandrosterone improve well-being?]. Presse Med 7-8-2000;29(24):1354-1355. View abstract.
Chen, H., Lin, A. S., Li, Y., Reiter, C. E., Ver, M. R., and Quon, M. J. Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion. J Biol.Chem 10-24-2008;283(43):29228-29238. View abstract.
Chen, M. J., Chen, C. D., Yang, J. H., Chen, C. L., Ho, H. N., Yang, W. S., and Yang, Y. S. High serum dehydroepiandrosterone sulfate is associated with phenotypic acne and a reduced risk of abdominal obesity in women with polycystic ovary syndrome. Hum.Reprod. 2011;26(1):227-234. View abstract.
Chen, Y. C., Chang, H. H., Wen, C. J., Lin, W. Y., Chen, C. Y., Hong, B. S., and Huang, K. C. Elevated serum dehydroepiandrosterone sulphate level correlates with increased risk for metabolic syndrome in the elderly men. Eur J Clin Invest 2010;40(3):220-225. View abstract.
Cho, S. H., Choi, M. H., Sim, W. Y., Lee, W. Y., and Chung, B. C. Metabolic alterations of DHEA and cholesterol sulphates in the hair of patients with acne measured by liquid chromatography-mass spectrometry. Exp.Dermatol. 7-1-2010;19(7):694-696. View abstract.
Christiansen, J. J., Gravholt, C. H., Fisker, S., Moller, N., Andersen, M., Svenstrup, B., Bennett, P., Ivarsen, P., Christiansen, J. S., and Jorgensen, J. O. Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism. Eur J Endocrinol. 2005;152(1):77-85. View abstract.
Ciotta, L., Calogero, A. E., Farina, M., De, Leo, V, La Marca, A., and Cianci, A. Clinical, endocrine and metabolic effects of acarbose, an alpha- glucosidase inhibitor, in PCOS patients with increased insulin response and normal glucose tolerance. Hum Reprod. 2001;16(10):2066-2072. View abstract.
Colker C, Torina G, Swain M, and et al. Double-blind, placebo-controlled, randomized clinical trial evaluating the effects of exercise plus 3-Acetyl-7-oxo-dehydroepiandrosterone on body composition and the endocrine system in overweight adults [abstract]. Journal of Exercise Physiology 1999;2(4)
Corrigan, A. B. Dehydroepiandrosterone and sport. Med J Aust 8-16-1999;171(4):206-208. View abstract.
Danenberg, H. D., Alpert, G., Lustig, S., and Ben Nathan, D. Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production. Antimicrob Agents Chemother 1992;36(10):2275-2279. View abstract.
Danenberg, H. D., Ben-Yehuda, A., Zakay-Rones, Z., Gross, D. J., and Friedman, G. Dehydroepiandrosterone treatment is not beneficial to the immune response to influenza in elderly subjects. J Clin.Endocrinol.Metab 1997;82(9):2911-2914. View abstract.
Davis, S. R., Panjari, M., and Stanczyk, F. Z. Clinical review: DHEA replacement for postmenopausal women. J Clin Endocrinol.Metab 2011;96(6):1642-1653. View abstract.
Davis, S. R., Shah, S. M., McKenzie, D. P., Kulkarni, J., Davison, S. L., and Bell, R. J. Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol.Metab 2008;93(3):801-808. View abstract.
Daynes, R. A., Dudley, D. J., and Araneo, B. A. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells. Eur.J Immunol 1990;20(4):793-802. View abstract.
de la, Torre B., Hedman, M., Nilsson, E., Olesen, O., and Thorner, A. Relationship between blood and joint tissue DHEAS levels in rheumatoid arthritis and osteoarthritis. Clin Exp Rheumatol. 1993;11(6):597-601. View abstract.
Defay, R., Pinchinat, S., Lumbroso, S., Sultan, C., Papoz, L., and Delcourt, C. Relationships between hormonal status and cataract in french postmenopausal women: the POLA study. Ann.Epidemiol. 2003;13(9):638-644. View abstract.
Devogelaer, J. P., Crabbe, J., and de Deuxchaisnes. Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass. Br.Med J (Clin.Res.Ed) 3-28-1987;294(6575):798-800. View abstract.
Dhatariya, K. Dehydroepiandrosterone sulfate has not been substantiated as an anabolic hormone. Arch.Intern.Med 7-14-2008;168(13):1470. View abstract.
Dhatariya, K., Bigelow, M. L., and Nair, K. S. Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes 2005;54(3):765-769. View abstract.
Diamond, P., Cusan, L., Gomez, J. L., Belanger, A., and Labrie, F. Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women. J Endocrinol 1996;150 Suppl:S43-S50. View abstract.
Divasta, A. D., Feldman, H. A., Giancaterino, C., Rosen, C. J., Leboff, M. S., and Gordon, C. M. The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa. Metabolism 2012;61(7):1010-1020. View abstract.
Dolecek, R., Tymonova, J., Adamkova, M., Kadlcik, M., Pohlidal, A., and Zavodna, R. Endocrine changes after burns: the bone involvement. Acta Chir Plast. 2003;45(3):95-103. View abstract.
Dorner, G., Gotz, F., Rohde, W., Plagemann, A., Lindner, R., Peters, H., and Ghanaati, Z. Genetic and epigenetic effects on sexual brain organization mediated by sex hormones. Neuroendocrinol.Lett 2001;22(6):403-409. View abstract.
Dunn, P. J., Mahood, C. B., Speed, J. F., and Jury, D. R. Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. N.Z.Med J 11-28-1984;97(768):805-808. View abstract.
Dyner T, Lang W, Geaga JV, and et al. Phase I study of dehydroepiandrosterone (EL-10) therapy in symptomatic HIV disease [abstract]. 6th Intl Conf on AIDS 1990;3:208 .
El-Alfy, M., Deloche, C., Azzi, L., Bernard, B. A., Bernerd, F., Coutet, J., Chaussade, V., Martel, C., Leclaire, J., and Labrie, F. Skin responses to topical dehydroepiandrosterone: implications in antiageing treatment? Br.J Dermatol. 2010;163(5):968-976. View abstract.
Elekima, O. T., Mills, C. O., Ahmad, A., Skinner, G. R., Ramsden, D. B., Bown, J., Young, T. W., and Elias, E. Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases. Liver 2000;20(1):45-50. View abstract.
Enomoto, M., Adachi, H., Fukami, A., Furuki, K., Satoh, A., Otsuka, M., Kumagae, S., Nanjo, Y., Shigetoh, Y., and Imaizumi, T. Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow-up study in a community-based cohort (Tanushimaru study). J Am Geriatr.Soc 2008;56(6):994-998. View abstract.
Estabrook, R. W., Milewich, L., and Prough, R. A. Cytochrome P-450s as toxicogenic catalysts: the influence of dehydroepiandrosterone. Princess Takamatsu Symp. 1990;21:33-44. View abstract.
Farah, M. J., Givens, J. R., and Kitabchi, A. E. Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans. J Clin Endocrinol Metab 1990;70(4):1075-1081. View abstract.
Feldman, H. A., Johannes, C. B., McKinlay, J. B., and Longcope, C. Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study. Ann Epidemiol. 1998;8(4):217-228. View abstract.
Dorgan, J. F., Reichman, M. E., Judd, J. T., Brown, C., Longcope, C., Schatzkin, A., Forman, M., Campbell, W. S., Franz, C., Kahle, L., Taylor, P. R. Relation of energy, fat, and fiber intakes to plasma concentrations of estrogens and androgens in premenopausal women. Am J Clin Nutr 1996;64(1):25-31. View abstract.
Dumas de La Roque, E., Savineau, J. P., Metivier, A. C., Billes, M. A., Kraemer, J. P., Doutreleau, S., Jougon, J., Marthan, R., Moore, N., Fayon, M., Baulieu, E. E., Dromer, C. Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): a pilot study. Ann Endocrinol (Paris) 2012;73(1):20-2. View abstract.
Dyner TS, Lang W, Geaga J, et al. An open-label, dose-escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. J Acquir Immune Defic Syndr 1993;6:459-65. View abstract.
Ebeling P, Koivisto VA. Physiological importance of dehydroepiandrosterone. Lancet 1994;343:1479-81. View abstract.
Elraiyah T, Sonbol MB, Wang Z, et al. Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis. J Clin Endocrinol Metab 2014;99(10):3536-42. View abstract.
Fassati, P., Fassati, M., Sonka, J., Lesensky, K. [New approach to the treatment of angina pectoris by dehydroepiandrosterone-sulfate]. Cas Lek Cesk 1971;110(26):606-9. View abstract.
Fassati, P., Fassati, M., Sonka, J., Lesensky, K. Dehydroepiandrosterone sulphate--a new approach to some cases of angina pectoris therapy. Agressologie 1970;11(5):445-8. View abstract.
FDA News Release: FDA approves Intrarosa for postmenopausal women experiencing pain during sex. FDA Press Announcements, November 17, 2016. Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm529641.htm.
Finckh, A., Berner, I. C., Aubry-Rozier, B., So, A. K. A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia. J Rheumatol 2005;32(7):1336-40. View abstract.
Fischer, L., Mahoney, C., Jeffcoat, A. R., Koch, M. A., Thomas, B. E., Valentine, J. L., Stinchcombe, T., Boan, J., Crowell, J. A., Zeisel, S. H. Clinical characteristics and pharmacokinetics of purified soy isoflavones: multiple-dose administration to men with prostate neoplasia. Nutr Cancer 2004;48(2):160-70. View abstract.
Flynn MA, Weaver-Osterholtz D, Sharpe-Timms KL, et al. Dehydroepiandrosterone replacement in aging humans. [Abstract] J Clin Endocrinol Metab 1999;84:1527-33. View abstract.
Forrest AD, Drewery J, Fotherby K, Laverty SG. A clinical trial of dehydroepiandrosterone (Diandrone). J Neurol Neurosurg Psychiat 1960;23:52-5. View abstract.
Forsblad-d'Elia, H., Carlsten, H., Labrie, F., Konttinen, Y. T., Ohlsson, C. Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. J Clin Endocrinol Metab 2009;94(6):2044-51. View abstract.
Foth D, Nawroth F. Effect of soy supplementation on endogenous hormones in postmenopausal women. Gynecol Obstet Invest 2003;55:135-8. View abstract.
Freeland-Graves JH, Lin PH. Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. J Am Coll Nutr 1991;10:38-43. View abstract.
Frye RF, Kroboth PD, Folan MM, et al. Effect of DHEA on CYP3A-mediated metabolism of triazolam. Clin Pharmacol Ther 2000;67:109 (abstract PI-82).
Gebre-Medhin, G., Husebye, E. S., Mallmin, H., Helstrom, L., Berne, C., Karlsson, F. A., Kampe, O. Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease. Clin Endocrinol (Oxf) 2000;52(6):775-80. View abstract.
Genazzani AD, Stomati M, Bernardi F, et al. Long-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids. Fertil Steril 2003;80:1495-501. View abstract.
Genazzani AD, Stomati M, Strucchi C, et al. Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Fertil Steril 2001;76:241-8. View abstract.
Genazzani, A. R., Inglese, S., Lombardi, I., Pieri, M., Bernardi, F., Genazzani, A. D., Rovati, L., Luisi, M. Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency. Aging Male 2004;7(2):133-43. View abstract.
Genazzani, A. R., Stomati, M., Valentino, V., Pluchino, N., Pot, E., Casarosa, E., Merlini, S., Giannini, A., Luisi, M. Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality. Climacteric 2011;14(6):661-8. View abstract.
Genelabs Technologies, Inc. Prestara Background. Available at: https://www.genelabs.com/development/prestaraBackground.html (Accessed 10 December 2004).
Giltay, E. J., van Schaardenburg, D., Gooren, L. J., von Blomberg, B. M., Fonk, J. C., Touw, D. J., Dijkmans, B. A. Effects of dehydroepiandrosterone administration on disease activity in patients with rheumatoid arthritis. Br J Rheumatol 1998;37(6):705-6. View abstract.
Gleicher, N., Ryan, E., Weghofer, A., Blanco-Mejia, S., Barad, D. H. Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study. Reprod Biol Endocrinol 2009;7-108. View abstract.
Goldbeck L, Schmid K. Effectiveness of autogenic relaxation training on children and adolescents with behavioral and emotional problems. J Am Acad Child Adolesc Psychiatry 2003;42(9):1046-54. View abstract.
Goldin, B. R., Brauner, E., Adlercreutz, H., Ausman, L. M., Lichtenstein, A. H. Hormonal response to diets high in soy or animal protein without and with isoflavones in moderately hypercholesterolemic subjects. Nutr Cancer 2005;51(1):1-6. View abstract.
Gomez-Santos, C., Hernandez-Morante, J. J., Tebar, F. J., Granero, E., Garaulet, M. Differential effect of oral dehydroepiandrosterone-sulphate on metabolic syndrome features in pre- and postmenopausal obese women. Clin Endocrinol (Oxf) 2012;77(4):548-54. View abstract.
Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
Gordon CM, Grace E, Emans SJ, et al. Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial. J Clin Endocrinol Metab 2002;87:4935-41. View abstract.
Gravisse N, Vibarel-Rebot N, Labsy Z, et al. Short-term dehydroepiandrosterone intake and supramaximal exercise in young recreationally-trained women. Int J Sports Med. 2018;39(9):712-719. View abstract.
Grimley Evans J, Malouf R, Huppert F, van Niekerk JK. Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people. Cochrane Database Syst Rev 2006;CD006221. View abstract.
Guay, A. T. Decreased testosterone in regularly menstruating women with decreased libido: a clinical observation. J Sex Marital Ther 2001;27(5):513-9. View abstract.
Gurnell, E. M., Hunt, P. J., Curran, S. E., Conway, C. L., Pullenayegum, E. M., Huppert, F. A., Compston, J. E., Herbert, J., Chatterjee, V. K. Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. J Clin Endocrinol Metab 2008;93(2):400-9. View abstract.
Hackbert L, Heiman JR. Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. J Womens Health Gend Based Med 2002;11:155-62.. View abstract.
Hartkamp, A., Geenen, R., Godaert, G. L., Bijl, M., Bijlsma, J. W., Derksen, R. H. Effects of dehydroepiandrosterone on fatigue and well-being in women with quiescent systemic lupus erythematosus: a randomised controlled trial. Ann Rheum Dis 2010;69(6):1144-7. View abstract.
Hartkamp, A., Geenen, R., Godaert, G. L., Bijl, M., Bijlsma, J. W., Derksen, R. H. The effect of dehydroepiandrosterone on lumbar spine bone mineral density in patients with quiescent systemic lupus erythematosus. Arthritis Rheum 2004;50(11):3591-95. View abstract.
Hartkamp, A., Geenen, R., Godaert, G. L., Bootsma, H., Kruize, A. A., Bijlsma, J. W., Derksen, R. H. Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled trial. Ann Rheum Dis 2008;67(1):91-7. View abstract.
Hayashi T, Teiji Esaki T, Emiko Muto E, et al. Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide. Arterioscler Thromb Vasc Biol 2000;20:782-92. View abstract.
Henderson E, Yang JY, Schwartz A. Dehydroepiandrosterone (DHEA) and synthetic DHEA analogs are modest inhibitors of HIV-1 IIIB replication. AIDS Res Hum Retroviruses 1992;8:625-31. View abstract.
Himmel PB, Seligman TM. A Pilot Study Employing Dehydroepiandrosterone (DHEA) in the Treatment of Chronic Fatigue Syndrome. [Abstract]. J Clin Rheumatol 1999:5:56-9. View abstract.
Hirshman, E., Wells, E., Wierman, M. E., Anderson, B., Butler, A., Senholzi, M., Fisher, J. The effect of dehydroepiandrosterone (DHEA) on recognition memory decision processes and discrimination in postmenopausal women. Psychon Bull Rev 2003;10(1):125-34. View abstract.
Holzmann, H., Morsches, B., Krapp, R., Hoede, N., Oertel, G. W. [Therapy of psoriasis with dehydroepiandrosterone-enanthate. II. Intramuscular depot application of 300 mg weekly (author's transl)]. Archiv fur Dermatol Forsch 1973;247(1):23-8. View abstract.
Hunt PJ, Gurnell EM, Huppert FA, et al. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000;85:4650-6.. View abstract.
Huppert, F. A., Van Niekerk, J. K. Dehydroepiandrosterone (DHEA) supplementation for cognitive function (Cochrane Review). Cochrane Database (Issue 2) 2001;2:CD000304. View abstract.
Igwebuike, A., Irving, B. A., Bigelow, M. L., Short, K. R., McConnell, J. P., Nair, K. S. Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women. J Clin Endocrinol Metab 2008;93(2):534-8. View abstract.
Ishikawa, M., Shimizu, T. Dehydroepiandrosterone sulfate and induction of labor. Am J Perinatol 1989;6(2):173-5. View abstract.
Jacobson MA, Fusaro RE, Galmarini M, Lang W. Decreased serum dehydroepiandrosterone is associated with an increased progression of human immunodeficiency virus infection in men with CD4 cell counts of 200-499. J Infect Dis 1991;164:864-8. View abstract.
Jankowski, C. M., Gozansky, W. S., Kittelson, J. M., Van Pelt, R. E., Schwartz, R. S., Kohrt, W. M. Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens. J Clin Endocrinol Metab 2008;93(12):4767-73. View abstract.
Jankowski, C. M., Gozansky, W. S., Schwartz, R. S., Dahl, D. J., Kittelson, J. M., Scott, S. M., Van Pelt, R. E., Kohrt, W. M. Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. J Clin Endocrinol Metab 2006;91(8):2986-93. View abstract.
Jankowski, C. M., Gozansky, W. S., Van Pelt, R. E., Wolfe, P., Schwartz, R. S., Kohrt, W. M. Oral dehydroepiandrosterone replacement in older adults: effects on central adiposity, glucose metabolism and blood lipids. Clin Endocrinol (Oxf) 2011;75(4):456-63. View abstract.
Janssen K, Mensink RP, Cox FJ, et al. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Am J Clin Nutr 1998;67:255-62. View abstract.
Jarrar D, Wang P, Cioffi WG, et al. Mechanisms of the salutary effects of dehydroepiandrosterone after trauma-hemorrhage. Direct or indirect effects on cardiac and hepatocellular functions? Arch Surg 2000;135:416-23. View abstract.
Jesse, R. L., Loesser, K., Eich, D. M., Qian, Y. Z., Hess, M. L., Nestler, J. E. Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo. Ann N.Y.Acad Sci 1995;774:281-90. View abstract.
Johannsson G, Burman P, Wiren L, et al. Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial. J Clin Endocrinol Metab 2002;87:2046-52. View abstract.
Kara M, Aydin T, Aran T, et al. Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve? Eur J Obstet Gynecol Reprod Biol 2014;173:63-5. View abstract.
Kawano, H., Yasue, H., Kitagawa, A., Hirai, N., Yoshida, T., Soejima, H., Miyamoto, S., Nakano, M., Ogawa, H. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab 2003;88(7):3190-95. View abstract.
Kenny, A. M., Boxer, R. S., Kleppinger, A., Brindisi, J., Feinn, R., Burleson, J. A. Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women. J Am Geriatr Soc 2010;58(9):1707-14. View abstract.
Kim SS, Brody KH. Dehydroepiandrosterone replacement in Addison's disease. Eur J Obstet Gynecol Reprod Biol 2001;97:96-7. View abstract.
Kline MD, Jaggers ED. Mania onset while using dehydroepiandrosterone (letter). Am J Psychiatry 1999;156:971. View abstract.
Klove, K. L., Roy, S., Lobo, R. A. The effect of different contraceptive treatments on the serum concentration of dehydroepiandrosterone sulfate. Contraception 1984;29(4):319-24. View abstract.
Kochan Z, Karbowska J. Dehydroepiandrosterone up-regulates resistin gene expression in white adipose tissue. Mol Cell Endocrinol 2004;218:57-64. View abstract.
Kokoska L, Polesny Z, Rada V, et al. Screening of some Siberian medicinal plants for antimicrobial activity. J Ethnopharmacol 2002;82:51-3. View abstract.
Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995;346:270-4. View abstract.
Kritz-Silverstein, D., von, Muhlen D., Laughlin, G. A., Bettencourt, R. Effects of dehydroepiandrosterone supplementation on cognitive function and quality of life: the DHEA and Well-Ness (DAWN) Trial. J Am Geriatr Soc 2008;56(7):1292-8. View abstract.
Kroboth PD, Salek FS, Pittenger AL, et al. DHEA and DHEA-S: A review. J Clin Pharmacol 1999;39:327-48. View abstract.
Krysiak R, Szkróbka W, Okopien B. Impact of dehydroepiandrosterone on thyroid autoimmunity and function in men with autoimmune hypothyroidism. Int J Clin Pharm 2021;43(4):998-1005. View abstract.
Kudielka BM, Hellhammer J, Hellhammer D, et al. Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2 week dehydroepiandrosterone treatment. [Abstract] J Clin Endocrinol Metab 1998;83:1756-61. View abstract.
Kuratsune H, Yamaguti K, Sawada M, et al. Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome. Int J Mol Med 1998;1:143-6. View abstract.
Kuritzky L. DHEA: Science or wishful thinking? Hosp Pract 1998;33:85-6. View abstract.
Labrie F, Diamond P, Cusan L, et al. Effect of 12 month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J Clin Endocrinol Metab 1997;82:3498-505. View abstract.
Labrie, F., Archer, D. F., Bouchard, C., Fortier, M., Cusan, L., Gomez, J. L., Girard, G., Baron, M., Ayotte, N., Moreau, M., Dube, R., Cote, I., Labrie, C., Lavoie, L., Berger, L., Gilbert, L., Martel, C., Balser, J. Intravaginal dehydroepiandrosterone (prasterone), a highly efficient treatment of dyspareunia. Climacteric 2011;14(2):282-8. View abstract.
Labrie, F., Archer, D., Bouchard, C., Fortier, M., Cusan, L., Gomez, J. L., Girard, G., Baron, M., Ayotte, N., Moreau, M., Dube, R., Cote, I., Labrie, C., Lavoie, L., Berger, L., Gilbert, L., Martel, C., Balser, J. Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy. Menopause 2009;16(5):907-22. View abstract.
Labrie, F., Archer, D., Bouchard, C., Fortier, M., Cusan, L., Gomez, J. L., Girard, G., Baron, M., Ayotte, N., Moreau, M., Dube, R., Cote, I., Labrie, C., Lavoie, L., Berger, L., Martel, C., Balser, J. High internal consistency and efficacy of intravaginal DHEA for vaginal atrophy. Gynecol Endocrinol 2010;26(7):524-32. View abstract.
Lasco A, Frisina N, Morabito N, et al. Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. Eur J Endocrinol 2001;145:457-61.. View abstract.
Lauritzen, C. [Therapeutic attempts with dehydroepiandrosterone sulfate in threatened pregnancies]. Arch Gynakol 1971;211(1):247-9. View abstract.
Legrain S, Massien C, Lahlou N, et al. Dehydroepiandrosterone replacement administration: pharmacokinetic and pharmacodynamic studies in healthy elderly subjects. J Clin Endocrinol Metab 2000;85:3208-17. View abstract.
Li J, Yuan H, Chen Y, Wu H, Wu H, Li L. A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection. Int J Gynaecol Obstet 2015;131(3):240-5. View abstract.
Li Y, Ren J, Li N, et al. A dose-response and meta-analysis of dehydroepiandrosterone (DHEA) supplementation on testosterone levels: perinatal prediction of randomized clinical trials. Exp Gerontol 2020;141:111110. Online ahead of print. View abstract.
Liao YH, Liao KF, Kao CL, et al. Effect of dehydroepiandrosterone administration on recovery from mix-type exercise training-induced muscle damage. Eur J Appl Physiol 2013;113(1):99-107. View abstract.
Libe, R., Barbetta, L., Dall'Asta, C., Salvaggio, F., Gala, C., Beck-Peccoz, P., Ambrosi, B. Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. J Endocrinol Invest 2004;27(8):736-41. View abstract.
Lin H, Li L, Wang Q, Wang Y, Wang J, Long X. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA supplementation of bone mineral density in healthy adults. Gynecol Endocrinol. 2019;35(11):924-31. View abstract.
Lovas, K., Gebre-Medhin, G., Trovik, T. S., Fougner, K. J., Uhlving, S., Nedrebo, B. G., Myking, O. L., Kampe, O., Husebye, E. S. Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial. J Clin Endocrinol Metab 2003;88(3):1112-18. View abstract.
Maayan, R., Touati-Werner, D., Shamir, D., Yadid, G., Friedman, A., Eisner, D., Weizman, A., Herman, I. The effect of DHEA complementary treatment on heroin addicts participating in a rehabilitation program: a preliminary study. Eur Neuropsychopharmacol 2008;18(6):406-13. View abstract.
Mamas, L., Mamas, E. Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Curr Opin Obstet Gynecol 2009;21(4):306-8. View abstract.
Markowitz JS, Carson WH, Jackson CW. Possible dihydroepiandrosterone-induced mania. Biol Psychiatry 1999;45:241-2. View abstract.
Mazat L, Lafont S, Berr C, et al. Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci U S A 2001;98:8145-50. View abstract.
Mazza E, Maccario M, Ramunni J, et al. Dehydroepiandrosterone sulfate levels in women. Relationships with age, body mass index and insulin levels. (abstract) J Endocrinol Invest 1999;22:681-7. View abstract.
McHenry, C. M., Bell, P. M., Hunter, S. J., Thompson, C. J., Courtney, C. H., Ennis, C. N., Sheridan, B., McCance, D. R., Mullan, K. R., Atkinson, A. B. Effects of dehydroepiandrosterone sulphate (DHEAS) replacement on insulin action and quality of life in hypopituitary females: a double-blind, placebo-controlled study. Clin Endocrinol (Oxf) 2012;77(3):423-9. View abstract.
Mease PJ, Ginzler EM, Gluck OS, et al. Improvement in bone mineral density in steroid-treated SLE patients during treatment with GL701 (prasterone, dehydroepiandrosterone). 2000 American College of Rheumatology Meeting. Philadelphia, PA. October 29-November 2. abstract 835.
Mease PJ, Merrill JT, Lahita RG, et al. GL701 (prasterone, dehydroepiandrosterone) improves systemic lupus erythematosus. 2000 American College of Rheumatology Meeting. Philadelphia, PA. October 29-November 2. Abstract 1230.
Merritt, P., Stangl, B., Hirshman, E., Verbalis, J. Administration of dehydroepiandrosterone (DHEA) increases serum levels of androgens and estrogens but does not enhance short-term memory in post-menopausal women. Brain Res 11-5-2012;1483:54-62. View abstract.
Meston CM, Heiman JR. Acute dehydroepiandrosterone effects on sexual arousal in premenopausal women. J Sex Marital Ther 2002;28:53-60. View abstract.
Mochizuki, M., Honda, T., Deguchi, M., Morikawa, H., Tojo, S. A study on the effect of dehydroepiandrosterone sulfate on so-called cervical ripening. Acta Obstet Gynecol Scand 1978;57(5):397-401. View abstract.
Moffat SD, Zonderman AB, Harman M, et al. The relationship between longitudinal declines in dehydroepiandrosterone sulfate concentrations and cognitive performance in older men. Arch Int Med 2000;160:2193-8. View abstract.
Morales AJ, Haubrich RH, Hwang JY, et al. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf)1998;49:421-32. View abstract.
Morales, A. J., Nolan, J. J., Nelson, J. C., Yen, S. S. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994;78(6):1360-7. View abstract.
Morales, A., Black, A., Emerson, L., Barkin, J., Kuzmarov, I., Day, A. Androgens and sexual function: a placebo-controlled, randomized, double-blind study of testosterone vs. dehydroepiandrosterone in men with sexual dysfunction and androgen deficiency. Aging Male 2009;12(4):104-12. View abstract.
Moriyama Y, Yasue H, Yoshimura M, et al. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol Metab 2000;85:1834-40. View abstract.
Morris KT, Toth-Fejel S, Schmidt J, et al. High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy. Surgery 2001;130:947-53.. View abstract.
Mortola, J. F. Yen, S. S. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 1990;71(3):696-704. View abstract.
Mulder JW, Frissen PH, Krijnen P, et al. Dehydroepiandrosterone as predictor for progression of AIDS in asymptomatic human immunodeficiency virus-infected men. J Infect Dis 1992;165:413-8. View abstract.
Muller, M., van den Beld, A. W., van der Schouw, Y. T., Grobbee, D. E., Lamberts, S. W. Effects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly men. J Clin Endocrinol Metab 2006;91(10):3988-91. View abstract.
Nagels HE, Rishworth JR, Siristatidis CS, Kroon B. Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. Cochrane Database Syst Rev 2015;(11):CD009749. View abstract.
Nair KS, Rizza RA, O'Brien P, et al. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 2006;355:1647-59. View abstract.
Nasman B, Olsson T, Backstrom T, et al. Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia. Biol Psychiatry 1991;30:684-90. View abstract.
National Collegiate Athletic Association. List of banned drug classes for 2004-2005. Available at: www.ncaa.org.
Ng TB. A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmacol 1998;30:1-4. View abstract.
Panjari, M., Bell, R. J., Jane, F., Wolfe, R., Adams, J., Morrow, C., Davis, S. R. A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido. J Sex Med 2009;6(9):2579-90. View abstract.
Panjari, M., Davis, S. R. DHEA for postmenopausal women: a review of the evidence. Maturitas 2010;66(2):172-9. View abstract.
Parasrampuria J, Schwartz K, Petesch R. Quality control of dehydroepiandrosterone dietary supplement products. JAMA 1998;280:1565. View abstract.
Peixoto C, José Grande A, Gomes Carrilho C, Egidio Nardi A, Cardoso A, Barciela Veras A. Dehydroepiandrosterone for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials. J Neurosci Res 2020;98(12):2510-28. View abstract.
Penisson-Besnier, I., Devillers, M., Porcher, R., Orlikowski, D., Doppler, V., Desnuelle, C., Ferrer, X., Bes, M. C., Bouhour, F., Tranchant, C., Lagrange, E., Vershueren, A., Uzenot, D., Cintas, P., Sole, G., Hogrel, J. Y., Laforet, P., Vial, C., Vila, A. L., Sacconi, S., Pouget, J., Eymard, B., Chevret, S., Annane, D. Dehydroepiandrosterone for myotonic dystrophy type 1. Neurology 2008;71(6):407-12. View abstract.
Pepping J. DHEA: dehydroepiandrosterone. Am J Health Syst Pharm 2000;57:2048-50, 2053-4, 2056. View abstract.
Percheron G, Hogrel JY, Denot-Ledunois S, et al. Effect of 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area: a double-blind placebo-controlled trial. Arch Intern Med 2003;163:720-7.. View abstract.
Persky VW, Turyk ME, Wang L, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75:145-53. View abstract.
Petri MA, Lahita RG, Van Vollenhoven RF, et al. Effects of prasterone on corticosteroid requirements of women with systemic lupus erythematosus: a double-blind, randomized, placebo-controlled trial. Arthritis Rheum 2002;46:1820-9. View abstract.
Petri MA, Mease PJ, Merrill JT, et al. Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus. Arthritis Rheum 2004;50:2858-68. View abstract.
Piketty C, Jayle D, Gonzalez-Canali G, et al. Low plasma levels of dehydroepiandrosterone (DHEA) and incidence of lipodystrophy. HIV Med 2001;2:136-8. View abstract.
Piketty C, Jayle D, Leplege A, et al. Double-blind placebo-controlled trial of oral dehydroepiandrosterone in patients with advanced HIV disease. Clin Endocrinol (Oxf) 2001;55:325-30. View abstract.
Pillemer, S. R., Brennan, M. T., Sankar, V., Leakan, R. A., Smith, J. A., Grisius, M., Ligier, S., Radfar, L., Kok, M. R., Kingman, A., Fox, P. C. Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjogren's syndrome. Arthritis Rheum 2004;51(4):601-4. View abstract.
Pino JA, Marbot R. Volatile flavor constituents of acerola (Malpighia emarginata DC.) fruit. J Agric Food Chem 2001;49:5880-2. View abstract.
Poretsky, L., Song, L., Brillon, D. J., Ferrando, S., Chiu, J., McElhiney, M., Ferenczi, A., Sison, C., Haller, I., Rabkin, J. Metabolic and hormonal effects of oral DHEA in premenopausal women with HIV infection: a randomized, prospective, placebo-controlled pilot study. Horm Metab Res 2009;41(3):244-9. View abstract.
PremesisRx. Pharmacist's Letter / Prescriber's Letter 1999:15(12);151206.
Prescribing information: Intrarosa (prasterone) vaginal inserts. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208470s000lbl.pdf. Accessed: July 17. 2017
Qin Y, O Santos H, Khani V, Tan SC, Zhi Y. Effects of dehydroepiandrosterone (DHEA) supplementation on the lipid profile: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 2020;30(9):1465-75. View abstract.
Rabijewski, M. Zgliczynski, W. [Dehydroepiandrosterone therapy in men with angiographically verified coronary heart disease: the effects on plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) and fibrinogen plasma concentrations]. Endokrynol Pol 2007;58(3):213-9. View abstract.
Rabijewski, M., Zgliczynski, W. [Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease--preliminary study]. Endokrynol Pol 2005;56(6):904-10. View abstract.
Rabkin JG, Ferrando SJ, Wagner GJ, Rabkin R. DHEA treatment for HIV+ patients: effects on mood, androgenic and anabolic parameters. Psychoneuroendocrinology 2000;25:53-68. View abstract.
Ravindran AV, Balneaves LG, Faulkner G, et al.; CANMAT Depression Work Group. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 5. Complementary and Alternative Medicine Treatments. Can J Psychiatry 2016;61(9):576-87. View abstract.
Reiter WJ, Pycha A, Schatzl G, et al. Serum dehydroepiandrosterone sulfate concentrations in men with erectile dysfunction. Urology 2000;55:755-8. View abstract.
Reiter WJ, Pycha A, Schatzl G, et al. Dehydroepiandosterone in the treatment of erectile dysfunction: A prospective, double-blind, randomized, placebo-controlled study. Urol 1999;53:590-5. View abstract.
Reiter WJ, Schatzl G, Mark I, et al. Dehydroepiandrosterone in the treatment of erectile dysfunction in patients with different organic etiologies. Urol Res 2001;29:278-81. View abstract.
Ritsner, M. S., Gibel, A., Shleifer, T., Boguslavsky, I., Zayed, A., Maayan, R., Weizman, A., Lerner, V. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 2010;71(10):1351-62. View abstract.
Robinzon B, Cutolo M. Should dehydroepiandrosterone replacement therapy be provided with glucocorticoids? Rheumatology (Oxford) 1999;38:488-95. View abstract.
Rosenfield RL. Ovarian and adrenal function in polycystic ovary syndrome. Endocrinol Metab Clin North Am 1999;28:265-93. View abstract.
Rowland NE, Marshall M, Robertson K. Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine. Eur J Pharmacol 2001;419:61-64. View abstract.
Rutkowski K, Sowa P, Rutkowsak-Talipska J, et al. Dehydroepiandrosterone (DHEA): hypes and hopes. Drugs 2014;74(11):1195-207. View abstract.
Sandoughi M, Kaykhaei MA, Langarizadeh E, Dashipour A. Effects of dehydroepiandrosterone on quality of life in premenopausal women with rheumatoid arthritis: a preliminary randomized clinical trial. Int J Rheum Dis 2020. Online ahead of print. View abstracy.
Sasaki, K., Nakano, R., Kadoya, Y., Iwao, M., Shima, K., Sowa, M. Cervical ripening with dehydroepiandrosterone sulphate. Br J Obstet Gynaecol 1982;89(3):195-8. View abstract.
Scarpellini, L., Scarpellini, F., Spina, V. [Clinical evaluation of DHEA-S plasma levels and possible therapeutic value of the hormone in the third trimester]. Clin Ter 1993;143(5):383-8. View abstract.
Schlegel, W., Petersdorf, L. I., Junker, R., Schulte, H., Ebert, C., Von Eckardstein, A. The effects of six months of treatment with a low-dose of conjugated oestrogens in menopausal women. Clin Endocrinol (Oxf) 1999;51(5):643-51. View abstract.
Schmidt, P. J., Daly, R. C., Bloch, M., Smith, M. J., Danaceau, M. A., St Clair, L. S., Murphy, J. H., Haq, N., Rubinow, D. R. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry 2005;62(2):154-62. View abstract.
Shoptaw, S., Majewska, M. D., Wilkins, J., Twitchell, G., Yang, X., Ling, W. Participants receiving dehydroepiandrosterone during treatment for cocaine dependence show high rates of cocaine use in a placebo-controlled pilot study. Exp Clin Psychopharmacol 2004;12(2):126-35. View abstract.
Skolnick AA. Scientific verdict still out on DHEA. JAMA 1996;276:1365-7. View abstract.
Sonmezer, M., Ozmen, B., Cil, A. P., Ozkavukcu, S., Tasci, T., Olmus, H., Atabekoglu, C. S. Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders. Reprod Biomed Online 2009;19(4):508-13. View abstract.
Srinivasan, M., Irving, B. A., Dhatariya, K., Klaus, K. A., Hartman, S. J., McConnell, J. P., Nair, K. S. Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. J Clin Endocrinol Metab 2009;94(3):761-4. View abstract.
Srinivasan, M., Irving, B. A., Frye, R. L., O'Brien, P., Hartman, S. J., McConnell, J. P., Nair, K. S. Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men. J Clin Endocrinol Metab 2010;95(4):1617-25. View abstract.
Stangl, B., Hirshman, E., and Verbalis, J. Administration of dehydroepiandrosterone (DHEA) enhances visual-spatial performance in postmenopausal women. Behav Neurosci 2011;125(5):742-52. View abstract.
Stoll BA. Dietary supplements of dehydroepiandrosterone in relation to breast cancer risk. Eur J Clin Nutr 1999;53:771-5. View abstract.
Stomati M, Monteleone P, Casarosa E, et al. Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol Endocrinol 2000;14:342-63.. View abstract.
Stratigos AJ, Arndt KA, Dover JS. Advances in cutaneous aesthetic surgery. JAMA 1998;280:1397-98. View abstract.
Strous RD, Maayan R, Lapidus R, et al. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry 2003;60:133-41.. View abstract.
Sugino, M., Ohsawa, N., Ito, T., Ishida, S., Yamasaki, H., Kimura, F., Shinoda, K. A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy. Neurology 1998;51(2):586-9. View abstract.
Suh-Burgmann, E., Sivret, J., Duska, L. R., Del Carmen, M., Seiden, M. V. Long-term administration of intravaginal dehydroepiandrosterone on regression of low-grade cervical dysplasia--a pilot study. Gynecol Obstet Invest 2003;55(1):25-31. View abstract.
Sun Y, Mao M, Sun L, et al. Treatment of osteoporosis in men using dehydroepiandrosterone sulfate.Chin Med J (Engl) 2002;115:402-4. View abstract.
Sunderland T, Merril CR, Harrington MG, et al. Reduced plasma dehydroepiandrosterone concentrations in Alzheimer's disease. Lancet 1989;2:570. View abstract.
Talaei A., Amini M., Siavash M., Zare M. The effect of dehydroepiandrosterone on insulin resistance in patients with impaired glucose tolerance. Hormones (Athens) 2010;9(4):326-31. View abstract.
Tchernof A, Labrie F. Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies. Eur J Endocrinol 2004;151:1-14. View abstract.
Teede, H. J., Dalais, F. S., McGrath, B. P. Dietary soy containing phytoestrogens does not have detectable estrogenic effects on hepatic protein synthesis in postmenopausal women. Am J Clin Nutr 2004;79(3):396-401. View abstract.
Thompson RD, Carlson M, Thompson RD, Carlson M. Liquid chromatographic determination of dehydroepiandrosterone (DHEA) in dietary supplement products. J AOAC Int 2000;83:847-57. View abstract.
Tilvis RS, Kahonen M, Harkonen M. Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population. (abstract) Aging (Milano) 1999;11:30-4. View abstract.
Tivesten A, Vandenput L, Carlzon D, et al. Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men. J Am Coll Cardiol 2014;64(17):1801-10. View abstract.
Usiskin K. S., Butterworth S., Clore J. N., Arad Y., Ginsberg H. N., Blackard W. G., Nestler J. E. Lack of effect of dehydroepiandrosterone in obese men. Int J Obes 1990;14(5):457-63. View abstract.
Vacheron-Trystram, M. N., Cheref, S., Gauillard, J., Plas, J. [A case report of mania precipitated by use of DHEA]. Encephale 2002;28(6 Pt 1):563-6. View abstract.
van Thiel, S. W., Romijn, J. A., Pereira, A. M., Biermasz, N. R., Roelfsema, F., van Hemert, A., Ballieux, B., Smit, J. W. Effects of dehydroepiandrostenedione, superimposed on growth hormone substitution, on quality of life and insulin-like growth factor I in patients with secondary adrenal insufficiency: a randomized, placebo-controlled, cross-over trial. J Clin Endocrinol Metab 2005;90(6):3295-3303. View abstract.
van Vollenhoven RF, Engleman EG, McGuire JL. Dehydroepiandrosterone in systemic lupus erythematosus. Arthritis Rheum 1994;37:1305-10. View abstract.
Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31. View abstract.
Van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol 1998;25:285-9. View abstract.
van Vollenhoven RF, Park JL, Genovese MC, et al. A double-blind, placebo-controlled, clinical trial of dehydroepiandrosterone in severe lupus erythematosus. Lupus 1999;8:181-7. View abstract.
van Vollenhoven RF. Dehydroepiandrosterone in systemic lupus erythematosus. Rheum Dis Clin North Am 2000;26:349-62. View abstract.
Vierck JL, Icenoggle DL, Bucci L, Dodson MV. The effects of ergogenic compounds on myogenic satellite cells. Med Sci Sports Exerc 2003;35:769-76. View abstract.
Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf) 2000;53:561-8. View abstract.
Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.JAMA 2004;292:2243-8. View abstract.
Virkki, L. M., Porola, P., Forsblad-d'Elia, H., Valtysdottir, S., Solovieva, S. A., Konttinen, Y. T. Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjogren's syndrome. Arthritis Care Res (Hoboken) 2010;62(1):118-24. View abstract.
Vogiatzi, M. G., Boeck, M. A., Vlachopapadopoulou, E., el-Rashid, R., New, M. I. Dehydroepiandrosterone in morbidly obese adolescents: effects on weight, body composition, lipids, and insulin resistance. Metabolism 1996;45(8):1011-5. View abstract.
von Muhlen D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. Osteoporos Int 2008;19(5):699-707. View abstract.
Wallace MB, Lim J, Cutler A, Bucci L. Effects of dehydroepiandrosterone vs androstenedione supplementation in men. Med Sci Sports Exerc 1999;31:1788-92. View abstract.
Wang X, Feng H, Fan D, Zou G, Han Y, Liu L. The influence of dehydroepiandrosterone (DHEA) on fasting plasma glucose, insulin levels and insulin resistance (HOMA-IR) index: A systematic review and dose response meta-analysis of randomized controlled trials. Complement Ther Med 2020;55:102583. View abstract.
Wang, C., Catlin, D. H., Starcevic, B., Heber, D., Ambler, C., Berman, N., Lucas, G., Leung, A., Schramm, K., Lee, P. W., Hull, L., Swerdloff, R. S. Low-fat high-fiber diet decreased serum and urine androgens in men. J Clin Endocrinol Metab 2005;90(6):3550-9. View abstract.
Weiss, E. P., Shah, K., Fontana, L., Lambert, C. P., Holloszy, J. O., Villareal, D. T. Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone. Am J Clin Nutr 2009;89(5):1459-67. View abstract.
Weiss, E. P., Villareal, D. T., Ehsani, A. A., Fontana, L., Holloszy, J. O. Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness. Aging Cell 2012;11(5):876-84. View abstract.
White, T., Jain, J. K., Stanczyk, F. Z. Effect of oral versus transdermal steroidal contraceptives on androgenic markers. Am J Obstet Gynecol 2005;192(6):2055-9. View abstract.
Wiser, A., Gonen, O., Ghetler, Y., Shavit, T., Berkovitz, A., Shulman, A. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod 2010;25(10):2496-2500. View abstract.
Wit JM, Langenhorst VJ, Jansen M, et al. Dehydroepiandrosterone sulfate treatment for atrichia pubis. Horm Res 2001;56:134-9.. View abstract.
Wolf OT, Neumann O, Hellhammer DH, et al. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab 1997;82:2363-7. View abstract.
Wolf, O. T., Koster, B., Kirschbaum, C., Pietrowsky, R., Kern, W., Hellhammer, D. H., Born, J., Fehm, H. L. A single administration of dehydroepiandrosterone does not enhance memory performance in young healthy adults, but immediately reduces cortisol levels. Biol Psychiatry 1997;42(9):845-8. View abstract.
Wolkowitz OM, Kramer JH, Reus VI, et al. DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Neurology 2003;60:1071-6. . View abstract.
Wolkowitz OM, Reus VI, Keebler A, et al. Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry 1999;156:646-9. View abstract.
Wolkowitz OM, Reus VI, Manfredi F, et al. Dehydroepiandrosterone (DHEA) treatment of depression. [Abstract] Biol Psychiatry 1997;41:311-8. View abstract.
Wolkowitz, O. M., Reus, V. I., Roberts, E., Manfredi, F., Chan, T., Ormiston, S., Johnson, R., Canick, J., Brizendine, L., Weingartner, H. Antidepressant and cognition-enhancing effects of DHEA in major depression. Ann N Y Acad Sci 1995;774:337-9. View abstract.
Wu TT, Chen Y, Zhou Y, et al. Prognostic value of dehydroepiandrosterone sulfate for patients with cardiovascular disease: a systematic review and meta-analysis. J Am Heart Assoc 2017;6(5). pii: e004896. View abstract.
Yamada, S., Akishita, M., Fukai, S., Ogawa, S., Yamaguchi, K., Matsuyama, J., Kozaki, K., Toba, K., Ouchi, Y. Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment. Geriatr Gerontol Int 2010;10(4):280-7. View abstract.
Yen SS, Morales AJ, Khorram O. Replacement of DHEA in aging men and women. Potential remedial effects. Ann N Y Acad Sci 1995;774:128-42. View abstract.
Yeung TW, Chai J, Li RH, et al. A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertil Steril 2014;102(1):108-115.e1. View abstract.
Yeung, T. W., Li, R. H., Lee, V. C., Ho, P. C., Ng, E. H. A randomized double-blinded placebo-controlled trial on the effect of dehydroepiandrosterone for 16 weeks on ovarian response markers in women with primary ovarian insufficiency. J Clin Endocrinol Metab 2013;98(1):380-8. View abstract.
Zhang M, Niu W, Wang Y, et al. Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis. J Assist Reprod Genet 2016;33(8):981-91. View abstract.
Zhu Y, Qiu L, Jiang F, et al. The effect of dehydroepiandrosterone (DHEA) supplementation on estradiol levels in women: A dose-response and meta-analysis of randomized clinical trials. Steroids 2021;173:108889. View abstract.
Abraham, G. E. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin.Endocrinol.Metab 1974;39(2):340-346. View abstract.
Acosta, E. G., Bruttomesso, A. C., Bisceglia, J. A., Wachsman, M. B., Galagovsky, L. R., and Castilla, V. Dehydroepiandrosterone, epiandrosterone and synthetic derivatives inhibit Junin virus replication in vitro. Virus Res 2008;135(2):203-212. View abstract.
Ahboucha, S., Pomier-Layrargues, G., Vincent, C., Hassoun, Z., Tamaz, R., Baker, G., and Butterworth, R. F. Reduced plasma dehydroepiandrosterone sulfate levels are significantly correlated with fatigue severity in patients with primary biliary cirrhosis. Neurochem.Int. 2008;52(4-5):569-574. View abstract.
Aldred, S. and Mecocci, P. Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients. Arch.Gerontol.Geriatr. 2010;51(1):e16-e18. View abstract.
Alexaki, V. I., Charalampopoulos, I., Panayotopoulou, M., Kampa, M., Gravanis, A., and Castanas, E. Dehydroepiandrosterone protects human keratinocytes against apoptosis through membrane binding sites. Exp.Cell Res 8-1-2009;315(13):2275-2283. View abstract.
Anonymous. Clinical development plan: dehydroepiandrosterone (DHEA). J Cell Biochem.Suppl 1996;26S:86-99. View abstract.
Araneo, B. A., Shelby, J., Li, G. Z., Ku, W., and Daynes, R. A. Administration of dehydroepiandrosterone to burned mice preserves normal immunologic competence. Arch.Surg. 1993;128(3):318-325. View abstract.
Araneo, B. A., Woods, M. L., and Daynes, R. A. Reversal of the immunosenescent phenotype by dehydroepiandrosterone: hormone treatment provides an adjuvant effect on the immunization of aged mice with recombinant hepatitis B surface antigen. J Infect.Dis 1993;167(4):830-840. View abstract.
Armanini, D., Vecchio, F., Basso, A., Milone, F. F., Simoncini, M., Fiore, C., Mattarello, M. J., Sartorato, P., and Karbowiak, I. Alzheimer's disease: pathophysiological implications of measurement of plasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors. Endocrine. 2003;22(2):113-118. View abstract.
Azuma, T., Nagai, Y., Saito, T., Funauchi, M., Matsubara, T., and Sakoda, S. The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia. J Neurol.Sci. 1-1-1999;162(1):69-73. View abstract.
Barad, D., Brill, H., and Gleicher, N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Assist.Reprod.Genet. 2007;24(12):629-634. View abstract.
Barbetta, L., Dall'Asta, C., Re, T., Colombo, P., Travaglini, P., and Ambrosi, B. Androgen secretion in ectopic ACTH syndrome and in Cushing's disease: modifications before and after surgery. Horm.Metab Res 2001;33(10):596-601. View abstract.
Barrett-Connor, E., Kritz-Silverstein, D., and Edelstein, S. L. A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women. Am J Epidemiol. 1-15-1993;137(2):201-206. View abstract.
Baulieu, E. E. Dehydroepiandrosterone (DHEA): a fountain of youth? [editorial]. J Clin.Endocrinol.Metab 1996;81(9):3147-3151. View abstract.
Bednarek-Tupikowska, G., Tworowska-Bardzinska, U., Tupikowski, K., Bohdanowicz-Pawlak, A., Szymczak, J., Kubicka, E., Skoczynska, A., and Milewicz, A. The correlations between endogenous dehydroepiandrosterone sulfate and some atherosclerosis risk factors in premenopausal women. Med Sci Monit. 2008;14(1):CR37-CR41. View abstract.
Belisle, S., Schiff, I., and Tulchinsky, D. The use of constant infusion of unlabeled dehydroepiandrosterone for the assessment of its metabolic clearance rate, its half-life, and its conversion into estrogens. J Clin Endocrinol Metab 1980;50(1):117-121. View abstract.
Bernardi, F., Lanzone, A., Cento, R. M., Spada, R. S., Pezzani, I., Genazzani, A. D., Luisi, S., Luisi, M., Petraglia, F., and Genazzani, A. R. Allopregnanolone and dehydroepiandrosterone response to corticotropin- releasing factor in patients suffering from Alzheimer's disease and vascular dementia. Eur J Endocrinol 2000;142(5):466-471. View abstract.
Bhattoa, H. P., Kiss, E., Bettembuk, P., and Balogh, A. Bone mineral density, biochemical markers of bone turnover, and hormonal status in men with systemic lupus erythematosus. Rheumatol.Int 2001;21(3):97-102. View abstract.
Bobyleva, V., Bellei, M., Kneer, N., and Lardy, H. The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Arch.Biochem Biophys. 5-1-1997;341(1):122-128. View abstract.
Bonnet, S., Paulin, R., Sutendra, G., Dromparis, P., Roy, M., Watson, K. O., Nagendran, J., Haromy, A., Dyck, J. R., and Michelakis, E. D. Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis. Circulation 9-29-2009;120(13):1231-1240. View abstract.
Bosdou, J. K., Venetis, C. A., Kolibianakis, E. M., Toulis, K. A., Goulis, D. G., Zepiridis, L., and Tarlatzis, B. C. The use of androgens or androgen-modulating agents in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Hum Reprod.Update. 2012;18(2):127-145. View abstract.
Bowers, L. D. Oral dehydroepiandrosterone supplementation can increase the testosterone/epitestosterone ratio. Clin.Chem. 1999;45(2):295-297. View abstract.
Bradley, M., McElhiney, M., and Rabkin, J. DHEA and cognition in HIV-positive patients with non-major depression. Psychosomatics 2012;53(3):244-249. View abstract.
Bremner, D., Vermetten, E., and Kelley, M. E. Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder. J Nerv.Ment.Dis 2007;195(11):919-927. View abstract.
Brooke, A. M., Kalingag, L. A., Miraki-Moud, F., Camacho-Hubner, C., Maher, K. T., Walker, D. M., Hinson, J. P., and Monson, J. P. Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement. J Clin Endocrinol.Metab 2006;91(10):3773-3779. View abstract.
Select a condition to view a list of vitamins
You Might Also Like
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.