Overview
In some parts of the body, black cohosh might increase the effects of estrogen. In other parts of the body, black cohosh might decrease the effects of estrogen. Black cohosh should not be thought of as an "herbal estrogen" or a substitute for estrogen.
People commonly use black cohosh for symptoms of menopause, premenstrual syndrome (PMS), painful menstruation, weak and brittle bones, and many other conditions, there is no good scientific evidence to support most of these uses.
Don't confuse black cohosh with blue cohosh or white cohosh. These are unrelated plants.
Uses & Effectiveness ?
Possibly Effective for
- Symptoms of menopause. Taking a specific black cohosh product (Remifemin, Phytopharmica/Enzymatic Therapy) seems to help reduce symptoms of menopause, such as hot flashes. But these benefits might not occur with all products that contain black cohosh.
Side Effects
Special Precautions and Warnings
Breast cancer: Black cohosh may worsen existing breast cancer. People who have breast cancer or who have had breast cancer in the past, and those at high-risk for breast cancer, should avoid black cohosh.
Hormone-sensitive conditions, including endometriosis, fibroids, ovarian cancer, uterine cancer, and others: Black cohosh acts somewhat like estrogen in the body. It might worsen conditions that are sensitive to estrogen. Don't take black cohosh if you have a condition that could be affected by female hormones.
Liver disease: Black cohosh might cause liver damage in some people. But it isn't clear how often this occurs. Until more is known, people with liver disease should avoid taking black cohosh.
Interactions ?
Cisplatin (Platinol-AQ) interacts with BLACK COHOSH
Cisplatin is used to treat cancer. There is some concern that black cohosh might decrease how well cisplatin works for cancer.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with BLACK COHOSH
Some medications are changed and broken down by the liver. Black cohosh might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that can harm the liver (Hepatotoxic drugs) interacts with BLACK COHOSH
Black cohosh might harm the liver. Some medications can also harm the liver. Taking black cohosh along with a medication that can harm the liver might increase the risk of liver damage.
Atorvastatin (Lipitor) interacts with BLACK COHOSH
There is concern that black cohosh might harm the liver. Taking black cohosh with atorvastatin might increase the chance of liver damage.
Moderate Interaction
Be cautious with this combination
Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates) interacts with BLACK COHOSH
Some medications are moved in and out of cells by pumps. Black cohosh might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Minor Interaction
Be watchful with this combination
Dosing
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