Sen. Roy Blunt (R-Mo.) will not run for re-election in 2022, he announced on Twitter Monday.

Why it matters: The 71-year-old senator is the No. 4-ranking Republican in the Senate. He was first elected to the Senate in 2010, after serving in the House for 14 years.

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Mayor Bill de Blasio announced on Monday that New York City's 488 public high schools will reopen for some in-person classes on March 22, after months of distance learning.

Why it matters: It's a key pandemic milestone for the biggest public school system in the country, which is made up largely of low-income and minority students, according to the New York Times.

The imminent enactment of Democrats' $1.9 trillion COVID-19 relief package creates space for lawmakers and the White House to craft infrastructure plans with big climate and energy-related provisions.

Why it matters: President Biden, during the campaign, vowed to make low-carbon energy, climate-resilient infrastructure and transportation projects a big focus of an economic recovery package. And the Texas power crisis could give fresh momentum to investments in grid modernization.

Sen. Joe Manchin (D-W.Va.), America's ultimate swing voter, told me on "Axios on HBO" that he'll insist Republicans have more of a voice on President Biden's next big package than they did on the COVID stimulus.

The big picture: Manchin said he'll push for tax hikes to pay for Biden's upcoming infrastructure and climate proposal, and will use his Energy Committee chairmanship to force the GOP to confront climate reality.

Florida Gov. Ron DeSantis said "the state was not involved" in helping to vaccinate 1,200 residents of the super-rich Ocean Reef community in January.

• But both the hospital system that supplied the doses and Monroe County have contradicted his claims, saying the state authorized the vaccines, the Tampa Bay Times and Miami Herald report.

Why it matters: DeSantis has faced increasing criticism for directing vaccines toward wealthy communities.

The tough task of selecting a jury for former MPD officer Derek Chauvin's trial for the killing of George Floyd is set to begin Monday.

The state of play: "This case may be the most highly publicized criminal trial in a long time. ... That means that it's harder to find people who really have an open mind," Richard Frase, University of Minnesota Law School professor of criminal law, told Axios.

Former Minneapolis police officer Derek Chauvin's trial for the murder of George Floyd stands out because it's so rare for officers to face any charges for deadly force — even for actions caught on video. But advocates hope times are changing.

Why it matters: Nearly a year after a video of Floyd's choking death went viral, advocates have pushed through proposals in states and cities to make it easier to hold police officers accountable for excessive force. The plans still face resistance from police unions.

Derek Chauvin, the Minneapolis police officer who was shown kneeling on George Floyd's neck last year in a video that shook the nation, goes on trial this week.

Why it matters: Eight years after the launch of the Black Lives Matter movement, it's still rare for police officers to face legal consequences or jail time over the deaths of Black people. Chauvin's trial will test how that precedent holds up.

President Biden will sign executive orders Monday establishing a Gender Policy Council and directing the Department of Education to review the federal law Title IX, according to administration officials.

Why it matters: The Biden administration is signaling its priorities to advance gender equity and equality as women, particularly women of color, have been disproportionately affected by the COVID-19 pandemic.

Secretary of State Antony Blinken said in a letter outlining a plan to accelerate peace talks with the Taliban that the U.S. is "considering" a full troop withdrawal from Afghanistan, Afghan outlet TOLOnews first reported Sunday.

Why it matters: In the letter to Afghan President Ashraf Ghani, also obtained by Western news outlets, Blinken expresses concern that the Taliban "could make rapid territorial gain" after an American military withdrawal, even with the continuation of U.S. financial aid, as he urges him to embrace his proposal.

Prince Harry and Meghan Markle delivered a devastating indictment of the U.K. royal family in their conversation with Oprah Winfrey: Both said unnamed relatives had expressed concern about what the skin tone of their baby would be. And they accused "the firm" of character assassination and "perpetuating falsehoods."

Why it matters: An institution that thrives on myth now faces harsh reality. The explosive two-hour interview gave an unprecedented, unsparing window into the monarchy: Harry said his father and brother "are trapped," and Markle revealed that the the misery of being a working royal drove her to thoughts of suicide.

The U.S. and South Korea announced Sunday they've reached an agreement "in principle" on a new cost-sharing plan for the American troop presence on the Korean Peninsula.

Driving the news: The State Department's Bureau of Political-Military Affairs said in a Twitter post there had been a "negotiated increase" from South Korea in support for the U.S. troops' presence, without elaborating further.

Thousands of protesters marched through Minneapolis' streets Sunday, urging justice for George Floyd on the eve of the start of former police officer Derek Chauvin's trial over the 46-year-old's death, per AFP.

The big picture: Chauvin faces charges for second-degree murder and manslaughter over Floyd's death last May, which ignited massive nationwide and global protests against racism and for police reform. His trial is due to start Monday, with jury selection procedures.